Rare Metastasis to the Submandibular Gland in Oral Squamous Cell Carcinoma
PurposeIn the current recommendation of neck dissection in oral squamous cell carcinoma (OSCC), the submandibular gland (SMG) should also be removed. This study aimed to investigate the incidence and the patterns of SMG involvement in OSCC patients.MethodsPatients initially diagnosed with OSCC betwe...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:7da312c306d7460ea5a5ebaf131bdaf02021-12-01T04:14:28ZRare Metastasis to the Submandibular Gland in Oral Squamous Cell Carcinoma2234-943X10.3389/fonc.2021.728230https://doaj.org/article/7da312c306d7460ea5a5ebaf131bdaf02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.728230/fullhttps://doaj.org/toc/2234-943XPurposeIn the current recommendation of neck dissection in oral squamous cell carcinoma (OSCC), the submandibular gland (SMG) should also be removed. This study aimed to investigate the incidence and the patterns of SMG involvement in OSCC patients.MethodsPatients initially diagnosed with OSCC between January 2018 and October 2020 were included. The distribution of lymph nodes metastasis in level IB was analyzed.ResultsWe included 145 patients who underwent primary surgery and neck dissection in this study. All patients had level IB lymph node dissection and simultaneous removal of the SMG. Of these patients, only one patient (0.7%) had involvement in SMG by directly infiltrating from the primary tumor. A total of 18 positive lymph nodes were found in level IB in 16 patients, and no positive lymph nodes were located in the SMG. There were 6 lymph nodes located in the lateral part of the SMG and 12 lymph nodes located in the anterior of the SMG. Patients with tumors located in the buccal mucosa and N3 stage were the independent predictive factors associated with level IB nodal metastasis.ConclusionInvolvement of SMG in OSCC is quite rare. Preservation of the SMG during neck dissection in selected patients with OSCC seems to be feasible and oncologically safe.Ping ZhouJing-Xin ChenYuan ZhouChen-Lu LianBing YanSan-Gang WuFrontiers Media S.A.articleoral squamous cell carcinomasubmandibular glandorgan preservationlevel IB metastasishead and neck cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
oral squamous cell carcinoma submandibular gland organ preservation level IB metastasis head and neck cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
oral squamous cell carcinoma submandibular gland organ preservation level IB metastasis head and neck cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ping Zhou Jing-Xin Chen Yuan Zhou Chen-Lu Lian Bing Yan San-Gang Wu Rare Metastasis to the Submandibular Gland in Oral Squamous Cell Carcinoma |
| description |
PurposeIn the current recommendation of neck dissection in oral squamous cell carcinoma (OSCC), the submandibular gland (SMG) should also be removed. This study aimed to investigate the incidence and the patterns of SMG involvement in OSCC patients.MethodsPatients initially diagnosed with OSCC between January 2018 and October 2020 were included. The distribution of lymph nodes metastasis in level IB was analyzed.ResultsWe included 145 patients who underwent primary surgery and neck dissection in this study. All patients had level IB lymph node dissection and simultaneous removal of the SMG. Of these patients, only one patient (0.7%) had involvement in SMG by directly infiltrating from the primary tumor. A total of 18 positive lymph nodes were found in level IB in 16 patients, and no positive lymph nodes were located in the SMG. There were 6 lymph nodes located in the lateral part of the SMG and 12 lymph nodes located in the anterior of the SMG. Patients with tumors located in the buccal mucosa and N3 stage were the independent predictive factors associated with level IB nodal metastasis.ConclusionInvolvement of SMG in OSCC is quite rare. Preservation of the SMG during neck dissection in selected patients with OSCC seems to be feasible and oncologically safe. |
| format |
article |
| author |
Ping Zhou Jing-Xin Chen Yuan Zhou Chen-Lu Lian Bing Yan San-Gang Wu |
| author_facet |
Ping Zhou Jing-Xin Chen Yuan Zhou Chen-Lu Lian Bing Yan San-Gang Wu |
| author_sort |
Ping Zhou |
| title |
Rare Metastasis to the Submandibular Gland in Oral Squamous Cell Carcinoma |
| title_short |
Rare Metastasis to the Submandibular Gland in Oral Squamous Cell Carcinoma |
| title_full |
Rare Metastasis to the Submandibular Gland in Oral Squamous Cell Carcinoma |
| title_fullStr |
Rare Metastasis to the Submandibular Gland in Oral Squamous Cell Carcinoma |
| title_full_unstemmed |
Rare Metastasis to the Submandibular Gland in Oral Squamous Cell Carcinoma |
| title_sort |
rare metastasis to the submandibular gland in oral squamous cell carcinoma |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/7da312c306d7460ea5a5ebaf131bdaf0 |
| work_keys_str_mv |
AT pingzhou raremetastasistothesubmandibularglandinoralsquamouscellcarcinoma AT jingxinchen raremetastasistothesubmandibularglandinoralsquamouscellcarcinoma AT yuanzhou raremetastasistothesubmandibularglandinoralsquamouscellcarcinoma AT chenlulian raremetastasistothesubmandibularglandinoralsquamouscellcarcinoma AT bingyan raremetastasistothesubmandibularglandinoralsquamouscellcarcinoma AT sangangwu raremetastasistothesubmandibularglandinoralsquamouscellcarcinoma |
| _version_ |
1718405912221188096 |