Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity

Antibodies against the platelet factor 4 (PF4) support bacterial host defence but in some cases may lead to heparin-induced thrombocytopenia (HIT). Nguyenet al.show that in autoimmune HIT a subset of antibodies binds strongly to PF4 causing its conformational change that leads to association of non-...

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Autores principales:	Thi-Huong Nguyen, Nikolay Medvedev, Mihaela Delcea, Andreas Greinacher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7db93bca16bf4fa1820e09bfd6b94d15
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spelling	oai:doaj.org-article:7db93bca16bf4fa1820e09bfd6b94d152021-12-02T14:40:24ZAnti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity10.1038/ncomms149452041-1723https://doaj.org/article/7db93bca16bf4fa1820e09bfd6b94d152017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms14945https://doaj.org/toc/2041-1723Antibodies against the platelet factor 4 (PF4) support bacterial host defence but in some cases may lead to heparin-induced thrombocytopenia (HIT). Nguyenet al.show that in autoimmune HIT a subset of antibodies binds strongly to PF4 causing its conformational change that leads to association of non-pathogenic PF4 antibodies and thrombotic platelet activation.Thi-Huong NguyenNikolay MedvedevMihaela DelceaAndreas GreinacherNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thi-Huong Nguyen Nikolay Medvedev Mihaela Delcea Andreas Greinacher Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity
description	Antibodies against the platelet factor 4 (PF4) support bacterial host defence but in some cases may lead to heparin-induced thrombocytopenia (HIT). Nguyenet al.show that in autoimmune HIT a subset of antibodies binds strongly to PF4 causing its conformational change that leads to association of non-pathogenic PF4 antibodies and thrombotic platelet activation.
format	article
author	Thi-Huong Nguyen Nikolay Medvedev Mihaela Delcea Andreas Greinacher
author_facet	Thi-Huong Nguyen Nikolay Medvedev Mihaela Delcea Andreas Greinacher
author_sort	Thi-Huong Nguyen
title	Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity
title_short	Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity
title_full	Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity
title_fullStr	Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity
title_full_unstemmed	Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity
title_sort	anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7db93bca16bf4fa1820e09bfd6b94d15
work_keys_str_mv	AT thihuongnguyen antiplateletfactor4polyanionantibodiesmediateanewmechanismofautoimmunity AT nikolaymedvedev antiplateletfactor4polyanionantibodiesmediateanewmechanismofautoimmunity AT mihaeladelcea antiplateletfactor4polyanionantibodiesmediateanewmechanismofautoimmunity AT andreasgreinacher antiplateletfactor4polyanionantibodiesmediateanewmechanismofautoimmunity
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Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity

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