Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function
Abstract The overall effect of lifestyle habits, such as alcohol consumption, on general health remains controversial and it is important to clarify how such habits affect aging-related health impairments. To discover novel impacts of lifestyle on general health, we employed a mathematical approach...
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Nature Portfolio
2021
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oai:doaj.org-article:7dd7fe65f14c4962b8e49d6f419ea6922021-12-02T18:49:34ZUnbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function10.1038/s41598-021-95515-42045-2322https://doaj.org/article/7dd7fe65f14c4962b8e49d6f419ea6922021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95515-4https://doaj.org/toc/2045-2322Abstract The overall effect of lifestyle habits, such as alcohol consumption, on general health remains controversial and it is important to clarify how such habits affect aging-related health impairments. To discover novel impacts of lifestyle on general health, we employed a mathematical approach to perform a comprehensive, unbiased, cross-sectional analysis of data from 6036 subjects who participated in a Japanese health checkup. Notably, we found that moderate alcohol consumption was positively correlated with lung function, muscle mass, and strength. Health checkup data were collected periodically from the same subjects. These people were light to moderate drinkers who had high health awareness and were basically free of major underlying diseases. We next analyzed 5 years of data from 1765 of these subjects. We found that higher baseline alcohol consumption, as well as increased alcohol intake over 5 years attenuated time-related deterioration of forced vital capacity without affecting total lung volume. This effect was independent of smoking. Our study suggests a possible protective effect of moderate amounts of alcohol on lung function, due to increased muscle mass/strength and forced vital capacity.Kanako MakinoRyoko Shimizu-HirotaNorio GodaMasahiro HashimotoIchiro KawadaKazuhiro KashiwagiYasushi HirotaHiroshi ItohMasahiro JinzakiYasushi IwaoMinoru KoShigeru KoHiromasa TakaishiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
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Medicine R Science Q Kanako Makino Ryoko Shimizu-Hirota Norio Goda Masahiro Hashimoto Ichiro Kawada Kazuhiro Kashiwagi Yasushi Hirota Hiroshi Itoh Masahiro Jinzaki Yasushi Iwao Minoru Ko Shigeru Ko Hiromasa Takaishi Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function |
| description |
Abstract The overall effect of lifestyle habits, such as alcohol consumption, on general health remains controversial and it is important to clarify how such habits affect aging-related health impairments. To discover novel impacts of lifestyle on general health, we employed a mathematical approach to perform a comprehensive, unbiased, cross-sectional analysis of data from 6036 subjects who participated in a Japanese health checkup. Notably, we found that moderate alcohol consumption was positively correlated with lung function, muscle mass, and strength. Health checkup data were collected periodically from the same subjects. These people were light to moderate drinkers who had high health awareness and were basically free of major underlying diseases. We next analyzed 5 years of data from 1765 of these subjects. We found that higher baseline alcohol consumption, as well as increased alcohol intake over 5 years attenuated time-related deterioration of forced vital capacity without affecting total lung volume. This effect was independent of smoking. Our study suggests a possible protective effect of moderate amounts of alcohol on lung function, due to increased muscle mass/strength and forced vital capacity. |
| format |
article |
| author |
Kanako Makino Ryoko Shimizu-Hirota Norio Goda Masahiro Hashimoto Ichiro Kawada Kazuhiro Kashiwagi Yasushi Hirota Hiroshi Itoh Masahiro Jinzaki Yasushi Iwao Minoru Ko Shigeru Ko Hiromasa Takaishi |
| author_facet |
Kanako Makino Ryoko Shimizu-Hirota Norio Goda Masahiro Hashimoto Ichiro Kawada Kazuhiro Kashiwagi Yasushi Hirota Hiroshi Itoh Masahiro Jinzaki Yasushi Iwao Minoru Ko Shigeru Ko Hiromasa Takaishi |
| author_sort |
Kanako Makino |
| title |
Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function |
| title_short |
Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function |
| title_full |
Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function |
| title_fullStr |
Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function |
| title_full_unstemmed |
Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function |
| title_sort |
unbiased, comprehensive analysis of japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/7dd7fe65f14c4962b8e49d6f419ea692 |
| work_keys_str_mv |
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