ALTERED EXPRESSION OF SURFACE RECEPTORS AT EA.HY926 ENDOTHELIAL CELL LINE INDUCED WITH PLACENTAL SECRETORY FACTORS

Abstract. Placental cell populations produce a great variety of angiogenic factors and cytokines than control angiogenesis in placenta. Functional regulation of endothelial cells proceeds via modulation of endothelial cell receptors for endogenous angiogenic and apoptotic signals. Endothelial phenot...

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Autores principales:	O. I. Stepanova, T. U. L’vova, M. I. Mirashvili, K. N. Furaeva, D. I. Sokolov, S. A. Selkov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	endothelial cells angiogenic factors cytokines receptors placenta preeclampsia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7db969ef920f4de394a8525e9be60174
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spelling	oai:doaj.org-article:7db969ef920f4de394a8525e9be601742021-11-18T08:03:41ZALTERED EXPRESSION OF SURFACE RECEPTORS AT EA.HY926 ENDOTHELIAL CELL LINE INDUCED WITH PLACENTAL SECRETORY FACTORS1563-06252313-741X10.15789/1563-0625-2012-4-5-321-328https://doaj.org/article/7db969ef920f4de394a8525e9be601742014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/529https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Placental cell populations produce a great variety of angiogenic factors and cytokines than control angiogenesis in placenta. Functional regulation of endothelial cells proceeds via modulation of endothelial cell receptors for endogenous angiogenic and apoptotic signals. Endothelial phenotype alteration during normal pregnancy and in cases of preclampsia is not well understood. The goal of this investigation was to evaluate altered expression of angiogenic and cytokine receptors at EA.hy926 endothelial cells under the influence of placental tissue supernatants. Normal placental tissue supernatants from 1st and 3rd trimesters, and pre-eclamptic placental tissue supernatants (3rd trimester) stimulated angiogenic and cytokine receptors expression by the cultured endothelial cells, as compared with their background expression. Tissue supernatants from placental samples of 3rd trimester caused a decreased expression of angiogenic and cytokine receptors by endothelial cells, thus reflecting maturation of placental vascular system at these terms. Supernatants from preeclamptic placental tissue induced an increase of CD119 expression, in comparison with normal placental supernatants from the 3rd trimester. This finding suggests that IFNγ may be a factor of endothelial activation in pre-eclampsia. The study was supported by grants ГК №02.740.11.0711, НШ-3594.2010.7., and МД-150.2011.7.O. I. StepanovaT. U. L’vovaM. I. MirashviliK. N. FuraevaD. I. SokolovS. A. SelkovSPb RAACIarticleendothelial cellsangiogenic factorscytokinesreceptorsplacentapreeclampsiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 4-5, Pp 321-328 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	endothelial cells angiogenic factors cytokines receptors placenta preeclampsia Immunologic diseases. Allergy RC581-607
spellingShingle	endothelial cells angiogenic factors cytokines receptors placenta preeclampsia Immunologic diseases. Allergy RC581-607 O. I. Stepanova T. U. L’vova M. I. Mirashvili K. N. Furaeva D. I. Sokolov S. A. Selkov ALTERED EXPRESSION OF SURFACE RECEPTORS AT EA.HY926 ENDOTHELIAL CELL LINE INDUCED WITH PLACENTAL SECRETORY FACTORS
description	Abstract. Placental cell populations produce a great variety of angiogenic factors and cytokines than control angiogenesis in placenta. Functional regulation of endothelial cells proceeds via modulation of endothelial cell receptors for endogenous angiogenic and apoptotic signals. Endothelial phenotype alteration during normal pregnancy and in cases of preclampsia is not well understood. The goal of this investigation was to evaluate altered expression of angiogenic and cytokine receptors at EA.hy926 endothelial cells under the influence of placental tissue supernatants. Normal placental tissue supernatants from 1st and 3rd trimesters, and pre-eclamptic placental tissue supernatants (3rd trimester) stimulated angiogenic and cytokine receptors expression by the cultured endothelial cells, as compared with their background expression. Tissue supernatants from placental samples of 3rd trimester caused a decreased expression of angiogenic and cytokine receptors by endothelial cells, thus reflecting maturation of placental vascular system at these terms. Supernatants from preeclamptic placental tissue induced an increase of CD119 expression, in comparison with normal placental supernatants from the 3rd trimester. This finding suggests that IFNγ may be a factor of endothelial activation in pre-eclampsia. The study was supported by grants ГК №02.740.11.0711, НШ-3594.2010.7., and МД-150.2011.7.
format	article
author	O. I. Stepanova T. U. L’vova M. I. Mirashvili K. N. Furaeva D. I. Sokolov S. A. Selkov
author_facet	O. I. Stepanova T. U. L’vova M. I. Mirashvili K. N. Furaeva D. I. Sokolov S. A. Selkov
author_sort	O. I. Stepanova
title	ALTERED EXPRESSION OF SURFACE RECEPTORS AT EA.HY926 ENDOTHELIAL CELL LINE INDUCED WITH PLACENTAL SECRETORY FACTORS
title_short	ALTERED EXPRESSION OF SURFACE RECEPTORS AT EA.HY926 ENDOTHELIAL CELL LINE INDUCED WITH PLACENTAL SECRETORY FACTORS
title_full	ALTERED EXPRESSION OF SURFACE RECEPTORS AT EA.HY926 ENDOTHELIAL CELL LINE INDUCED WITH PLACENTAL SECRETORY FACTORS
title_fullStr	ALTERED EXPRESSION OF SURFACE RECEPTORS AT EA.HY926 ENDOTHELIAL CELL LINE INDUCED WITH PLACENTAL SECRETORY FACTORS
title_full_unstemmed	ALTERED EXPRESSION OF SURFACE RECEPTORS AT EA.HY926 ENDOTHELIAL CELL LINE INDUCED WITH PLACENTAL SECRETORY FACTORS
title_sort	altered expression of surface receptors at ea.hy926 endothelial cell line induced with placental secretory factors
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7db969ef920f4de394a8525e9be60174
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_version_	1718422487268589568

ALTERED EXPRESSION OF SURFACE RECEPTORS AT EA.HY926 ENDOTHELIAL CELL LINE INDUCED WITH PLACENTAL SECRETORY FACTORS

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