Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

IFNγ secretion by CD8+T cells is critical for immunotherapy efficacy. In this study, the authors show that melanoma patients can become resistant to immunotherapy by acquiring chromosomal alterations and subsequent inactivating mutations in genes of the IFNγ signalling cascade, most often JAK1 or JA...

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Autores principales:	Antje Sucker, Fang Zhao, Natalia Pieper, Christina Heeke, Raffaela Maltaner, Nadine Stadtler, Birgit Real, Nicola Bielefeld, Sebastian Howe, Benjamin Weide, Ralf Gutzmer, Jochen Utikal, Carmen Loquai, Helen Gogas, Ludger Klein-Hitpass, Michael Zeschnigk, Astrid M. Westendorf, Mirko Trilling, Susanne Horn, Bastian Schilling, Dirk Schadendorf, Klaus G. Griewank, Annette Paschen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7dba103f7a864f4c8cb9130aa2e816d2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:7dba103f7a864f4c8cb9130aa2e816d22021-12-02T14:42:06ZAcquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions10.1038/ncomms154402041-1723https://doaj.org/article/7dba103f7a864f4c8cb9130aa2e816d22017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15440https://doaj.org/toc/2041-1723IFNγ secretion by CD8+T cells is critical for immunotherapy efficacy. In this study, the authors show that melanoma patients can become resistant to immunotherapy by acquiring chromosomal alterations and subsequent inactivating mutations in genes of the IFNγ signalling cascade, most often JAK1 or JAK2.Antje SuckerFang ZhaoNatalia PieperChristina HeekeRaffaela MaltanerNadine StadtlerBirgit RealNicola BielefeldSebastian HoweBenjamin WeideRalf GutzmerJochen UtikalCarmen LoquaiHelen GogasLudger Klein-HitpassMichael ZeschnigkAstrid M. WestendorfMirko TrillingSusanne HornBastian SchillingDirk SchadendorfKlaus G. GriewankAnnette PaschenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antje Sucker Fang Zhao Natalia Pieper Christina Heeke Raffaela Maltaner Nadine Stadtler Birgit Real Nicola Bielefeld Sebastian Howe Benjamin Weide Ralf Gutzmer Jochen Utikal Carmen Loquai Helen Gogas Ludger Klein-Hitpass Michael Zeschnigk Astrid M. Westendorf Mirko Trilling Susanne Horn Bastian Schilling Dirk Schadendorf Klaus G. Griewank Annette Paschen Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
description	IFNγ secretion by CD8+T cells is critical for immunotherapy efficacy. In this study, the authors show that melanoma patients can become resistant to immunotherapy by acquiring chromosomal alterations and subsequent inactivating mutations in genes of the IFNγ signalling cascade, most often JAK1 or JAK2.
format	article
author	Antje Sucker Fang Zhao Natalia Pieper Christina Heeke Raffaela Maltaner Nadine Stadtler Birgit Real Nicola Bielefeld Sebastian Howe Benjamin Weide Ralf Gutzmer Jochen Utikal Carmen Loquai Helen Gogas Ludger Klein-Hitpass Michael Zeschnigk Astrid M. Westendorf Mirko Trilling Susanne Horn Bastian Schilling Dirk Schadendorf Klaus G. Griewank Annette Paschen
author_facet	Antje Sucker Fang Zhao Natalia Pieper Christina Heeke Raffaela Maltaner Nadine Stadtler Birgit Real Nicola Bielefeld Sebastian Howe Benjamin Weide Ralf Gutzmer Jochen Utikal Carmen Loquai Helen Gogas Ludger Klein-Hitpass Michael Zeschnigk Astrid M. Westendorf Mirko Trilling Susanne Horn Bastian Schilling Dirk Schadendorf Klaus G. Griewank Annette Paschen
author_sort	Antje Sucker
title	Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
title_short	Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
title_full	Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
title_fullStr	Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
title_full_unstemmed	Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
title_sort	acquired ifnγ resistance impairs anti-tumor immunity and gives rise to t-cell-resistant melanoma lesions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7dba103f7a864f4c8cb9130aa2e816d2
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Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

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