Green-synthesized silver nanoparticles with aqueous extract of green algae Chaetomorpha ligustica and its anticancer potential

Marine green algae are rich in various bioactive components with known anticancer activity. Some anticancer drugs present in green algae are in clinical trials nowadays. Algae-mediated silver nanoparticles (AgNPs) have been of a great interest in cancer treatment due to their unique physico-chemical...

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Autores principales:	Al-Zahrani Sabah Ahmed, Bhat Ramesa Shafi, Al Rashed Sarah A., Mahmood Amer, Al Fahad Ahmed, Alamro Ghadah, Almusallam Jamilah, Al Subki Roua, Orfali Raha, Al Daihan Sooad
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	chaetomorpha ligustica green algae silver nanoparticles cytotoxicity Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7db9d9afd4964eb3bbd9bc586fe1f55a
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spelling	oai:doaj.org-article:7db9d9afd4964eb3bbd9bc586fe1f55a2021-12-05T14:10:50ZGreen-synthesized silver nanoparticles with aqueous extract of green algae Chaetomorpha ligustica and its anticancer potential2191-955010.1515/gps-2021-0067https://doaj.org/article/7db9d9afd4964eb3bbd9bc586fe1f55a2021-11-01T00:00:00Zhttps://doi.org/10.1515/gps-2021-0067https://doaj.org/toc/2191-9550Marine green algae are rich in various bioactive components with known anticancer activity. Some anticancer drugs present in green algae are in clinical trials nowadays. Algae-mediated silver nanoparticles (AgNPs) have been of a great interest in cancer treatment due to their unique physico-chemical properties. In this study, we evaluate the anticancer efficiency of marine alga Chaetomorpha ligustica collected from the Arabian Gulf against colon cancer cell lines HT29 and HCT116. The anticancer potential of biosynthesized AgNPs from C. ligustica extract is also reported. Fourier transform infrared (FTIR) spectroscopy and gas chromatography-mass spectrometry analyses were used to identify the phytoconstituents present in algae extract. The synthesized AgNPs were confirmed via UV-Vis spectroscopy, whereas their morphology and stability were recorded by transmission electron microscopy (TEM), zeta potential, and zetasizer. We recorded absorption peak at 420 nm; TEM images showed an average size of 8.8 nm, whereas zeta potential and zetasizer study showed aggregation of nanoparticles. FTIR spectroscopy peaks of C. ligustica AgNPs were a little different from those of the C. ligustica extract. Both extracts showed cytotoxicity against cancer cell lines in a dose-dependent manner, but nanoparticles were found to be more toxic than algae extract. HT29 was found to be more sensitive than HCT116. For the first time, species of C. ligustica have been used and reported for the synthesis of nanoparticles. C. ligustica and its biogenic nanoparticles need to be scaled up for many biomedical applications especially in cancer research.Al-Zahrani Sabah AhmedBhat Ramesa ShafiAl Rashed Sarah A.Mahmood AmerAl Fahad AhmedAlamro GhadahAlmusallam JamilahAl Subki RouaOrfali RahaAl Daihan SooadDe Gruyterarticlechaetomorpha ligusticagreen algaesilver nanoparticlescytotoxicityChemistryQD1-999ENGreen Processing and Synthesis, Vol 10, Iss 1, Pp 711-721 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chaetomorpha ligustica green algae silver nanoparticles cytotoxicity Chemistry QD1-999
spellingShingle	chaetomorpha ligustica green algae silver nanoparticles cytotoxicity Chemistry QD1-999 Al-Zahrani Sabah Ahmed Bhat Ramesa Shafi Al Rashed Sarah A. Mahmood Amer Al Fahad Ahmed Alamro Ghadah Almusallam Jamilah Al Subki Roua Orfali Raha Al Daihan Sooad Green-synthesized silver nanoparticles with aqueous extract of green algae Chaetomorpha ligustica and its anticancer potential
description	Marine green algae are rich in various bioactive components with known anticancer activity. Some anticancer drugs present in green algae are in clinical trials nowadays. Algae-mediated silver nanoparticles (AgNPs) have been of a great interest in cancer treatment due to their unique physico-chemical properties. In this study, we evaluate the anticancer efficiency of marine alga Chaetomorpha ligustica collected from the Arabian Gulf against colon cancer cell lines HT29 and HCT116. The anticancer potential of biosynthesized AgNPs from C. ligustica extract is also reported. Fourier transform infrared (FTIR) spectroscopy and gas chromatography-mass spectrometry analyses were used to identify the phytoconstituents present in algae extract. The synthesized AgNPs were confirmed via UV-Vis spectroscopy, whereas their morphology and stability were recorded by transmission electron microscopy (TEM), zeta potential, and zetasizer. We recorded absorption peak at 420 nm; TEM images showed an average size of 8.8 nm, whereas zeta potential and zetasizer study showed aggregation of nanoparticles. FTIR spectroscopy peaks of C. ligustica AgNPs were a little different from those of the C. ligustica extract. Both extracts showed cytotoxicity against cancer cell lines in a dose-dependent manner, but nanoparticles were found to be more toxic than algae extract. HT29 was found to be more sensitive than HCT116. For the first time, species of C. ligustica have been used and reported for the synthesis of nanoparticles. C. ligustica and its biogenic nanoparticles need to be scaled up for many biomedical applications especially in cancer research.
format	article
author	Al-Zahrani Sabah Ahmed Bhat Ramesa Shafi Al Rashed Sarah A. Mahmood Amer Al Fahad Ahmed Alamro Ghadah Almusallam Jamilah Al Subki Roua Orfali Raha Al Daihan Sooad
author_facet	Al-Zahrani Sabah Ahmed Bhat Ramesa Shafi Al Rashed Sarah A. Mahmood Amer Al Fahad Ahmed Alamro Ghadah Almusallam Jamilah Al Subki Roua Orfali Raha Al Daihan Sooad
author_sort	Al-Zahrani Sabah Ahmed
title	Green-synthesized silver nanoparticles with aqueous extract of green algae Chaetomorpha ligustica and its anticancer potential
title_short	Green-synthesized silver nanoparticles with aqueous extract of green algae Chaetomorpha ligustica and its anticancer potential
title_full	Green-synthesized silver nanoparticles with aqueous extract of green algae Chaetomorpha ligustica and its anticancer potential
title_fullStr	Green-synthesized silver nanoparticles with aqueous extract of green algae Chaetomorpha ligustica and its anticancer potential
title_full_unstemmed	Green-synthesized silver nanoparticles with aqueous extract of green algae Chaetomorpha ligustica and its anticancer potential
title_sort	green-synthesized silver nanoparticles with aqueous extract of green algae chaetomorpha ligustica and its anticancer potential
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/7db9d9afd4964eb3bbd9bc586fe1f55a
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Green-synthesized silver nanoparticles with aqueous extract of green algae Chaetomorpha ligustica and its anticancer potential

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