VDAC2 enables BAX to mediate apoptosis and limit tumor development

BAX and BAK are pro-apoptotic proteins whose activity is essential for the action of many anti-cancer drugs and to suppress tumorigenesis. Here, the authors perform a genome-wide CRISPR/Cas9 screen and identify VDAC2 as a promoter of BAX-mediated apoptosis that is important for an efficient chemothe...

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Autores principales:	Hui San Chin, Mark X. Li, Iris K. L. Tan, Robert L. Ninnis, Boris Reljic, Kristen Scicluna, Laura F. Dagley, Jarrod J. Sandow, Gemma L. Kelly, Andre L. Samson, Stephane Chappaz, Seong L. Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M. Hall, Andrew J. Kueh, Michael T. Ryan, Ruth M. Kluck, Philippe Bouillet, Marco J. Herold, Daniel H. D. Gray, David C. S. Huang, Mark F. van Delft, Grant Dewson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7dd8f93e7c6542b48b8f7611205cb9c8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:7dd8f93e7c6542b48b8f7611205cb9c82021-12-02T15:34:46ZVDAC2 enables BAX to mediate apoptosis and limit tumor development10.1038/s41467-018-07309-42041-1723https://doaj.org/article/7dd8f93e7c6542b48b8f7611205cb9c82018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07309-4https://doaj.org/toc/2041-1723BAX and BAK are pro-apoptotic proteins whose activity is essential for the action of many anti-cancer drugs and to suppress tumorigenesis. Here, the authors perform a genome-wide CRISPR/Cas9 screen and identify VDAC2 as a promoter of BAX-mediated apoptosis that is important for an efficient chemotherapeutic response and to suppress tumor formation.Hui San ChinMark X. LiIris K. L. TanRobert L. NinnisBoris ReljicKristen SciclunaLaura F. DagleyJarrod J. SandowGemma L. KellyAndre L. SamsonStephane ChappazSeong L. KhawCatherine ChangAndrew MorokoffKerstin BrinkmannAndrew WebbColin HockingsCathrine M. HallAndrew J. KuehMichael T. RyanRuth M. KluckPhilippe BouilletMarco J. HeroldDaniel H. D. GrayDavid C. S. HuangMark F. van DelftGrant DewsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui San Chin Mark X. Li Iris K. L. Tan Robert L. Ninnis Boris Reljic Kristen Scicluna Laura F. Dagley Jarrod J. Sandow Gemma L. Kelly Andre L. Samson Stephane Chappaz Seong L. Khaw Catherine Chang Andrew Morokoff Kerstin Brinkmann Andrew Webb Colin Hockings Cathrine M. Hall Andrew J. Kueh Michael T. Ryan Ruth M. Kluck Philippe Bouillet Marco J. Herold Daniel H. D. Gray David C. S. Huang Mark F. van Delft Grant Dewson VDAC2 enables BAX to mediate apoptosis and limit tumor development
description	BAX and BAK are pro-apoptotic proteins whose activity is essential for the action of many anti-cancer drugs and to suppress tumorigenesis. Here, the authors perform a genome-wide CRISPR/Cas9 screen and identify VDAC2 as a promoter of BAX-mediated apoptosis that is important for an efficient chemotherapeutic response and to suppress tumor formation.
format	article
author	Hui San Chin Mark X. Li Iris K. L. Tan Robert L. Ninnis Boris Reljic Kristen Scicluna Laura F. Dagley Jarrod J. Sandow Gemma L. Kelly Andre L. Samson Stephane Chappaz Seong L. Khaw Catherine Chang Andrew Morokoff Kerstin Brinkmann Andrew Webb Colin Hockings Cathrine M. Hall Andrew J. Kueh Michael T. Ryan Ruth M. Kluck Philippe Bouillet Marco J. Herold Daniel H. D. Gray David C. S. Huang Mark F. van Delft Grant Dewson
author_facet	Hui San Chin Mark X. Li Iris K. L. Tan Robert L. Ninnis Boris Reljic Kristen Scicluna Laura F. Dagley Jarrod J. Sandow Gemma L. Kelly Andre L. Samson Stephane Chappaz Seong L. Khaw Catherine Chang Andrew Morokoff Kerstin Brinkmann Andrew Webb Colin Hockings Cathrine M. Hall Andrew J. Kueh Michael T. Ryan Ruth M. Kluck Philippe Bouillet Marco J. Herold Daniel H. D. Gray David C. S. Huang Mark F. van Delft Grant Dewson
author_sort	Hui San Chin
title	VDAC2 enables BAX to mediate apoptosis and limit tumor development
title_short	VDAC2 enables BAX to mediate apoptosis and limit tumor development
title_full	VDAC2 enables BAX to mediate apoptosis and limit tumor development
title_fullStr	VDAC2 enables BAX to mediate apoptosis and limit tumor development
title_full_unstemmed	VDAC2 enables BAX to mediate apoptosis and limit tumor development
title_sort	vdac2 enables bax to mediate apoptosis and limit tumor development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7dd8f93e7c6542b48b8f7611205cb9c8
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VDAC2 enables BAX to mediate apoptosis and limit tumor development

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