Temporal information processing in short- and long-term memory of patients with schizophrenia.

Cognitive deficits of patients with schizophrenia have been largely recognized as core symptoms of the disorder. One neglected factor that contributes to these deficits is the comprehension of time. In the present study, we assessed temporal information processing and manipulation from short- and lo...

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Autores principales:	Steffen Landgraf, Joerg Steingen, Yvonne Eppert, Ulrich Niedermeyer, Elke van der Meer, Frank Krueger
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7dd070c101044af79cf04aa3d004b0e5
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spelling	oai:doaj.org-article:7dd070c101044af79cf04aa3d004b0e52021-11-18T07:35:29ZTemporal information processing in short- and long-term memory of patients with schizophrenia.1932-620310.1371/journal.pone.0026140https://doaj.org/article/7dd070c101044af79cf04aa3d004b0e52011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22053182/?tool=EBIhttps://doaj.org/toc/1932-6203Cognitive deficits of patients with schizophrenia have been largely recognized as core symptoms of the disorder. One neglected factor that contributes to these deficits is the comprehension of time. In the present study, we assessed temporal information processing and manipulation from short- and long-term memory in 34 patients with chronic schizophrenia and 34 matched healthy controls. On the short-term memory temporal-order reconstruction task, an incidental or intentional learning strategy was deployed. Patients showed worse overall performance than healthy controls. The intentional learning strategy led to dissociable performance improvement in both groups. Whereas healthy controls improved on a performance measure (serial organization), patients improved on an error measure (inappropriate semantic clustering) when using the intentional instead of the incidental learning strategy. On the long-term memory script-generation task, routine and non-routine events of everyday activities (e.g., buying groceries) had to be generated in either chronological or inverted temporal order. Patients were slower than controls at generating events in the chronological routine condition only. They also committed more sequencing and boundary errors in the inverted conditions. The number of irrelevant events was higher in patients in the chronological, non-routine condition. These results suggest that patients with schizophrenia imprecisely access temporal information from short- and long-term memory. In short-term memory, processing of temporal information led to a reduction in errors rather than, as was the case in healthy controls, to an improvement in temporal-order recall. When accessing temporal information from long-term memory, patients were slower and committed more sequencing, boundary, and intrusion errors. Together, these results suggest that time information can be accessed and processed only imprecisely by patients who provide evidence for impaired time comprehension. This could contribute to symptomatic cognitive deficits and strategic inefficiency in schizophrenia.Steffen LandgrafJoerg SteingenYvonne EppertUlrich NiedermeyerElke van der MeerFrank KruegerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 10, p e26140 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Steffen Landgraf Joerg Steingen Yvonne Eppert Ulrich Niedermeyer Elke van der Meer Frank Krueger Temporal information processing in short- and long-term memory of patients with schizophrenia.
description	Cognitive deficits of patients with schizophrenia have been largely recognized as core symptoms of the disorder. One neglected factor that contributes to these deficits is the comprehension of time. In the present study, we assessed temporal information processing and manipulation from short- and long-term memory in 34 patients with chronic schizophrenia and 34 matched healthy controls. On the short-term memory temporal-order reconstruction task, an incidental or intentional learning strategy was deployed. Patients showed worse overall performance than healthy controls. The intentional learning strategy led to dissociable performance improvement in both groups. Whereas healthy controls improved on a performance measure (serial organization), patients improved on an error measure (inappropriate semantic clustering) when using the intentional instead of the incidental learning strategy. On the long-term memory script-generation task, routine and non-routine events of everyday activities (e.g., buying groceries) had to be generated in either chronological or inverted temporal order. Patients were slower than controls at generating events in the chronological routine condition only. They also committed more sequencing and boundary errors in the inverted conditions. The number of irrelevant events was higher in patients in the chronological, non-routine condition. These results suggest that patients with schizophrenia imprecisely access temporal information from short- and long-term memory. In short-term memory, processing of temporal information led to a reduction in errors rather than, as was the case in healthy controls, to an improvement in temporal-order recall. When accessing temporal information from long-term memory, patients were slower and committed more sequencing, boundary, and intrusion errors. Together, these results suggest that time information can be accessed and processed only imprecisely by patients who provide evidence for impaired time comprehension. This could contribute to symptomatic cognitive deficits and strategic inefficiency in schizophrenia.
format	article
author	Steffen Landgraf Joerg Steingen Yvonne Eppert Ulrich Niedermeyer Elke van der Meer Frank Krueger
author_facet	Steffen Landgraf Joerg Steingen Yvonne Eppert Ulrich Niedermeyer Elke van der Meer Frank Krueger
author_sort	Steffen Landgraf
title	Temporal information processing in short- and long-term memory of patients with schizophrenia.
title_short	Temporal information processing in short- and long-term memory of patients with schizophrenia.
title_full	Temporal information processing in short- and long-term memory of patients with schizophrenia.
title_fullStr	Temporal information processing in short- and long-term memory of patients with schizophrenia.
title_full_unstemmed	Temporal information processing in short- and long-term memory of patients with schizophrenia.
title_sort	temporal information processing in short- and long-term memory of patients with schizophrenia.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/7dd070c101044af79cf04aa3d004b0e5
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Temporal information processing in short- and long-term memory of patients with schizophrenia.

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