Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer

Despite the significant advancements made in targeted anti-cancer therapy, drug resistance constitutes a multifaceted phenomenon leading to therapy failure and ultimately mortality. Emerging experimental evidence highlight a role of cholesterol metabolism in facilitating drug resistance in cancer. T...

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Autores principales:	Naaziyah Abdulla, C. Theresa Vincent, Mandeep Kaur
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cholesterol drug resistance hypoxia EMT cancer Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7dccbf38947c499aa607da82a7cd0161
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spelling	oai:doaj.org-article:7dccbf38947c499aa607da82a7cd01612021-11-19T06:05:16ZMechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer2296-634X10.3389/fcell.2021.728325https://doaj.org/article/7dccbf38947c499aa607da82a7cd01612021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.728325/fullhttps://doaj.org/toc/2296-634XDespite the significant advancements made in targeted anti-cancer therapy, drug resistance constitutes a multifaceted phenomenon leading to therapy failure and ultimately mortality. Emerging experimental evidence highlight a role of cholesterol metabolism in facilitating drug resistance in cancer. This review aims to describe the role of cholesterol in facilitating multi-drug resistance in cancer. We focus on specific signaling pathways that contribute to drug resistance and the link between these pathways and cholesterol. Additionally, we briefly discuss the molecular mechanisms related to the epithelial-mesenchymal transition (EMT), and the documented link between EMT, metastasis and drug resistance. We illustrate this by specifically focusing on hypoxia and the role it plays in influencing cellular cholesterol content following EMT induction. Finally, we provide a proposed model delineating the crucial role of cholesterol in EMT and discuss whether targeting cholesterol could serve as a novel means of combatting drug resistance in cancer progression and metastasis.Naaziyah AbdullaC. Theresa VincentC. Theresa VincentMandeep KaurFrontiers Media S.A.articlecholesteroldrug resistancehypoxiaEMTcancerBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cholesterol drug resistance hypoxia EMT cancer Biology (General) QH301-705.5
spellingShingle	cholesterol drug resistance hypoxia EMT cancer Biology (General) QH301-705.5 Naaziyah Abdulla C. Theresa Vincent C. Theresa Vincent Mandeep Kaur Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer
description	Despite the significant advancements made in targeted anti-cancer therapy, drug resistance constitutes a multifaceted phenomenon leading to therapy failure and ultimately mortality. Emerging experimental evidence highlight a role of cholesterol metabolism in facilitating drug resistance in cancer. This review aims to describe the role of cholesterol in facilitating multi-drug resistance in cancer. We focus on specific signaling pathways that contribute to drug resistance and the link between these pathways and cholesterol. Additionally, we briefly discuss the molecular mechanisms related to the epithelial-mesenchymal transition (EMT), and the documented link between EMT, metastasis and drug resistance. We illustrate this by specifically focusing on hypoxia and the role it plays in influencing cellular cholesterol content following EMT induction. Finally, we provide a proposed model delineating the crucial role of cholesterol in EMT and discuss whether targeting cholesterol could serve as a novel means of combatting drug resistance in cancer progression and metastasis.
format	article
author	Naaziyah Abdulla C. Theresa Vincent C. Theresa Vincent Mandeep Kaur
author_facet	Naaziyah Abdulla C. Theresa Vincent C. Theresa Vincent Mandeep Kaur
author_sort	Naaziyah Abdulla
title	Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer
title_short	Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer
title_full	Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer
title_fullStr	Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer
title_full_unstemmed	Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer
title_sort	mechanistic insights delineating the role of cholesterol in epithelial mesenchymal transition and drug resistance in cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7dccbf38947c499aa607da82a7cd0161
work_keys_str_mv	AT naaziyahabdulla mechanisticinsightsdelineatingtheroleofcholesterolinepithelialmesenchymaltransitionanddrugresistanceincancer AT ctheresavincent mechanisticinsightsdelineatingtheroleofcholesterolinepithelialmesenchymaltransitionanddrugresistanceincancer AT ctheresavincent mechanisticinsightsdelineatingtheroleofcholesterolinepithelialmesenchymaltransitionanddrugresistanceincancer AT mandeepkaur mechanisticinsightsdelineatingtheroleofcholesterolinepithelialmesenchymaltransitionanddrugresistanceincancer
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Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer

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