The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis

Abstract Several randomized clinical trials (RCTs) have investigated the effect of dietary advanced glycation end products (AGE) on obesity factors and related hormones in adults; results were conflicting. Therefore, a study was performed to assess the effect of low advanced glycation end products d...

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Autores principales: Mohammad Hassan Sohouli, Elham Sharifi-Zahabi, Abolfazl Lari, Somaye Fatahi, Farzad Shidfar
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Publicado: Nature Portfolio 2020
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spelling oai:doaj.org-article:7dd444028de546e99e490ea12350264b2021-12-02T11:57:58ZThe impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis10.1038/s41598-020-79216-y2045-2322https://doaj.org/article/7dd444028de546e99e490ea12350264b2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79216-yhttps://doaj.org/toc/2045-2322Abstract Several randomized clinical trials (RCTs) have investigated the effect of dietary advanced glycation end products (AGE) on obesity factors and related hormones in adults; results were conflicting. Therefore, a study was performed to assess the effect of low advanced glycation end products diet on obesity and related hormones. A comprehensive literature search without any limitation on language was conducted using the following bibliographical databases: Web of Science, Scopus, Ovid MEDLINE, Cochrane, and Embase up to October, 2019. From the eligible trials, 13 articles were selected for the systematic review and meta-analysis. Our systematic reviews and meta-analyses have shown a significant decrease in BMI (WMD: − 0.3 kg/m2; 95% CI: − 0.52, − 0.09, p = 0.005; I2 = 55.8%), weight (WMD: − 0.83 kg; 95% CI: − 1.55, − 0.10, p = 0.026; I2 = 67.0%), and leptin (WMD: − 19.85 ng/ml; 95% CI: − 29.88, − 9.82, p < 0.001; I2 = 81.8%) and an increase in adiponectin (WMD: 5.50 µg/ml; 95% CI: 1.33, 9.67, p = 0.010; I2 = 90.6%) levels after consumption of the low AGE diets compared to the high AGE diets. Also, the effect of intake of low AGE compared to high AGE diets was more pronounced in subgroup with duration > 8 weeks for the BMI and weight. Overall, according to our results, although low AGE diets appeared to be statistically significant in reducing the prevalence of obesity and chronic diseases compared to high consumption of dietary AGEs. But, no clinical significance was observed. Therefore, to confirm these results clinically, further prospective studies should be conducted in this regard. The study protocol was registered in the in International prospective register of systematic reviews (PROSPERO) database as CRD42020203734.Mohammad Hassan SohouliElham Sharifi-ZahabiAbolfazl LariSomaye FatahiFarzad ShidfarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Mohammad Hassan Sohouli
Elham Sharifi-Zahabi
Abolfazl Lari
Somaye Fatahi
Farzad Shidfar
The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis
description Abstract Several randomized clinical trials (RCTs) have investigated the effect of dietary advanced glycation end products (AGE) on obesity factors and related hormones in adults; results were conflicting. Therefore, a study was performed to assess the effect of low advanced glycation end products diet on obesity and related hormones. A comprehensive literature search without any limitation on language was conducted using the following bibliographical databases: Web of Science, Scopus, Ovid MEDLINE, Cochrane, and Embase up to October, 2019. From the eligible trials, 13 articles were selected for the systematic review and meta-analysis. Our systematic reviews and meta-analyses have shown a significant decrease in BMI (WMD: − 0.3 kg/m2; 95% CI: − 0.52, − 0.09, p = 0.005; I2 = 55.8%), weight (WMD: − 0.83 kg; 95% CI: − 1.55, − 0.10, p = 0.026; I2 = 67.0%), and leptin (WMD: − 19.85 ng/ml; 95% CI: − 29.88, − 9.82, p < 0.001; I2 = 81.8%) and an increase in adiponectin (WMD: 5.50 µg/ml; 95% CI: 1.33, 9.67, p = 0.010; I2 = 90.6%) levels after consumption of the low AGE diets compared to the high AGE diets. Also, the effect of intake of low AGE compared to high AGE diets was more pronounced in subgroup with duration > 8 weeks for the BMI and weight. Overall, according to our results, although low AGE diets appeared to be statistically significant in reducing the prevalence of obesity and chronic diseases compared to high consumption of dietary AGEs. But, no clinical significance was observed. Therefore, to confirm these results clinically, further prospective studies should be conducted in this regard. The study protocol was registered in the in International prospective register of systematic reviews (PROSPERO) database as CRD42020203734.
format article
author Mohammad Hassan Sohouli
Elham Sharifi-Zahabi
Abolfazl Lari
Somaye Fatahi
Farzad Shidfar
author_facet Mohammad Hassan Sohouli
Elham Sharifi-Zahabi
Abolfazl Lari
Somaye Fatahi
Farzad Shidfar
author_sort Mohammad Hassan Sohouli
title The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis
title_short The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis
title_full The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis
title_fullStr The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis
title_full_unstemmed The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis
title_sort impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/7dd444028de546e99e490ea12350264b
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