Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor

Identification of inhibitors can be accelerated by using the target as a template for ligand formation. Here the authors show that DNA-functionalised magnetic nanoparticles guide templating of G-quadruplex bindingc-MYCinhibitors from an array of building blocks, and can be isolated by magnetic decan...

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Autores principales:	Deepanjan Panda, Puja Saha, Tania Das, Jyotirmayee Dash
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7da98346636d440491fe4fd673780c1d
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spelling	oai:doaj.org-article:7da98346636d440491fe4fd673780c1d2021-12-02T14:42:07ZTarget guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor10.1038/ncomms161032041-1723https://doaj.org/article/7da98346636d440491fe4fd673780c1d2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16103https://doaj.org/toc/2041-1723Identification of inhibitors can be accelerated by using the target as a template for ligand formation. Here the authors show that DNA-functionalised magnetic nanoparticles guide templating of G-quadruplex bindingc-MYCinhibitors from an array of building blocks, and can be isolated by magnetic decanting.Deepanjan PandaPuja SahaTania DasJyotirmayee DashNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deepanjan Panda Puja Saha Tania Das Jyotirmayee Dash Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor
description	Identification of inhibitors can be accelerated by using the target as a template for ligand formation. Here the authors show that DNA-functionalised magnetic nanoparticles guide templating of G-quadruplex bindingc-MYCinhibitors from an array of building blocks, and can be isolated by magnetic decanting.
format	article
author	Deepanjan Panda Puja Saha Tania Das Jyotirmayee Dash
author_facet	Deepanjan Panda Puja Saha Tania Das Jyotirmayee Dash
author_sort	Deepanjan Panda
title	Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor
title_short	Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor
title_full	Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor
title_fullStr	Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor
title_full_unstemmed	Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor
title_sort	target guided synthesis using dna nano-templates for selectively assembling a g-quadruplex binding c-myc inhibitor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7da98346636d440491fe4fd673780c1d
work_keys_str_mv	AT deepanjanpanda targetguidedsynthesisusingdnananotemplatesforselectivelyassemblingagquadruplexbindingcmycinhibitor AT pujasaha targetguidedsynthesisusingdnananotemplatesforselectivelyassemblingagquadruplexbindingcmycinhibitor AT taniadas targetguidedsynthesisusingdnananotemplatesforselectivelyassemblingagquadruplexbindingcmycinhibitor AT jyotirmayeedash targetguidedsynthesisusingdnananotemplatesforselectivelyassemblingagquadruplexbindingcmycinhibitor
_version_	1718389817925959680

Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor

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