Probabilistic controllability approach to metabolic fluxes in normal and cancer tissues

Metabolic rewiring is a feature of many cancers. Here, the authors combine control theory and flux correlation analysis to study the transition of healthy metabolic networks to cancer states, and find that cancer metabolism is characterized by more streamlined flux distributions.

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Detalles Bibliográficos
Autores principales: Jean-Marc Schwartz, Hiroaki Otokuni, Tatsuya Akutsu, Jose C. Nacher
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7dc3ee3bfaa04a9794f00cfbcdbd88c3
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Sumario:Metabolic rewiring is a feature of many cancers. Here, the authors combine control theory and flux correlation analysis to study the transition of healthy metabolic networks to cancer states, and find that cancer metabolism is characterized by more streamlined flux distributions.