Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells

Abstract We have previously described a form of hepatocellular carcinoma (HCC) in non-cirrhotic liver (HCC-NC) developed by Peruvian patients. We analyzed the metallomic profile in hepatic tissues from two independent cohorts exhibiting HCC-NC. Clinical, histopathological data, and HCC and non-tumor...

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Autores principales:	Luis Cano, Stéphane Bertani, Marie-Laure Island, Juan Pablo Cerapio, Eloy Ruiz, Pascal Pineau, Valérie Monbet, Karim Boudjema, Luis Taxa, Sandro Casavilca-Zambrano, Martine Ropert, Bruno Turlin, Olivier Loréal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d9ef09b15fd43fc8be645d33730bfd9
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spelling	oai:doaj.org-article:7d9ef09b15fd43fc8be645d33730bfd92021-12-02T15:23:08ZMetallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells10.1038/s41598-021-93369-42045-2322https://doaj.org/article/7d9ef09b15fd43fc8be645d33730bfd92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93369-4https://doaj.org/toc/2045-2322Abstract We have previously described a form of hepatocellular carcinoma (HCC) in non-cirrhotic liver (HCC-NC) developed by Peruvian patients. We analyzed the metallomic profile in hepatic tissues from two independent cohorts exhibiting HCC-NC. Clinical, histopathological data, and HCC and non-tumoral liver (NTL) samples of 38 Peruvian and 38 French HCC-NC patients, were studied. Twelve metals were quantified using ICP/MS: Mn, Fe, Cu, Co, Zn, As, Se, Rb, Mo, Cd, Pb, and Sn. Associations between metals and survival were assessed. Our data showed significant differences between cohorts. Mean ages were 40.6 ± 20, 67.5 ± 9 years old for Peruvians and French, respectively. Fifty percent of the Peruvian patients were positive for the HBsAg, versus 3% in French patients. Mn, Cu, Zn, As, Se, Rb, Mo, Cd, Sn metal concentrations were higher in NTL of Peruvians. Importantly, metal concentrations were lower in HCC areas compared to NTL tissues in both cohorts, except for Cu for which mean concentration was higher in HCC (p < 0.05). Se concentration in HCC was associated with extended survival only in Peruvians. Our data, obtained in Peruvian and French HCC-NC cohorts, highlights similarity in the metallomic profile of HCC compared to NTL during the hepatic tumorigenesis in these specific groups of patients.Luis CanoStéphane BertaniMarie-Laure IslandJuan Pablo CerapioEloy RuizPascal PineauValérie MonbetKarim BoudjemaLuis TaxaSandro Casavilca-ZambranoMartine RopertBruno TurlinOlivier LoréalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luis Cano Stéphane Bertani Marie-Laure Island Juan Pablo Cerapio Eloy Ruiz Pascal Pineau Valérie Monbet Karim Boudjema Luis Taxa Sandro Casavilca-Zambrano Martine Ropert Bruno Turlin Olivier Loréal Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells
description	Abstract We have previously described a form of hepatocellular carcinoma (HCC) in non-cirrhotic liver (HCC-NC) developed by Peruvian patients. We analyzed the metallomic profile in hepatic tissues from two independent cohorts exhibiting HCC-NC. Clinical, histopathological data, and HCC and non-tumoral liver (NTL) samples of 38 Peruvian and 38 French HCC-NC patients, were studied. Twelve metals were quantified using ICP/MS: Mn, Fe, Cu, Co, Zn, As, Se, Rb, Mo, Cd, Pb, and Sn. Associations between metals and survival were assessed. Our data showed significant differences between cohorts. Mean ages were 40.6 ± 20, 67.5 ± 9 years old for Peruvians and French, respectively. Fifty percent of the Peruvian patients were positive for the HBsAg, versus 3% in French patients. Mn, Cu, Zn, As, Se, Rb, Mo, Cd, Sn metal concentrations were higher in NTL of Peruvians. Importantly, metal concentrations were lower in HCC areas compared to NTL tissues in both cohorts, except for Cu for which mean concentration was higher in HCC (p < 0.05). Se concentration in HCC was associated with extended survival only in Peruvians. Our data, obtained in Peruvian and French HCC-NC cohorts, highlights similarity in the metallomic profile of HCC compared to NTL during the hepatic tumorigenesis in these specific groups of patients.
format	article
author	Luis Cano Stéphane Bertani Marie-Laure Island Juan Pablo Cerapio Eloy Ruiz Pascal Pineau Valérie Monbet Karim Boudjema Luis Taxa Sandro Casavilca-Zambrano Martine Ropert Bruno Turlin Olivier Loréal
author_facet	Luis Cano Stéphane Bertani Marie-Laure Island Juan Pablo Cerapio Eloy Ruiz Pascal Pineau Valérie Monbet Karim Boudjema Luis Taxa Sandro Casavilca-Zambrano Martine Ropert Bruno Turlin Olivier Loréal
author_sort	Luis Cano
title	Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells
title_short	Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells
title_full	Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells
title_fullStr	Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells
title_full_unstemmed	Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells
title_sort	metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d9ef09b15fd43fc8be645d33730bfd9
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Metallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells

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