Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases

Mitochondria associated membranes (MAMs), as the name suggests, are the membranes that physically and biochemically connect mitochondria with endoplasmic reticulum. MAMs not only structurally but also functionally connect these two important organelles within the cell which were previously thought t...

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Autores principales:	Ashu Johri, Abhishek Chandra
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mitochondria associated membranes (MAMs) Alzheimer’s disease Huntington’s disease Parkinson’s disease amyotrophic lateral sclerosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/7db66870092b4c2a896c6c90d17a26e1
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spelling	oai:doaj.org-article:7db66870092b4c2a896c6c90d17a26e12021-11-25T16:57:22ZConnection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases10.3390/brainsci111114372076-3425https://doaj.org/article/7db66870092b4c2a896c6c90d17a26e12021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1437https://doaj.org/toc/2076-3425Mitochondria associated membranes (MAMs), as the name suggests, are the membranes that physically and biochemically connect mitochondria with endoplasmic reticulum. MAMs not only structurally but also functionally connect these two important organelles within the cell which were previously thought to exist independently. There are multiple points of communication between ER–mitochondria and MAMs play an important role in both ER and mitochondria functions such as Ca<sup>2+</sup> homeostasis, proteostasis, mitochondrial bioenergetics, movement, and mitophagy. The number of disease-related proteins and genes being associated with MAMs has been continually on the rise since its discovery. There is an overwhelming overlap between the biochemical functions of MAMs and processes affected in neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). Thus, MAMs have received well-deserving and much delayed attention as modulators for ER–mitochondria communication and function. This review briefly discusses the recent progress made in this now fast developing field full of promise for very exciting future therapeutic discoveries.Ashu JohriAbhishek ChandraMDPI AGarticlemitochondria associated membranes (MAMs)Alzheimer’s diseaseHuntington’s diseaseParkinson’s diseaseamyotrophic lateral sclerosisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1437, p 1437 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondria associated membranes (MAMs) Alzheimer’s disease Huntington’s disease Parkinson’s disease amyotrophic lateral sclerosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	mitochondria associated membranes (MAMs) Alzheimer’s disease Huntington’s disease Parkinson’s disease amyotrophic lateral sclerosis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Ashu Johri Abhishek Chandra Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
description	Mitochondria associated membranes (MAMs), as the name suggests, are the membranes that physically and biochemically connect mitochondria with endoplasmic reticulum. MAMs not only structurally but also functionally connect these two important organelles within the cell which were previously thought to exist independently. There are multiple points of communication between ER–mitochondria and MAMs play an important role in both ER and mitochondria functions such as Ca<sup>2+</sup> homeostasis, proteostasis, mitochondrial bioenergetics, movement, and mitophagy. The number of disease-related proteins and genes being associated with MAMs has been continually on the rise since its discovery. There is an overwhelming overlap between the biochemical functions of MAMs and processes affected in neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). Thus, MAMs have received well-deserving and much delayed attention as modulators for ER–mitochondria communication and function. This review briefly discusses the recent progress made in this now fast developing field full of promise for very exciting future therapeutic discoveries.
format	article
author	Ashu Johri Abhishek Chandra
author_facet	Ashu Johri Abhishek Chandra
author_sort	Ashu Johri
title	Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
title_short	Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
title_full	Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
title_fullStr	Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
title_full_unstemmed	Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases
title_sort	connection lost, mam: errors in er–mitochondria connections in neurodegenerative diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7db66870092b4c2a896c6c90d17a26e1
work_keys_str_mv	AT ashujohri connectionlostmamerrorsinermitochondriaconnectionsinneurodegenerativediseases AT abhishekchandra connectionlostmamerrorsinermitochondriaconnectionsinneurodegenerativediseases
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Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases

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