Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation

Misalignment between lifestyle and the natural day-night cycle, such as mistimed eating, can negatively impact health. Here the authors show that mistimed feeding alters protein O-GlcNAcylation, a nutrient sensitive post-translational modification.

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Autores principales: Xianhui Liu, Ivana Blaženović, Adam J. Contreras, Thu M. Pham, Christine A. Tabuloc, Ying H. Li, Jian Ji, Oliver Fiehn, Joanna C. Chiu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7dd753e5c95d4a248376025b6e768033
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spelling oai:doaj.org-article:7dd753e5c95d4a248376025b6e7680332021-12-02T15:39:43ZHexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation10.1038/s41467-021-24301-72041-1723https://doaj.org/article/7dd753e5c95d4a248376025b6e7680332021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24301-7https://doaj.org/toc/2041-1723Misalignment between lifestyle and the natural day-night cycle, such as mistimed eating, can negatively impact health. Here the authors show that mistimed feeding alters protein O-GlcNAcylation, a nutrient sensitive post-translational modification.Xianhui LiuIvana BlaženovićAdam J. ContrerasThu M. PhamChristine A. TabulocYing H. LiJian JiOliver FiehnJoanna C. ChiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xianhui Liu
Ivana Blaženović
Adam J. Contreras
Thu M. Pham
Christine A. Tabuloc
Ying H. Li
Jian Ji
Oliver Fiehn
Joanna C. Chiu
Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation
description Misalignment between lifestyle and the natural day-night cycle, such as mistimed eating, can negatively impact health. Here the authors show that mistimed feeding alters protein O-GlcNAcylation, a nutrient sensitive post-translational modification.
format article
author Xianhui Liu
Ivana Blaženović
Adam J. Contreras
Thu M. Pham
Christine A. Tabuloc
Ying H. Li
Jian Ji
Oliver Fiehn
Joanna C. Chiu
author_facet Xianhui Liu
Ivana Blaženović
Adam J. Contreras
Thu M. Pham
Christine A. Tabuloc
Ying H. Li
Jian Ji
Oliver Fiehn
Joanna C. Chiu
author_sort Xianhui Liu
title Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation
title_short Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation
title_full Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation
title_fullStr Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation
title_full_unstemmed Hexosamine biosynthetic pathway and O-GlcNAc-processing enzymes regulate daily rhythms in protein O-GlcNAcylation
title_sort hexosamine biosynthetic pathway and o-glcnac-processing enzymes regulate daily rhythms in protein o-glcnacylation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7dd753e5c95d4a248376025b6e768033
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