Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA

How gene expression reactivation is promoted following DNA damage is not yet clear. Here, the authors identify a role for the human histone chaperone complex HIRA in transcription restart following UV damage independently of its function in new H3.3 histone deposition.

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Autores principales:	Déborah Bouvier, Juliette Ferrand, Odile Chevallier, Michelle T. Paulsen, Mats Ljungman, Sophie E. Polo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7db3854249e44f02962f884bc325329e
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spelling	oai:doaj.org-article:7db3854249e44f02962f884bc325329e2021-12-02T17:12:20ZDissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA10.1038/s41467-021-24153-12041-1723https://doaj.org/article/7db3854249e44f02962f884bc325329e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24153-1https://doaj.org/toc/2041-1723How gene expression reactivation is promoted following DNA damage is not yet clear. Here, the authors identify a role for the human histone chaperone complex HIRA in transcription restart following UV damage independently of its function in new H3.3 histone deposition.Déborah BouvierJuliette FerrandOdile ChevallierMichelle T. PaulsenMats LjungmanSophie E. PoloNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Déborah Bouvier Juliette Ferrand Odile Chevallier Michelle T. Paulsen Mats Ljungman Sophie E. Polo Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA
description	How gene expression reactivation is promoted following DNA damage is not yet clear. Here, the authors identify a role for the human histone chaperone complex HIRA in transcription restart following UV damage independently of its function in new H3.3 histone deposition.
format	article
author	Déborah Bouvier Juliette Ferrand Odile Chevallier Michelle T. Paulsen Mats Ljungman Sophie E. Polo
author_facet	Déborah Bouvier Juliette Ferrand Odile Chevallier Michelle T. Paulsen Mats Ljungman Sophie E. Polo
author_sort	Déborah Bouvier
title	Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA
title_short	Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA
title_full	Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA
title_fullStr	Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA
title_full_unstemmed	Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA
title_sort	dissecting regulatory pathways for transcription recovery following dna damage reveals a non-canonical function of the histone chaperone hira
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7db3854249e44f02962f884bc325329e
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Dissecting regulatory pathways for transcription recovery following DNA damage reveals a non-canonical function of the histone chaperone HIRA

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