Probabilistic controllability approach to metabolic fluxes in normal and cancer tissues

Metabolic rewiring is a feature of many cancers. Here, the authors combine control theory and flux correlation analysis to study the transition of healthy metabolic networks to cancer states, and find that cancer metabolism is characterized by more streamlined flux distributions.

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Detalles Bibliográficos
Autores principales:	Jean-Marc Schwartz, Hiroaki Otokuni, Tatsuya Akutsu, Jose C. Nacher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7dc3ee3bfaa04a9794f00cfbcdbd88c3
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spelling	oai:doaj.org-article:7dc3ee3bfaa04a9794f00cfbcdbd88c32021-12-02T15:35:52ZProbabilistic controllability approach to metabolic fluxes in normal and cancer tissues10.1038/s41467-019-10616-z2041-1723https://doaj.org/article/7dc3ee3bfaa04a9794f00cfbcdbd88c32019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10616-zhttps://doaj.org/toc/2041-1723Metabolic rewiring is a feature of many cancers. Here, the authors combine control theory and flux correlation analysis to study the transition of healthy metabolic networks to cancer states, and find that cancer metabolism is characterized by more streamlined flux distributions.Jean-Marc SchwartzHiroaki OtokuniTatsuya AkutsuJose C. NacherNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jean-Marc Schwartz Hiroaki Otokuni Tatsuya Akutsu Jose C. Nacher Probabilistic controllability approach to metabolic fluxes in normal and cancer tissues
description	Metabolic rewiring is a feature of many cancers. Here, the authors combine control theory and flux correlation analysis to study the transition of healthy metabolic networks to cancer states, and find that cancer metabolism is characterized by more streamlined flux distributions.
format	article
author	Jean-Marc Schwartz Hiroaki Otokuni Tatsuya Akutsu Jose C. Nacher
author_facet	Jean-Marc Schwartz Hiroaki Otokuni Tatsuya Akutsu Jose C. Nacher
author_sort	Jean-Marc Schwartz
title	Probabilistic controllability approach to metabolic fluxes in normal and cancer tissues
title_short	Probabilistic controllability approach to metabolic fluxes in normal and cancer tissues
title_full	Probabilistic controllability approach to metabolic fluxes in normal and cancer tissues
title_fullStr	Probabilistic controllability approach to metabolic fluxes in normal and cancer tissues
title_full_unstemmed	Probabilistic controllability approach to metabolic fluxes in normal and cancer tissues
title_sort	probabilistic controllability approach to metabolic fluxes in normal and cancer tissues
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7dc3ee3bfaa04a9794f00cfbcdbd88c3
work_keys_str_mv	AT jeanmarcschwartz probabilisticcontrollabilityapproachtometabolicfluxesinnormalandcancertissues AT hiroakiotokuni probabilisticcontrollabilityapproachtometabolicfluxesinnormalandcancertissues AT tatsuyaakutsu probabilisticcontrollabilityapproachtometabolicfluxesinnormalandcancertissues AT josecnacher probabilisticcontrollabilityapproachtometabolicfluxesinnormalandcancertissues
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Probabilistic controllability approach to metabolic fluxes in normal and cancer tissues

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