Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice

Fashui Hong,1–4 Yingjun Zhou,1–4 Xiaoyang Zhao,5 Lei Sheng,5 Ling Wang6 1Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection, 2Jiangsu Key Laboratory for Food Safety and Nutritional Function, 3Jiangsu Key Laboratory for Eco-Agricul...

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Autores principales:	Hong F, Zhou Y, Zhao X, Sheng L, Wang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Nanosized titanium dioxide Maternal exposure Mice Embryos Skeleton Development Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7dd88ebb99724c01ad2a83272f6c3299
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spelling	oai:doaj.org-article:7dd88ebb99724c01ad2a83272f6c32992021-12-02T03:11:49ZMaternal exposure to nanosized titanium dioxide suppresses embryonic development in mice1178-2013https://doaj.org/article/7dd88ebb99724c01ad2a83272f6c32992017-08-01T00:00:00Zhttps://www.dovepress.com/maternal-exposure-to-nanosized-titanium-dioxide-suppresses-embryonic-d-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Fashui Hong,1–4 Yingjun Zhou,1–4 Xiaoyang Zhao,5 Lei Sheng,5 Ling Wang6 1Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection, 2Jiangsu Key Laboratory for Food Safety and Nutritional Function, 3Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, 4School of Life Sciences, Huaiyin Normal University, Huaian, 5Medical College of Soochow University, Suzhou, 6Library of Soochow University, Suzhou, Jiangsu, China Abstract: Although nanoscale titanium dioxide (nano-TiO2) has been extensively used in industrial food applications and daily products for pregnant women, infants, and children, its potential toxicity on fetal development has been rarely studied. The main objective of this investigation was to establish the effects of maternal exposure of nano-TiO2 on developing embryos. Female imprinting control region mice were orally administered nano-TiO2 from gestational day 0 to 17. Our findings showed that Ti concentrations in maternal serum, placenta, and fetus were increased in nano-TiO2-exposed mice when compared to controls, which resulted in reductions in the contents of calcium and zinc in maternal serum, placenta, and fetus, maternal weight gain, placental weight, fetal weight, number of live fetuses, and fetal crown–rump length as well as cauda length, and caused an increase in the number of both dead fetuses and resorptions. Furthermore, maternal nano-TiO2 exposure inhibited development of the fetal skeleton, suggesting a significant absence of cartilage, reduced or absent ossification, and an increase in the number of fetuses with dysplasia, including exencephaly, spina bifida, coiled tail, scoliosis, rib absence, and sternum absence. These findings indicated that nano-TiO2 can cross the blood–fetal barrier and placental barrier, thereby delaying the development of fetal mice and inducing skeletal malformation. These factors may be associated with reductions in both calcium and zinc in maternal serum and the fetus, and both the placenta and embryos may be major targets of developmental toxicity following maternal exposure to nano-TiO2 during the prenatal period. Therefore, the application of nano-TiO2 should be carried out with caution. Keywords: nanosized titanium dioxide, maternal exposure, embryonic toxicity, skeleton developmental suppressionHong FZhou YZhao XSheng LWang LDove Medical PressarticleNanosized titanium dioxideMaternal exposureMiceEmbryosSkeletonDevelopmentMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6197-6204 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanosized titanium dioxide Maternal exposure Mice Embryos Skeleton Development Medicine (General) R5-920
spellingShingle	Nanosized titanium dioxide Maternal exposure Mice Embryos Skeleton Development Medicine (General) R5-920 Hong F Zhou Y Zhao X Sheng L Wang L Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice
description	Fashui Hong,1–4 Yingjun Zhou,1–4 Xiaoyang Zhao,5 Lei Sheng,5 Ling Wang6 1Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection, 2Jiangsu Key Laboratory for Food Safety and Nutritional Function, 3Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, 4School of Life Sciences, Huaiyin Normal University, Huaian, 5Medical College of Soochow University, Suzhou, 6Library of Soochow University, Suzhou, Jiangsu, China Abstract: Although nanoscale titanium dioxide (nano-TiO2) has been extensively used in industrial food applications and daily products for pregnant women, infants, and children, its potential toxicity on fetal development has been rarely studied. The main objective of this investigation was to establish the effects of maternal exposure of nano-TiO2 on developing embryos. Female imprinting control region mice were orally administered nano-TiO2 from gestational day 0 to 17. Our findings showed that Ti concentrations in maternal serum, placenta, and fetus were increased in nano-TiO2-exposed mice when compared to controls, which resulted in reductions in the contents of calcium and zinc in maternal serum, placenta, and fetus, maternal weight gain, placental weight, fetal weight, number of live fetuses, and fetal crown–rump length as well as cauda length, and caused an increase in the number of both dead fetuses and resorptions. Furthermore, maternal nano-TiO2 exposure inhibited development of the fetal skeleton, suggesting a significant absence of cartilage, reduced or absent ossification, and an increase in the number of fetuses with dysplasia, including exencephaly, spina bifida, coiled tail, scoliosis, rib absence, and sternum absence. These findings indicated that nano-TiO2 can cross the blood–fetal barrier and placental barrier, thereby delaying the development of fetal mice and inducing skeletal malformation. These factors may be associated with reductions in both calcium and zinc in maternal serum and the fetus, and both the placenta and embryos may be major targets of developmental toxicity following maternal exposure to nano-TiO2 during the prenatal period. Therefore, the application of nano-TiO2 should be carried out with caution. Keywords: nanosized titanium dioxide, maternal exposure, embryonic toxicity, skeleton developmental suppression
format	article
author	Hong F Zhou Y Zhao X Sheng L Wang L
author_facet	Hong F Zhou Y Zhao X Sheng L Wang L
author_sort	Hong F
title	Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice
title_short	Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice
title_full	Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice
title_fullStr	Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice
title_full_unstemmed	Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice
title_sort	maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/7dd88ebb99724c01ad2a83272f6c3299
work_keys_str_mv	AT hongf maternalexposuretonanosizedtitaniumdioxidesuppressesembryonicdevelopmentinmice AT zhouy maternalexposuretonanosizedtitaniumdioxidesuppressesembryonicdevelopmentinmice AT zhaox maternalexposuretonanosizedtitaniumdioxidesuppressesembryonicdevelopmentinmice AT shengl maternalexposuretonanosizedtitaniumdioxidesuppressesembryonicdevelopmentinmice AT wangl maternalexposuretonanosizedtitaniumdioxidesuppressesembryonicdevelopmentinmice
_version_	1718401865679372288

Maternal exposure to nanosized titanium dioxide suppresses embryonic development in mice

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