Abnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study.

<h4>Background</h4>Internet addiction disorder (IAD) is currently becoming a serious mental health issue around the globe. Previous studies regarding IAD were mainly focused on associated psychological examinations. However, there are few studies on brain structure and function about IAD...

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Autores principales:	Fuchun Lin, Yan Zhou, Yasong Du, Lindi Qin, Zhimin Zhao, Jianrong Xu, Hao Lei
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7dca0a19dd394d9381d5b5e4974de5c7
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spelling	oai:doaj.org-article:7dca0a19dd394d9381d5b5e4974de5c72021-11-18T07:30:24ZAbnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study.1932-620310.1371/journal.pone.0030253https://doaj.org/article/7dca0a19dd394d9381d5b5e4974de5c72012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22253926/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Internet addiction disorder (IAD) is currently becoming a serious mental health issue around the globe. Previous studies regarding IAD were mainly focused on associated psychological examinations. However, there are few studies on brain structure and function about IAD. In this study, we used diffusion tensor imaging (DTI) to investigate white matter integrity in adolescents with IAD.<h4>Methodology/principal findings</h4>Seventeen IAD subjects and sixteen healthy controls without IAD participated in this study. Whole brain voxel-wise analysis of fractional anisotropy (FA) was performed by tract-based spatial statistics (TBSS) to localize abnormal white matter regions between groups. TBSS demonstrated that IAD had significantly lower FA than controls throughout the brain, including the orbito-frontal white matter, corpus callosum, cingulum, inferior fronto-occipital fasciculus, and corona radiation, internal and external capsules, while exhibiting no areas of higher FA. Volume-of-interest (VOI) analysis was used to detect changes of diffusivity indices in the regions showing FA abnormalities. In most VOIs, FA reductions were caused by an increase in radial diffusivity while no changes in axial diffusivity. Correlation analysis was performed to assess the relationship between FA and behavioral measures within the IAD group. Significantly negative correlations were found between FA values in the left genu of the corpus callosum and the Screen for Child Anxiety Related Emotional Disorders, and between FA values in the left external capsule and the Young's Internet addiction scale.<h4>Conclusions</h4>Our findings suggest that IAD demonstrated widespread reductions of FA in major white matter pathways and such abnormal white matter structure may be linked to some behavioral impairments. In addition, white matter integrity may serve as a potential new treatment target and FA may be as a qualified biomarker to understand the underlying neural mechanisms of injury or to assess the effectiveness of specific early interventions in IAD.Fuchun LinYan ZhouYasong DuLindi QinZhimin ZhaoJianrong XuHao LeiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e30253 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fuchun Lin Yan Zhou Yasong Du Lindi Qin Zhimin Zhao Jianrong Xu Hao Lei Abnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study.
description	<h4>Background</h4>Internet addiction disorder (IAD) is currently becoming a serious mental health issue around the globe. Previous studies regarding IAD were mainly focused on associated psychological examinations. However, there are few studies on brain structure and function about IAD. In this study, we used diffusion tensor imaging (DTI) to investigate white matter integrity in adolescents with IAD.<h4>Methodology/principal findings</h4>Seventeen IAD subjects and sixteen healthy controls without IAD participated in this study. Whole brain voxel-wise analysis of fractional anisotropy (FA) was performed by tract-based spatial statistics (TBSS) to localize abnormal white matter regions between groups. TBSS demonstrated that IAD had significantly lower FA than controls throughout the brain, including the orbito-frontal white matter, corpus callosum, cingulum, inferior fronto-occipital fasciculus, and corona radiation, internal and external capsules, while exhibiting no areas of higher FA. Volume-of-interest (VOI) analysis was used to detect changes of diffusivity indices in the regions showing FA abnormalities. In most VOIs, FA reductions were caused by an increase in radial diffusivity while no changes in axial diffusivity. Correlation analysis was performed to assess the relationship between FA and behavioral measures within the IAD group. Significantly negative correlations were found between FA values in the left genu of the corpus callosum and the Screen for Child Anxiety Related Emotional Disorders, and between FA values in the left external capsule and the Young's Internet addiction scale.<h4>Conclusions</h4>Our findings suggest that IAD demonstrated widespread reductions of FA in major white matter pathways and such abnormal white matter structure may be linked to some behavioral impairments. In addition, white matter integrity may serve as a potential new treatment target and FA may be as a qualified biomarker to understand the underlying neural mechanisms of injury or to assess the effectiveness of specific early interventions in IAD.
format	article
author	Fuchun Lin Yan Zhou Yasong Du Lindi Qin Zhimin Zhao Jianrong Xu Hao Lei
author_facet	Fuchun Lin Yan Zhou Yasong Du Lindi Qin Zhimin Zhao Jianrong Xu Hao Lei
author_sort	Fuchun Lin
title	Abnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study.
title_short	Abnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study.
title_full	Abnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study.
title_fullStr	Abnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study.
title_full_unstemmed	Abnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study.
title_sort	abnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/7dca0a19dd394d9381d5b5e4974de5c7
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Abnormal white matter integrity in adolescents with internet addiction disorder: a tract-based spatial statistics study.

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