Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis

Colorectal cancer (CRC) is the third most common malignancy worldwide. Circular RNAs (circRNAs) have been implicated in cancer biology. The purpose of the current work is to investigate the precise parts of circRNA centrosome and spindle pole-associated protein 1 (circ-CSPP1) in the progression of C...

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Autores principales:	Li Minghao, Zhuang Jianbin, Kang Di, Chen Yuzhuo, Song Weiliang
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	colorectal cancer circ-cspp1 mir-431 lasp1 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7da4b42183e74ed68fc8d63462ccce80
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spelling	oai:doaj.org-article:7da4b42183e74ed68fc8d63462ccce802021-12-05T14:10:41ZIdentification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis2391-541210.1515/biol-2021-0053https://doaj.org/article/7da4b42183e74ed68fc8d63462ccce802021-05-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0053https://doaj.org/toc/2391-5412Colorectal cancer (CRC) is the third most common malignancy worldwide. Circular RNAs (circRNAs) have been implicated in cancer biology. The purpose of the current work is to investigate the precise parts of circRNA centrosome and spindle pole-associated protein 1 (circ-CSPP1) in the progression of CRC. Our data showed that circ-CSPP1 was significantly overexpressed in CRC tissues and cells. The knockdown of circ-CSPP1 attenuated cell proliferation, migration, invasion and promoted apoptosis in vitro and weakened tumor growth in vivo. circ-CSPP1 directly targeted miR-431, and circ-CSPP1 knockdown modulated CRC cell progression in vitro via upregulating miR-431. Moreover, LIM and SH3 protein 1 (LASP1) was a functional target of miR-431 in modulating CRC cell malignant progression. Furthermore, circ-CSPP1 in CRC cells functioned as a posttranscriptional regulator on LASP1 expression by targeting miR-431. Our present study identified the oncogenic role of circ-CSPP1 in CRC partially by the modulation of the miR-431/LASP1 axis, providing evidence for circ-CSPP1 as a promising biomarker for CRC management.Li MinghaoZhuang JianbinKang DiChen YuzhuoSong WeiliangDe Gruyterarticlecolorectal cancercirc-cspp1mir-431lasp1Biology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 523-536 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer circ-cspp1 mir-431 lasp1 Biology (General) QH301-705.5
spellingShingle	colorectal cancer circ-cspp1 mir-431 lasp1 Biology (General) QH301-705.5 Li Minghao Zhuang Jianbin Kang Di Chen Yuzhuo Song Weiliang Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis
description	Colorectal cancer (CRC) is the third most common malignancy worldwide. Circular RNAs (circRNAs) have been implicated in cancer biology. The purpose of the current work is to investigate the precise parts of circRNA centrosome and spindle pole-associated protein 1 (circ-CSPP1) in the progression of CRC. Our data showed that circ-CSPP1 was significantly overexpressed in CRC tissues and cells. The knockdown of circ-CSPP1 attenuated cell proliferation, migration, invasion and promoted apoptosis in vitro and weakened tumor growth in vivo. circ-CSPP1 directly targeted miR-431, and circ-CSPP1 knockdown modulated CRC cell progression in vitro via upregulating miR-431. Moreover, LIM and SH3 protein 1 (LASP1) was a functional target of miR-431 in modulating CRC cell malignant progression. Furthermore, circ-CSPP1 in CRC cells functioned as a posttranscriptional regulator on LASP1 expression by targeting miR-431. Our present study identified the oncogenic role of circ-CSPP1 in CRC partially by the modulation of the miR-431/LASP1 axis, providing evidence for circ-CSPP1 as a promising biomarker for CRC management.
format	article
author	Li Minghao Zhuang Jianbin Kang Di Chen Yuzhuo Song Weiliang
author_facet	Li Minghao Zhuang Jianbin Kang Di Chen Yuzhuo Song Weiliang
author_sort	Li Minghao
title	Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis
title_short	Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis
title_full	Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis
title_fullStr	Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis
title_full_unstemmed	Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis
title_sort	identification of circrna circ-cspp1 as a potent driver of colorectal cancer by directly targeting the mir-431/lasp1 axis
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/7da4b42183e74ed68fc8d63462ccce80
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Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis

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