Differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin

Abstract The domesticated silkworm Bombyx mori has an innate immune system, whose main effectors are the antimicrobial peptides (AMPs). Silkworm strains are commonly grouped into four geographical types (Japanese, Chinese, European and Tropical) and are generally characterised by a variable suscepti...

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Autores principales:	Ottavia Romoli, Alessio Saviane, Andrea Bozzato, Paola D’Antona, Gianluca Tettamanti, Andrea Squartini, Silvia Cappellozza, Federica Sandrelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7db01c6c71e14fc0bd1ac0bac5c9de57
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spelling	oai:doaj.org-article:7db01c6c71e14fc0bd1ac0bac5c9de572021-12-02T12:30:11ZDifferential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin10.1038/s41598-017-01162-z2045-2322https://doaj.org/article/7db01c6c71e14fc0bd1ac0bac5c9de572017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01162-zhttps://doaj.org/toc/2045-2322Abstract The domesticated silkworm Bombyx mori has an innate immune system, whose main effectors are the antimicrobial peptides (AMPs). Silkworm strains are commonly grouped into four geographical types (Japanese, Chinese, European and Tropical) and are generally characterised by a variable susceptibility to infections. To clarify the genetic and molecular mechanisms on which the different responses to infections are based, we exposed one silkworm strain for each geographical area to oral infections with the silkworm pathogens Enterococcus mundtii or Serratia marcescens. We detected a differential susceptibility to both bacteria, with the European strain displaying the lowest sensitivity to E. mundtii and the Indian one to S. marcescens. We found that all the strains were able to activate the AMP response against E. mundtii. However, the highest tolerance of the European strain appeared to be related to the specific composition of its AMP cocktail, containing more effective variants such as a peculiar Cecropin B6 isoform. The resistance of the Indian strain to S. marcescens seemed to be associated with its prompt capability to activate the systemic transcription of AMPs. These data suggest that B. mori strains with distinct genetic backgrounds employ different strategies to counteract bacterial infections, whose efficacy appears to be pathogen-dependent.Ottavia RomoliAlessio SavianeAndrea BozzatoPaola D’AntonaGianluca TettamantiAndrea SquartiniSilvia CappellozzaFederica SandrelliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ottavia Romoli Alessio Saviane Andrea Bozzato Paola D’Antona Gianluca Tettamanti Andrea Squartini Silvia Cappellozza Federica Sandrelli Differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin
description	Abstract The domesticated silkworm Bombyx mori has an innate immune system, whose main effectors are the antimicrobial peptides (AMPs). Silkworm strains are commonly grouped into four geographical types (Japanese, Chinese, European and Tropical) and are generally characterised by a variable susceptibility to infections. To clarify the genetic and molecular mechanisms on which the different responses to infections are based, we exposed one silkworm strain for each geographical area to oral infections with the silkworm pathogens Enterococcus mundtii or Serratia marcescens. We detected a differential susceptibility to both bacteria, with the European strain displaying the lowest sensitivity to E. mundtii and the Indian one to S. marcescens. We found that all the strains were able to activate the AMP response against E. mundtii. However, the highest tolerance of the European strain appeared to be related to the specific composition of its AMP cocktail, containing more effective variants such as a peculiar Cecropin B6 isoform. The resistance of the Indian strain to S. marcescens seemed to be associated with its prompt capability to activate the systemic transcription of AMPs. These data suggest that B. mori strains with distinct genetic backgrounds employ different strategies to counteract bacterial infections, whose efficacy appears to be pathogen-dependent.
format	article
author	Ottavia Romoli Alessio Saviane Andrea Bozzato Paola D’Antona Gianluca Tettamanti Andrea Squartini Silvia Cappellozza Federica Sandrelli
author_facet	Ottavia Romoli Alessio Saviane Andrea Bozzato Paola D’Antona Gianluca Tettamanti Andrea Squartini Silvia Cappellozza Federica Sandrelli
author_sort	Ottavia Romoli
title	Differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin
title_short	Differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin
title_full	Differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin
title_fullStr	Differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin
title_full_unstemmed	Differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin
title_sort	differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7db01c6c71e14fc0bd1ac0bac5c9de57
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Differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin

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