The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds

Abstract Regeneration/repair after injury can be endowed by adult stem cells (ASCs) or lineage restricted and even terminally differentiated cells. In corneal epithelium, regeneration after a large wound depends on ASCs (limbal epithelial stem cells, LESCs), whereas repair after a small wound is LES...

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Autores principales:	Yijian Li, Lingling Ge, Xia Chen, Yumei Mao, Xianliang Gu, Bangqi Ren, Yuxiao Zeng, Min Chen, Siyu Chen, Jinhua Liu, Yuli Yang, Haiwei Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/7dbdfec2c67b4eb3832a6115939375b0
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spelling	oai:doaj.org-article:7dbdfec2c67b4eb3832a6115939375b02021-12-02T16:35:53ZThe common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds10.1038/s41536-021-00126-22057-3995https://doaj.org/article/7dbdfec2c67b4eb3832a6115939375b02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00126-2https://doaj.org/toc/2057-3995Abstract Regeneration/repair after injury can be endowed by adult stem cells (ASCs) or lineage restricted and even terminally differentiated cells. In corneal epithelium, regeneration after a large wound depends on ASCs (limbal epithelial stem cells, LESCs), whereas repair after a small wound is LESCs-independent. Here, using rat corneal epithelial wounds with different sizes, we show that YAP activation promotes the activation and expansion of LESCs after a large wound, as well as the reprogramming of local epithelial cells (repairing epithelial cells) after a small wound, which contributes to LESCs-dependent and -independent wound healing, respectively. Mechanically, we highlight that the reciprocal regulation of YAP activity and the assembly of cell junction and cortical F-actin cytoskeleton accelerates corneal epithelial healing with different-sized wounds. Together, the common YAP activation and the underlying regulatory mechanism are harnessed by LESCs and lineage-restricted epithelial cells to cope with corneal epithelial wounds with different sizes.Yijian LiLingling GeXia ChenYumei MaoXianliang GuBangqi RenYuxiao ZengMin ChenSiyu ChenJinhua LiuYuli YangHaiwei XuNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Yijian Li Lingling Ge Xia Chen Yumei Mao Xianliang Gu Bangqi Ren Yuxiao Zeng Min Chen Siyu Chen Jinhua Liu Yuli Yang Haiwei Xu The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds
description	Abstract Regeneration/repair after injury can be endowed by adult stem cells (ASCs) or lineage restricted and even terminally differentiated cells. In corneal epithelium, regeneration after a large wound depends on ASCs (limbal epithelial stem cells, LESCs), whereas repair after a small wound is LESCs-independent. Here, using rat corneal epithelial wounds with different sizes, we show that YAP activation promotes the activation and expansion of LESCs after a large wound, as well as the reprogramming of local epithelial cells (repairing epithelial cells) after a small wound, which contributes to LESCs-dependent and -independent wound healing, respectively. Mechanically, we highlight that the reciprocal regulation of YAP activity and the assembly of cell junction and cortical F-actin cytoskeleton accelerates corneal epithelial healing with different-sized wounds. Together, the common YAP activation and the underlying regulatory mechanism are harnessed by LESCs and lineage-restricted epithelial cells to cope with corneal epithelial wounds with different sizes.
format	article
author	Yijian Li Lingling Ge Xia Chen Yumei Mao Xianliang Gu Bangqi Ren Yuxiao Zeng Min Chen Siyu Chen Jinhua Liu Yuli Yang Haiwei Xu
author_facet	Yijian Li Lingling Ge Xia Chen Yumei Mao Xianliang Gu Bangqi Ren Yuxiao Zeng Min Chen Siyu Chen Jinhua Liu Yuli Yang Haiwei Xu
author_sort	Yijian Li
title	The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds
title_short	The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds
title_full	The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds
title_fullStr	The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds
title_full_unstemmed	The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds
title_sort	common yap activation mediates corneal epithelial regeneration and repair with different-sized wounds
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7dbdfec2c67b4eb3832a6115939375b0
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The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds

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