Sugar phosphate activation of the stress sensor eIF2B

The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthe...

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Autores principales:	Qi Hao, Jin-Mi Heo, Boguslaw P. Nocek, Kevin G. Hicks, Vincent S. Stoll, Clint Remarcik, Sean Hackett, Lauren LeBon, Rinku Jain, Dan Eaton, Jared Rutter, Yao Liang Wong, Carmela Sidrauski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7dab3274bc6948168fa0acd7979be94e
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spelling	oai:doaj.org-article:7dab3274bc6948168fa0acd7979be94e2021-12-02T18:06:34ZSugar phosphate activation of the stress sensor eIF2B10.1038/s41467-021-23836-z2041-1723https://doaj.org/article/7dab3274bc6948168fa0acd7979be94e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23836-zhttps://doaj.org/toc/2041-1723The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthesis.Qi HaoJin-Mi HeoBoguslaw P. NocekKevin G. HicksVincent S. StollClint RemarcikSean HackettLauren LeBonRinku JainDan EatonJared RutterYao Liang WongCarmela SidrauskiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qi Hao Jin-Mi Heo Boguslaw P. Nocek Kevin G. Hicks Vincent S. Stoll Clint Remarcik Sean Hackett Lauren LeBon Rinku Jain Dan Eaton Jared Rutter Yao Liang Wong Carmela Sidrauski Sugar phosphate activation of the stress sensor eIF2B
description	The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthesis.
format	article
author	Qi Hao Jin-Mi Heo Boguslaw P. Nocek Kevin G. Hicks Vincent S. Stoll Clint Remarcik Sean Hackett Lauren LeBon Rinku Jain Dan Eaton Jared Rutter Yao Liang Wong Carmela Sidrauski
author_facet	Qi Hao Jin-Mi Heo Boguslaw P. Nocek Kevin G. Hicks Vincent S. Stoll Clint Remarcik Sean Hackett Lauren LeBon Rinku Jain Dan Eaton Jared Rutter Yao Liang Wong Carmela Sidrauski
author_sort	Qi Hao
title	Sugar phosphate activation of the stress sensor eIF2B
title_short	Sugar phosphate activation of the stress sensor eIF2B
title_full	Sugar phosphate activation of the stress sensor eIF2B
title_fullStr	Sugar phosphate activation of the stress sensor eIF2B
title_full_unstemmed	Sugar phosphate activation of the stress sensor eIF2B
title_sort	sugar phosphate activation of the stress sensor eif2b
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7dab3274bc6948168fa0acd7979be94e
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Sugar phosphate activation of the stress sensor eIF2B

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