Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium

HSCs emerge from haemogenic endothelium (HE) in the dorsal aorta but whether these tissues share a common lineage is unclear. Here, the authors use a zebrafish runx1 reporter to show that HE maintains an arterial gene expression profile in the absence of Runx1, suggesting the aortic endothelium as a...

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Autores principales:	Florian Bonkhofer, Rossella Rispoli, Philip Pinheiro, Monika Krecsmarik, Janina Schneider-Swales, Ingrid Ho Ching Tsang, Marella de Bruijn, Rui Monteiro, Tessa Peterkin, Roger Patient
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7daa7a5352524efcafc9c49f85909b86
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spelling	oai:doaj.org-article:7daa7a5352524efcafc9c49f85909b862021-12-02T14:38:37ZBlood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium10.1038/s41467-019-11423-22041-1723https://doaj.org/article/7daa7a5352524efcafc9c49f85909b862019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11423-2https://doaj.org/toc/2041-1723HSCs emerge from haemogenic endothelium (HE) in the dorsal aorta but whether these tissues share a common lineage is unclear. Here, the authors use a zebrafish runx1 reporter to show that HE maintains an arterial gene expression profile in the absence of Runx1, suggesting the aortic endothelium as a precursor of HE.Florian BonkhoferRossella RispoliPhilip PinheiroMonika KrecsmarikJanina Schneider-SwalesIngrid Ho Ching TsangMarella de BruijnRui MonteiroTessa PeterkinRoger PatientNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florian Bonkhofer Rossella Rispoli Philip Pinheiro Monika Krecsmarik Janina Schneider-Swales Ingrid Ho Ching Tsang Marella de Bruijn Rui Monteiro Tessa Peterkin Roger Patient Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium
description	HSCs emerge from haemogenic endothelium (HE) in the dorsal aorta but whether these tissues share a common lineage is unclear. Here, the authors use a zebrafish runx1 reporter to show that HE maintains an arterial gene expression profile in the absence of Runx1, suggesting the aortic endothelium as a precursor of HE.
format	article
author	Florian Bonkhofer Rossella Rispoli Philip Pinheiro Monika Krecsmarik Janina Schneider-Swales Ingrid Ho Ching Tsang Marella de Bruijn Rui Monteiro Tessa Peterkin Roger Patient
author_facet	Florian Bonkhofer Rossella Rispoli Philip Pinheiro Monika Krecsmarik Janina Schneider-Swales Ingrid Ho Ching Tsang Marella de Bruijn Rui Monteiro Tessa Peterkin Roger Patient
author_sort	Florian Bonkhofer
title	Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium
title_short	Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium
title_full	Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium
title_fullStr	Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium
title_full_unstemmed	Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium
title_sort	blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7daa7a5352524efcafc9c49f85909b86
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Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium

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