Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia

Abstract Heterogeneity in malaria risk is considered a challenge for malaria elimination. A cross-sectional study was conducted to describe and explain micro-epidemiological variation in Plasmodium infection prevalence at household and village level in three villages in Ratanakiri Province, Cambodia...

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Autores principales:	Melanie Bannister-Tyrrell, Set Srun, Vincent Sluydts, Charlotte Gryseels, Vanna Mean, Saorin Kim, Mao Sokny, Koen Peeters Grietens, Marc Coosemans, Didier Menard, Sochantha Tho, Wim Van Bortel, Lies Durnez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7dbda5c5ec1b4623bb85f41a1f50a4b2
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spelling	oai:doaj.org-article:7dbda5c5ec1b4623bb85f41a1f50a4b22021-12-02T15:09:01ZImportance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia10.1038/s41598-018-30193-32045-2322https://doaj.org/article/7dbda5c5ec1b4623bb85f41a1f50a4b22018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30193-3https://doaj.org/toc/2045-2322Abstract Heterogeneity in malaria risk is considered a challenge for malaria elimination. A cross-sectional study was conducted to describe and explain micro-epidemiological variation in Plasmodium infection prevalence at household and village level in three villages in Ratanakiri Province, Cambodia. A two-level logistic regression model with a random intercept fitted for each household was used to model the odds of Plasmodium infection, with sequential adjustment for individual-level then household-level risk factors. Individual-level risk factors for Plasmodium infection included hammock net use and frequency of evening outdoor farm gatherings in adults, and older age in children. Household-level risk factors included house wall material, crop types, and satellite dish and farm machine ownership. Individual-level risk factors did not explain differences in odds of Plasmodium infection between households or between villages. In contrast, once household-level risk factors were taken into account, there was no significant difference in odds of Plasmodium infection between households and between villages. This study shows the importance of ongoing indoor and peridomestic transmission in a region where forest workers and mobile populations have previously been the focus of attention. Interventions targeting malaria risk at household level should be further explored.Melanie Bannister-TyrrellSet SrunVincent SluydtsCharlotte GryseelsVanna MeanSaorin KimMao SoknyKoen Peeters GrietensMarc CoosemansDidier MenardSochantha ThoWim Van BortelLies DurnezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Melanie Bannister-Tyrrell Set Srun Vincent Sluydts Charlotte Gryseels Vanna Mean Saorin Kim Mao Sokny Koen Peeters Grietens Marc Coosemans Didier Menard Sochantha Tho Wim Van Bortel Lies Durnez Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia
description	Abstract Heterogeneity in malaria risk is considered a challenge for malaria elimination. A cross-sectional study was conducted to describe and explain micro-epidemiological variation in Plasmodium infection prevalence at household and village level in three villages in Ratanakiri Province, Cambodia. A two-level logistic regression model with a random intercept fitted for each household was used to model the odds of Plasmodium infection, with sequential adjustment for individual-level then household-level risk factors. Individual-level risk factors for Plasmodium infection included hammock net use and frequency of evening outdoor farm gatherings in adults, and older age in children. Household-level risk factors included house wall material, crop types, and satellite dish and farm machine ownership. Individual-level risk factors did not explain differences in odds of Plasmodium infection between households or between villages. In contrast, once household-level risk factors were taken into account, there was no significant difference in odds of Plasmodium infection between households and between villages. This study shows the importance of ongoing indoor and peridomestic transmission in a region where forest workers and mobile populations have previously been the focus of attention. Interventions targeting malaria risk at household level should be further explored.
format	article
author	Melanie Bannister-Tyrrell Set Srun Vincent Sluydts Charlotte Gryseels Vanna Mean Saorin Kim Mao Sokny Koen Peeters Grietens Marc Coosemans Didier Menard Sochantha Tho Wim Van Bortel Lies Durnez
author_facet	Melanie Bannister-Tyrrell Set Srun Vincent Sluydts Charlotte Gryseels Vanna Mean Saorin Kim Mao Sokny Koen Peeters Grietens Marc Coosemans Didier Menard Sochantha Tho Wim Van Bortel Lies Durnez
author_sort	Melanie Bannister-Tyrrell
title	Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia
title_short	Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia
title_full	Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia
title_fullStr	Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia
title_full_unstemmed	Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia
title_sort	importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in ratanakiri province, cambodia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7dbda5c5ec1b4623bb85f41a1f50a4b2
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Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia

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