Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis.

<h4>Background</h4>The involvement of cytokines in schizophrenia (SZ) has been proposed in recent years and various studies have accumulated convergent lines of evidence. Among which, the role of interleukin-10 (IL-10) in SZ has been explored in a number of studies by investigating assoc...

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Autores principales:	Lei Gao, Zhao Li, Suhua Chang, Jing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7dbc04e71d454cb5afd429d0e1f7042e
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spelling	oai:doaj.org-article:7dbc04e71d454cb5afd429d0e1f7042e2021-11-18T08:29:22ZAssociation of interleukin-10 polymorphisms with schizophrenia: a meta-analysis.1932-620310.1371/journal.pone.0090407https://doaj.org/article/7dbc04e71d454cb5afd429d0e1f7042e2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24603720/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The involvement of cytokines in schizophrenia (SZ) has been proposed in recent years and various studies have accumulated convergent lines of evidence. Among which, the role of interleukin-10 (IL-10) in SZ has been explored in a number of studies by investigating association of single nucleotide polymorphisms (SNPs) and susceptibility of SZ. However, the results are inconsistent since its power is limited by the individual sample size. To evaluate the overall effect between them, we conducted a meta-analysis by combining all available studies.<h4>Methods</h4>Studies were searched from the database of PubMed, PsycINFO and ISI web of Knowledge up to Nov 2013. The meta-analysis was conducted based on statement of preferred reporting items for systematic reviews and meta-analyses (PRISMA).<h4>Results</h4>Eleven studies including 6399 subjects (3129 cases and 3270 controls) were available for the meta-analysis. Among three investigated SNPs, rs1800872 was observed to be significantly associated with risk of SZ (AA vs. AC+CC, Pooled OR = 1.351, P-value = 2.06E-04). Meanwhile, among six haplotypes of rs1800896 - rs1800871 - rs1800872, significant associations were observed in haplotype A-C-A (Pooled OR = 1.762, P-value = 2.00E-03) and G-C-C (Pooled OR = 0.649, P-value = 2.00E-03) for Asians. These results were still significant after adjusting for multiple comparisons.<h4>Conclusions</h4>This meta-analysis demonstrated an SNP and two haplotypes of IL-10 significantly associated with SZ, suggesting that IL-10 might be a risk factor of SZ.Lei GaoZhao LiSuhua ChangJing WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90407 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lei Gao Zhao Li Suhua Chang Jing Wang Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis.
description	<h4>Background</h4>The involvement of cytokines in schizophrenia (SZ) has been proposed in recent years and various studies have accumulated convergent lines of evidence. Among which, the role of interleukin-10 (IL-10) in SZ has been explored in a number of studies by investigating association of single nucleotide polymorphisms (SNPs) and susceptibility of SZ. However, the results are inconsistent since its power is limited by the individual sample size. To evaluate the overall effect between them, we conducted a meta-analysis by combining all available studies.<h4>Methods</h4>Studies were searched from the database of PubMed, PsycINFO and ISI web of Knowledge up to Nov 2013. The meta-analysis was conducted based on statement of preferred reporting items for systematic reviews and meta-analyses (PRISMA).<h4>Results</h4>Eleven studies including 6399 subjects (3129 cases and 3270 controls) were available for the meta-analysis. Among three investigated SNPs, rs1800872 was observed to be significantly associated with risk of SZ (AA vs. AC+CC, Pooled OR = 1.351, P-value = 2.06E-04). Meanwhile, among six haplotypes of rs1800896 - rs1800871 - rs1800872, significant associations were observed in haplotype A-C-A (Pooled OR = 1.762, P-value = 2.00E-03) and G-C-C (Pooled OR = 0.649, P-value = 2.00E-03) for Asians. These results were still significant after adjusting for multiple comparisons.<h4>Conclusions</h4>This meta-analysis demonstrated an SNP and two haplotypes of IL-10 significantly associated with SZ, suggesting that IL-10 might be a risk factor of SZ.
format	article
author	Lei Gao Zhao Li Suhua Chang Jing Wang
author_facet	Lei Gao Zhao Li Suhua Chang Jing Wang
author_sort	Lei Gao
title	Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis.
title_short	Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis.
title_full	Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis.
title_fullStr	Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis.
title_full_unstemmed	Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis.
title_sort	association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7dbc04e71d454cb5afd429d0e1f7042e
work_keys_str_mv	AT leigao associationofinterleukin10polymorphismswithschizophreniaametaanalysis AT zhaoli associationofinterleukin10polymorphismswithschizophreniaametaanalysis AT suhuachang associationofinterleukin10polymorphismswithschizophreniaametaanalysis AT jingwang associationofinterleukin10polymorphismswithschizophreniaametaanalysis
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Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis.

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