Evolutionary dynamics of circular RNAs in primates

Many primate genes produce circular RNAs (circRNAs). However, the extent of circRNA conservation between closely related species remains unclear. By comparing tissue-specific transcriptomes across over 70 million years of primate evolution, we identify that within 3 million years circRNA expression...

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Autores principales:	Gabriela Santos-Rodriguez, Irina Voineagu, Robert J Weatheritt
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	circRNA comparative genomics RNA evolution non-coding RNAs Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7dc1edc7e3aa4f13bfbac1adc237b2dc
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spelling	oai:doaj.org-article:7dc1edc7e3aa4f13bfbac1adc237b2dc2021-11-26T11:14:14ZEvolutionary dynamics of circular RNAs in primates10.7554/eLife.691482050-084Xe69148https://doaj.org/article/7dc1edc7e3aa4f13bfbac1adc237b2dc2021-09-01T00:00:00Zhttps://elifesciences.org/articles/69148https://doaj.org/toc/2050-084XMany primate genes produce circular RNAs (circRNAs). However, the extent of circRNA conservation between closely related species remains unclear. By comparing tissue-specific transcriptomes across over 70 million years of primate evolution, we identify that within 3 million years circRNA expression profiles diverged such that they are more related to species identity than organ type. However, our analysis also revealed a subset of circRNAs with conserved neural expression across tens of millions of years of evolution. By comparing to species-specific circRNAs, we identified that the downstream intron of the conserved circRNAs display a dramatic lengthening during evolution due to the insertion of novel retrotransposons. Our work provides comparative analyses of the mechanisms promoting circRNAs to generate increased transcriptomic complexity in primates.Gabriela Santos-RodriguezIrina VoineaguRobert J WeatheritteLife Sciences Publications LtdarticlecircRNAcomparative genomicsRNAevolutionnon-coding RNAsMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circRNA comparative genomics RNA evolution non-coding RNAs Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	circRNA comparative genomics RNA evolution non-coding RNAs Medicine R Science Q Biology (General) QH301-705.5 Gabriela Santos-Rodriguez Irina Voineagu Robert J Weatheritt Evolutionary dynamics of circular RNAs in primates
description	Many primate genes produce circular RNAs (circRNAs). However, the extent of circRNA conservation between closely related species remains unclear. By comparing tissue-specific transcriptomes across over 70 million years of primate evolution, we identify that within 3 million years circRNA expression profiles diverged such that they are more related to species identity than organ type. However, our analysis also revealed a subset of circRNAs with conserved neural expression across tens of millions of years of evolution. By comparing to species-specific circRNAs, we identified that the downstream intron of the conserved circRNAs display a dramatic lengthening during evolution due to the insertion of novel retrotransposons. Our work provides comparative analyses of the mechanisms promoting circRNAs to generate increased transcriptomic complexity in primates.
format	article
author	Gabriela Santos-Rodriguez Irina Voineagu Robert J Weatheritt
author_facet	Gabriela Santos-Rodriguez Irina Voineagu Robert J Weatheritt
author_sort	Gabriela Santos-Rodriguez
title	Evolutionary dynamics of circular RNAs in primates
title_short	Evolutionary dynamics of circular RNAs in primates
title_full	Evolutionary dynamics of circular RNAs in primates
title_fullStr	Evolutionary dynamics of circular RNAs in primates
title_full_unstemmed	Evolutionary dynamics of circular RNAs in primates
title_sort	evolutionary dynamics of circular rnas in primates
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/7dc1edc7e3aa4f13bfbac1adc237b2dc
work_keys_str_mv	AT gabrielasantosrodriguez evolutionarydynamicsofcircularrnasinprimates AT irinavoineagu evolutionarydynamicsofcircularrnasinprimates AT robertjweatheritt evolutionarydynamicsofcircularrnasinprimates
_version_	1718409544185413632

Evolutionary dynamics of circular RNAs in primates

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