Recent Advances in Macrophage-Mediated Drug Delivery Systems

Tiantian Liang,1,* Rongtao Zhang,1,* Xianbin Liu,1,* Qian Ding,1 Siqiong Wu,1 Chunhong Li,2 Yan Lin,2 Yun Ye,1 Zhirong Zhong,2 Meiling Zhou1 1Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 2Department of...

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Autores principales:	Liang T, Zhang R, Liu X, Ding Q, Wu S, Li C, Lin Y, Ye Y, Zhong Z, Zhou M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	macrophage macrophage membranes drug delivery systems inflammation tumor biomimetic Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7dbbe8f6b622440580337bf7a5542aed
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spelling	oai:doaj.org-article:7dbbe8f6b622440580337bf7a5542aed2021-12-02T15:39:44ZRecent Advances in Macrophage-Mediated Drug Delivery Systems1178-2013https://doaj.org/article/7dbbe8f6b622440580337bf7a5542aed2021-04-01T00:00:00Zhttps://www.dovepress.com/recent-advances-in-macrophage-mediated-drug-delivery-systems-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Tiantian Liang,1,* Rongtao Zhang,1,* Xianbin Liu,1,* Qian Ding,1 Siqiong Wu,1 Chunhong Li,2 Yan Lin,2 Yun Ye,1 Zhirong Zhong,2 Meiling Zhou1 1Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 2Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meiling ZhouDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, Sichuan, 646000, People’s Republic of ChinaEmail meilzhou@163.comZhirong ZhongDepartment of Pharmaceutical, Sciences School of Pharmacy, Southwest Medical University, No. 319 Zhongshan Road Jiangyang District, Luzhou, Sichuan, 646000, People’s Republic of ChinaEmail zhongzhirong@126.comAbstract: Macrophages have been extensively used in the development of drug delivery systems, as they can prolong the circulation and release of drugs, extend their half-life, increase their stability and targeting ability, and reduce immunogenicity. Moreover, they have good biocompatibility and degradability and offer abundant surface receptors for targeted delivery of a wide variety of drugs. Macrophage-mediated drug delivery systems can be prepared by loading drugs or drug-loaded nanoparticles into macrophages, macrophage membranes or macrophage-derived vesicles. Although such systems can be used to treat inflammation, cancer, HIV infection and other diseases, they require further research and optimization since they have been assembled from diverse sources and therefore can have quite different physical and chemical properties. Moreover, potential cell-drug interactions can limit their application, and the biological activity of membrane proteins might be lost during membrane extraction and storage. In this review, we summarize the recent advances in this field and discuss the preparation of macrophage-mediated drug delivery systems, their advantages over other delivery systems, their potential applications and future lines of research.Keywords: macrophage, macrophage membranes, drug delivery systems, inflammation, tumor, biomimeticLiang TZhang RLiu XDing QWu SLi CLin YYe YZhong ZZhou MDove Medical Pressarticlemacrophagemacrophage membranesdrug delivery systemsinflammationtumorbiomimeticMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 2703-2714 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	macrophage macrophage membranes drug delivery systems inflammation tumor biomimetic Medicine (General) R5-920
spellingShingle	macrophage macrophage membranes drug delivery systems inflammation tumor biomimetic Medicine (General) R5-920 Liang T Zhang R Liu X Ding Q Wu S Li C Lin Y Ye Y Zhong Z Zhou M Recent Advances in Macrophage-Mediated Drug Delivery Systems
description	Tiantian Liang,1,* Rongtao Zhang,1,* Xianbin Liu,1,* Qian Ding,1 Siqiong Wu,1 Chunhong Li,2 Yan Lin,2 Yun Ye,1 Zhirong Zhong,2 Meiling Zhou1 1Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China; 2Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meiling ZhouDepartment of Pharmacy, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Luzhou, Sichuan, 646000, People’s Republic of ChinaEmail meilzhou@163.comZhirong ZhongDepartment of Pharmaceutical, Sciences School of Pharmacy, Southwest Medical University, No. 319 Zhongshan Road Jiangyang District, Luzhou, Sichuan, 646000, People’s Republic of ChinaEmail zhongzhirong@126.comAbstract: Macrophages have been extensively used in the development of drug delivery systems, as they can prolong the circulation and release of drugs, extend their half-life, increase their stability and targeting ability, and reduce immunogenicity. Moreover, they have good biocompatibility and degradability and offer abundant surface receptors for targeted delivery of a wide variety of drugs. Macrophage-mediated drug delivery systems can be prepared by loading drugs or drug-loaded nanoparticles into macrophages, macrophage membranes or macrophage-derived vesicles. Although such systems can be used to treat inflammation, cancer, HIV infection and other diseases, they require further research and optimization since they have been assembled from diverse sources and therefore can have quite different physical and chemical properties. Moreover, potential cell-drug interactions can limit their application, and the biological activity of membrane proteins might be lost during membrane extraction and storage. In this review, we summarize the recent advances in this field and discuss the preparation of macrophage-mediated drug delivery systems, their advantages over other delivery systems, their potential applications and future lines of research.Keywords: macrophage, macrophage membranes, drug delivery systems, inflammation, tumor, biomimetic
format	article
author	Liang T Zhang R Liu X Ding Q Wu S Li C Lin Y Ye Y Zhong Z Zhou M
author_facet	Liang T Zhang R Liu X Ding Q Wu S Li C Lin Y Ye Y Zhong Z Zhou M
author_sort	Liang T
title	Recent Advances in Macrophage-Mediated Drug Delivery Systems
title_short	Recent Advances in Macrophage-Mediated Drug Delivery Systems
title_full	Recent Advances in Macrophage-Mediated Drug Delivery Systems
title_fullStr	Recent Advances in Macrophage-Mediated Drug Delivery Systems
title_full_unstemmed	Recent Advances in Macrophage-Mediated Drug Delivery Systems
title_sort	recent advances in macrophage-mediated drug delivery systems
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7dbbe8f6b622440580337bf7a5542aed
work_keys_str_mv	AT liangt recentadvancesinmacrophagemediateddrugdeliverysystems AT zhangr recentadvancesinmacrophagemediateddrugdeliverysystems AT liux recentadvancesinmacrophagemediateddrugdeliverysystems AT dingq recentadvancesinmacrophagemediateddrugdeliverysystems AT wus recentadvancesinmacrophagemediateddrugdeliverysystems AT lic recentadvancesinmacrophagemediateddrugdeliverysystems AT liny recentadvancesinmacrophagemediateddrugdeliverysystems AT yey recentadvancesinmacrophagemediateddrugdeliverysystems AT zhongz recentadvancesinmacrophagemediateddrugdeliverysystems AT zhoum recentadvancesinmacrophagemediateddrugdeliverysystems
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Recent Advances in Macrophage-Mediated Drug Delivery Systems

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