Efficacy of Tamsulosin in Relieving Double-J Stentrelated Symptoms: a Randomized Controlled Study

Introduction: Ureteral stent placement is an increasingly common procedure in urological practice. They are used for both prevention and treatment of ureteral obstruction. Despite improved design and materials, many patients still develop stent-related symptoms which commonly affect quality of life...

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Autores principales:	Deepak K Thakur, Suman Chapagain, Bhojraj Luitel, Pawan Raj Chalise, Uttam Kumar Sharma, Prem Raj Gyawali
Formato:	article
Lenguaje:	EN
Publicado:	Society of Surgeons of Nepal 2016
Materias:	DJ stent IPSS Tamsulosin VAS Surgery RD1-811
Acceso en línea:	https://doaj.org/article/7db6d97179cd4c00833d5898e958d66e
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spelling	oai:doaj.org-article:7db6d97179cd4c00833d5898e958d66e2021-12-05T19:16:26ZEfficacy of Tamsulosin in Relieving Double-J Stentrelated Symptoms: a Randomized Controlled Study10.3126/jssn.v19i2.245411815-39842392-4772https://doaj.org/article/7db6d97179cd4c00833d5898e958d66e2016-12-01T00:00:00Zhttps://www.nepjol.info/index.php/JSSN/article/view/24541https://doaj.org/toc/1815-3984https://doaj.org/toc/2392-4772 Introduction: Ureteral stent placement is an increasingly common procedure in urological practice. They are used for both prevention and treatment of ureteral obstruction. Despite improved design and materials, many patients still develop stent-related symptoms which commonly affect quality of life and sometimes necessitate early removal. Tamsulosin improves stent-related symptoms and quality of life. But such study has not been conducted in Nepalese context. In the present study, the effect of Tamsulosin in improving double-J stent-related symptoms and quality of life following ureteral stent placement was studied. Methods: This study was carried out in the Department of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal from February 2015 to January 2016. Forty six patients were included in the study and randomized into Tamsulosin (T) group and Control (C) group each having 23 patients. In addition to standard postoperative care, Tamsulosin group received 0.4 mg Tamsulosin daily for 2 weeks and Paracetamol on demand and control group received only Paracetamol (1gram/dose). Stent related symptoms and quality of life was assessed by International prostate symptom score (IPSS) at discharge (day2) and at the time of DJ stent removal (2 weeks). Pain was evaluated by visual analog scale (VAS) and analgesic requirement was documented. Data were analysed using Statistical Package for the Social Sciences (SPSS) 20, chisquare test and Student’s t- test was used. A p-value of <0.05 was considered significant. Results: Mean age in Tamsulosin group was 37.96±12.98 years and Control group 36.43± 10.99 years (p=0.67).There was no significant difference in IPSS (p=0.141), QoL index (p=0.089) and VAS (p=0.59) in the two groups at the time of discharge. At the time of DJ stent removal, IPSS (p<0.001), QoL index(p<0.001), VAS(p=0.004) and analgesic needed(p<0.001) was significantly lower in T group than in C group. Conclusion: Tamsulosin lowers stent related symptoms, pain and improves quality of life in patients with indwelling DJ stent though the effect is not immediate. Deepak K ThakurSuman ChapagainBhojraj LuitelPawan Raj ChaliseUttam Kumar SharmaPrem Raj GyawaliSociety of Surgeons of NepalarticleDJ stentIPSSTamsulosinVASSurgeryRD1-811ENJournal of Society of Surgeons of Nepal, Vol 19, Iss 2 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	DJ stent IPSS Tamsulosin VAS Surgery RD1-811
spellingShingle	DJ stent IPSS Tamsulosin VAS Surgery RD1-811 Deepak K Thakur Suman Chapagain Bhojraj Luitel Pawan Raj Chalise Uttam Kumar Sharma Prem Raj Gyawali Efficacy of Tamsulosin in Relieving Double-J Stentrelated Symptoms: a Randomized Controlled Study
description	Introduction: Ureteral stent placement is an increasingly common procedure in urological practice. They are used for both prevention and treatment of ureteral obstruction. Despite improved design and materials, many patients still develop stent-related symptoms which commonly affect quality of life and sometimes necessitate early removal. Tamsulosin improves stent-related symptoms and quality of life. But such study has not been conducted in Nepalese context. In the present study, the effect of Tamsulosin in improving double-J stent-related symptoms and quality of life following ureteral stent placement was studied. Methods: This study was carried out in the Department of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal from February 2015 to January 2016. Forty six patients were included in the study and randomized into Tamsulosin (T) group and Control (C) group each having 23 patients. In addition to standard postoperative care, Tamsulosin group received 0.4 mg Tamsulosin daily for 2 weeks and Paracetamol on demand and control group received only Paracetamol (1gram/dose). Stent related symptoms and quality of life was assessed by International prostate symptom score (IPSS) at discharge (day2) and at the time of DJ stent removal (2 weeks). Pain was evaluated by visual analog scale (VAS) and analgesic requirement was documented. Data were analysed using Statistical Package for the Social Sciences (SPSS) 20, chisquare test and Student’s t- test was used. A p-value of <0.05 was considered significant. Results: Mean age in Tamsulosin group was 37.96±12.98 years and Control group 36.43± 10.99 years (p=0.67).There was no significant difference in IPSS (p=0.141), QoL index (p=0.089) and VAS (p=0.59) in the two groups at the time of discharge. At the time of DJ stent removal, IPSS (p<0.001), QoL index(p<0.001), VAS(p=0.004) and analgesic needed(p<0.001) was significantly lower in T group than in C group. Conclusion: Tamsulosin lowers stent related symptoms, pain and improves quality of life in patients with indwelling DJ stent though the effect is not immediate.
format	article
author	Deepak K Thakur Suman Chapagain Bhojraj Luitel Pawan Raj Chalise Uttam Kumar Sharma Prem Raj Gyawali
author_facet	Deepak K Thakur Suman Chapagain Bhojraj Luitel Pawan Raj Chalise Uttam Kumar Sharma Prem Raj Gyawali
author_sort	Deepak K Thakur
title	Efficacy of Tamsulosin in Relieving Double-J Stentrelated Symptoms: a Randomized Controlled Study
title_short	Efficacy of Tamsulosin in Relieving Double-J Stentrelated Symptoms: a Randomized Controlled Study
title_full	Efficacy of Tamsulosin in Relieving Double-J Stentrelated Symptoms: a Randomized Controlled Study
title_fullStr	Efficacy of Tamsulosin in Relieving Double-J Stentrelated Symptoms: a Randomized Controlled Study
title_full_unstemmed	Efficacy of Tamsulosin in Relieving Double-J Stentrelated Symptoms: a Randomized Controlled Study
title_sort	efficacy of tamsulosin in relieving double-j stentrelated symptoms: a randomized controlled study
publisher	Society of Surgeons of Nepal
publishDate	2016
url	https://doaj.org/article/7db6d97179cd4c00833d5898e958d66e
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Efficacy of Tamsulosin in Relieving Double-J Stentrelated Symptoms: a Randomized Controlled Study

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