Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential

Oluyomi Stephen Adeyemi,1,2 Yuho Murata,1 Tatsuki Sugi,1 Kentaro Kato1 1National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan; 2Medicinal Biochemistry and Toxicology Laboratory, Department of Biological Sciences, Landmark Universi...

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Autores principales:	Adeyemi OS, Murata Y, Sugi T, Kato K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Anti-parasite Drug screening Nanomedicine Toxoplasmosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7dc1be810a054ae7b79f2a6d839b2e04
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spelling	oai:doaj.org-article:7dc1be810a054ae7b79f2a6d839b2e042021-12-02T07:13:41ZInorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential1178-2013https://doaj.org/article/7dc1be810a054ae7b79f2a6d839b2e042017-02-01T00:00:00Zhttps://www.dovepress.com/inorganic-nanoparticles-kill-toxoplasma-gondii-via-changes-in-redox-st-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Oluyomi Stephen Adeyemi,1,2 Yuho Murata,1 Tatsuki Sugi,1 Kentaro Kato1 1National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan; 2Medicinal Biochemistry and Toxicology Laboratory, Department of Biological Sciences, Landmark University, Omu-Aran, Nigeria Abstract: This study evaluated the anti-Toxoplasma gondii potential of gold, silver, and platinum nanoparticles (NPs). Inorganic NPs (0.01–1,000 µg/mL) were screened for antiparasitic activity. The NPs caused >90% inhibition of T. gondii growth with EC50 values of ≤7, ≤1, and ≤100 µg/mL for gold, silver, and platinum NPs, respectively. The NPs showed no host cell cytotoxicity at the effective anti-T. gondii concentrations; the estimated selectivity index revealed a ≥20-fold activity toward the parasite versus the host cell. The anti-T. gondii activity of the NPs, which may be linked to redox signaling, affected the parasite mitochondrial membrane potential and parasite invasion, replication, recovery, and infectivity potential. Our results demonstrated the antiparasitic potential of NPs. The findings support the further exploration of NPs as a possible source of alternative and effective anti-T. gondii agents. Keywords: antiparasite, drug screening, nanomedicine, toxoplasmosisAdeyemi OSMurata YSugi TKato KDove Medical PressarticleAnti-parasiteDrug screeningNanomedicineToxoplasmosisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1647-1661 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anti-parasite Drug screening Nanomedicine Toxoplasmosis Medicine (General) R5-920
spellingShingle	Anti-parasite Drug screening Nanomedicine Toxoplasmosis Medicine (General) R5-920 Adeyemi OS Murata Y Sugi T Kato K Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential
description	Oluyomi Stephen Adeyemi,1,2 Yuho Murata,1 Tatsuki Sugi,1 Kentaro Kato1 1National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan; 2Medicinal Biochemistry and Toxicology Laboratory, Department of Biological Sciences, Landmark University, Omu-Aran, Nigeria Abstract: This study evaluated the anti-Toxoplasma gondii potential of gold, silver, and platinum nanoparticles (NPs). Inorganic NPs (0.01–1,000 µg/mL) were screened for antiparasitic activity. The NPs caused >90% inhibition of T. gondii growth with EC50 values of ≤7, ≤1, and ≤100 µg/mL for gold, silver, and platinum NPs, respectively. The NPs showed no host cell cytotoxicity at the effective anti-T. gondii concentrations; the estimated selectivity index revealed a ≥20-fold activity toward the parasite versus the host cell. The anti-T. gondii activity of the NPs, which may be linked to redox signaling, affected the parasite mitochondrial membrane potential and parasite invasion, replication, recovery, and infectivity potential. Our results demonstrated the antiparasitic potential of NPs. The findings support the further exploration of NPs as a possible source of alternative and effective anti-T. gondii agents. Keywords: antiparasite, drug screening, nanomedicine, toxoplasmosis
format	article
author	Adeyemi OS Murata Y Sugi T Kato K
author_facet	Adeyemi OS Murata Y Sugi T Kato K
author_sort	Adeyemi OS
title	Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential
title_short	Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential
title_full	Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential
title_fullStr	Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential
title_full_unstemmed	Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential
title_sort	inorganic nanoparticles kill toxoplasma gondii via changes in redox status and mitochondrial membrane potential
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/7dc1be810a054ae7b79f2a6d839b2e04
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_version_	1718399580369846272

Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential

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