Voice-selective prediction alterations in nonclinical voice hearers

Abstract Auditory verbal hallucinations (AVH) are a cardinal symptom of psychosis but also occur in 6–13% of the general population. Voice perception is thought to engage an internal forward model that generates predictions, preparing the auditory cortex for upcoming sensory feedback. Impaired proce...

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Autores principales:	Ana P. Pinheiro, Michael Schwartze, Sonja A. Kotz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Auditory Verbal Hallucinations (AVH) Internal Forward Model Psychosis Continuum Altered Sensory Feedback Alpha Power Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7da7648f424d494d88f360cff9bd098a
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spelling	oai:doaj.org-article:7da7648f424d494d88f360cff9bd098a2021-12-02T11:40:54ZVoice-selective prediction alterations in nonclinical voice hearers10.1038/s41598-018-32614-92045-2322https://doaj.org/article/7da7648f424d494d88f360cff9bd098a2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32614-9https://doaj.org/toc/2045-2322Abstract Auditory verbal hallucinations (AVH) are a cardinal symptom of psychosis but also occur in 6–13% of the general population. Voice perception is thought to engage an internal forward model that generates predictions, preparing the auditory cortex for upcoming sensory feedback. Impaired processing of sensory feedback in vocalization seems to underlie the experience of AVH in psychosis, but whether this is the case in nonclinical voice hearers remains unclear. The current study used electroencephalography (EEG) to investigate whether and how hallucination predisposition (HP) modulates the internal forward model in response to self-initiated tones and self-voices. Participants varying in HP (based on the Launay-Slade Hallucination Scale) listened to self-generated and externally generated tones or self-voices. HP did not affect responses to self vs. externally generated tones. However, HP altered the processing of the self-generated voice: increased HP was associated with increased pre-stimulus alpha power and increased N1 response to the self-generated voice. HP did not affect the P2 response to voices. These findings confirm that both prediction and comparison of predicted and perceived feedback to a self-generated voice are altered in individuals with AVH predisposition. Specific alterations in the processing of self-generated vocalizations may establish a core feature of the psychosis continuum.Ana P. PinheiroMichael SchwartzeSonja A. KotzNature PortfolioarticleAuditory Verbal Hallucinations (AVH)Internal Forward ModelPsychosis ContinuumAltered Sensory FeedbackAlpha PowerMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Auditory Verbal Hallucinations (AVH) Internal Forward Model Psychosis Continuum Altered Sensory Feedback Alpha Power Medicine R Science Q
spellingShingle	Auditory Verbal Hallucinations (AVH) Internal Forward Model Psychosis Continuum Altered Sensory Feedback Alpha Power Medicine R Science Q Ana P. Pinheiro Michael Schwartze Sonja A. Kotz Voice-selective prediction alterations in nonclinical voice hearers
description	Abstract Auditory verbal hallucinations (AVH) are a cardinal symptom of psychosis but also occur in 6–13% of the general population. Voice perception is thought to engage an internal forward model that generates predictions, preparing the auditory cortex for upcoming sensory feedback. Impaired processing of sensory feedback in vocalization seems to underlie the experience of AVH in psychosis, but whether this is the case in nonclinical voice hearers remains unclear. The current study used electroencephalography (EEG) to investigate whether and how hallucination predisposition (HP) modulates the internal forward model in response to self-initiated tones and self-voices. Participants varying in HP (based on the Launay-Slade Hallucination Scale) listened to self-generated and externally generated tones or self-voices. HP did not affect responses to self vs. externally generated tones. However, HP altered the processing of the self-generated voice: increased HP was associated with increased pre-stimulus alpha power and increased N1 response to the self-generated voice. HP did not affect the P2 response to voices. These findings confirm that both prediction and comparison of predicted and perceived feedback to a self-generated voice are altered in individuals with AVH predisposition. Specific alterations in the processing of self-generated vocalizations may establish a core feature of the psychosis continuum.
format	article
author	Ana P. Pinheiro Michael Schwartze Sonja A. Kotz
author_facet	Ana P. Pinheiro Michael Schwartze Sonja A. Kotz
author_sort	Ana P. Pinheiro
title	Voice-selective prediction alterations in nonclinical voice hearers
title_short	Voice-selective prediction alterations in nonclinical voice hearers
title_full	Voice-selective prediction alterations in nonclinical voice hearers
title_fullStr	Voice-selective prediction alterations in nonclinical voice hearers
title_full_unstemmed	Voice-selective prediction alterations in nonclinical voice hearers
title_sort	voice-selective prediction alterations in nonclinical voice hearers
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7da7648f424d494d88f360cff9bd098a
work_keys_str_mv	AT anappinheiro voiceselectivepredictionalterationsinnonclinicalvoicehearers AT michaelschwartze voiceselectivepredictionalterationsinnonclinicalvoicehearers AT sonjaakotz voiceselectivepredictionalterationsinnonclinicalvoicehearers
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Voice-selective prediction alterations in nonclinical voice hearers

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