Safety study of malapposition of the bio-corrodible nitrided iron stent in vivo

To evaluate the safety of stent malapposition of corrodible nitride iron stent as biodegradable cardiovascular implants, a total of 108 stents were implanted into the abdominal aortas, iliac arteries, and iliac artery bifurcations of 36 New Zealand white rabbits separately. Each rabbit was implanted...

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Autores principales: Shi Xiaoli, Wang Jin, Zhang Gui, Zhang Lu, Zhang Wanqian, Cao Ping, Wang Geqi, Zhang Deyuan, Qin Li
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Lenguaje:EN
Publicado: De Gruyter 2021
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Acceso en línea:https://doaj.org/article/7dd49fc16d0248d0a8b4efd0a41000e9
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spelling oai:doaj.org-article:7dd49fc16d0248d0a8b4efd0a41000e92021-12-05T14:10:58ZSafety study of malapposition of the bio-corrodible nitrided iron stent in vivo2191-909710.1515/ntrev-2021-0062https://doaj.org/article/7dd49fc16d0248d0a8b4efd0a41000e92021-08-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0062https://doaj.org/toc/2191-9097To evaluate the safety of stent malapposition of corrodible nitride iron stent as biodegradable cardiovascular implants, a total of 108 stents were implanted into the abdominal aortas, iliac arteries, and iliac artery bifurcations of 36 New Zealand white rabbits separately. Each rabbit was implanted with three stents. After a follow-up period of 3 months, no thrombus and embolism were found in local and downstream vessels. And no other adverse events occurred either. Stent strut covered by endothelial layer started to show signs of degradation, while struts exposed to bifurcated blood flow covered by a layer of tissue and no rust particle was found on the surface. Also, there were no traces of thrombosis and traces of excess inflammation. The authors conclude that the risk brought by stent malapposition in less than 9 months is acceptable.Shi XiaoliWang JinZhang GuiZhang LuZhang WanqianCao PingWang GeqiZhang DeyuanQin LiDe Gruyterarticlebio-absorb iron stentcorrosioniron overloadstent malappositionthrombosisTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 839-846 (2021)
institution DOAJ
collection DOAJ
language EN
topic bio-absorb iron stent
corrosion
iron overload
stent malapposition
thrombosis
Technology
T
Chemical technology
TP1-1185
Physical and theoretical chemistry
QD450-801
spellingShingle bio-absorb iron stent
corrosion
iron overload
stent malapposition
thrombosis
Technology
T
Chemical technology
TP1-1185
Physical and theoretical chemistry
QD450-801
Shi Xiaoli
Wang Jin
Zhang Gui
Zhang Lu
Zhang Wanqian
Cao Ping
Wang Geqi
Zhang Deyuan
Qin Li
Safety study of malapposition of the bio-corrodible nitrided iron stent in vivo
description To evaluate the safety of stent malapposition of corrodible nitride iron stent as biodegradable cardiovascular implants, a total of 108 stents were implanted into the abdominal aortas, iliac arteries, and iliac artery bifurcations of 36 New Zealand white rabbits separately. Each rabbit was implanted with three stents. After a follow-up period of 3 months, no thrombus and embolism were found in local and downstream vessels. And no other adverse events occurred either. Stent strut covered by endothelial layer started to show signs of degradation, while struts exposed to bifurcated blood flow covered by a layer of tissue and no rust particle was found on the surface. Also, there were no traces of thrombosis and traces of excess inflammation. The authors conclude that the risk brought by stent malapposition in less than 9 months is acceptable.
format article
author Shi Xiaoli
Wang Jin
Zhang Gui
Zhang Lu
Zhang Wanqian
Cao Ping
Wang Geqi
Zhang Deyuan
Qin Li
author_facet Shi Xiaoli
Wang Jin
Zhang Gui
Zhang Lu
Zhang Wanqian
Cao Ping
Wang Geqi
Zhang Deyuan
Qin Li
author_sort Shi Xiaoli
title Safety study of malapposition of the bio-corrodible nitrided iron stent in vivo
title_short Safety study of malapposition of the bio-corrodible nitrided iron stent in vivo
title_full Safety study of malapposition of the bio-corrodible nitrided iron stent in vivo
title_fullStr Safety study of malapposition of the bio-corrodible nitrided iron stent in vivo
title_full_unstemmed Safety study of malapposition of the bio-corrodible nitrided iron stent in vivo
title_sort safety study of malapposition of the bio-corrodible nitrided iron stent in vivo
publisher De Gruyter
publishDate 2021
url https://doaj.org/article/7dd49fc16d0248d0a8b4efd0a41000e9
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