Optimizing the layer thickness of sol–gel-derived TiO2 coating on polyetheretherketone

Abstract Sol–gel-derived TiO2 coatings have been confirmed to effectively promote bone-bonding behavior on polyetheretherketone (PEEK) surfaces; however, the optimal layer thickness to maximize the osseointegration and adhesive performance has not been yet determined. In this study, we applied sol–g...

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Autores principales:	Makoto Hayashi, Takayoshi Shimizu, Masashi Imamura, Shunsuke Fujibayashi, Seiji Yamaguchi, Koji Goto, Bungo Otsuki, Toshiyuki Kawai, Yaichiro Okuzu, Shuichi Matsuda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7dd8faf56dac449dabba07ed5c7944f9
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spelling	oai:doaj.org-article:7dd8faf56dac449dabba07ed5c7944f92021-12-02T14:53:48ZOptimizing the layer thickness of sol–gel-derived TiO2 coating on polyetheretherketone10.1038/s41598-021-95572-92045-2322https://doaj.org/article/7dd8faf56dac449dabba07ed5c7944f92021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95572-9https://doaj.org/toc/2045-2322Abstract Sol–gel-derived TiO2 coatings have been confirmed to effectively promote bone-bonding behavior on polyetheretherketone (PEEK) surfaces; however, the optimal layer thickness to maximize the osseointegration and adhesive performance has not been yet determined. In this study, we applied sol–gel-derived TiO2 coatings with different layer thicknesses (40 and 120 nm) on PEEK implants to determine the effects of layer thickness on the surface characteristics, adhesive strength, and bone bonding capabilities (including histological osseointegration). The surface analysis results of both coated implants indicated no significant differences concerning the water contact angle, layer adhesion strength, and apatite formation ability in a simulated body fluid. Additionally, the in vivo biomechanical tests revealed a higher bone-bonding strength for both coated PEEK implants (compared with that of the uncoated sample). It was thus concluded that the factor of layer thickness marginally influences the bioactive advantages attained by sol–gel-derived TiO2 coatings on PEEK surfaces, highlighting the significant versatility and clinical availability of this coating technology.Makoto HayashiTakayoshi ShimizuMasashi ImamuraShunsuke FujibayashiSeiji YamaguchiKoji GotoBungo OtsukiToshiyuki KawaiYaichiro OkuzuShuichi MatsudaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Makoto Hayashi Takayoshi Shimizu Masashi Imamura Shunsuke Fujibayashi Seiji Yamaguchi Koji Goto Bungo Otsuki Toshiyuki Kawai Yaichiro Okuzu Shuichi Matsuda Optimizing the layer thickness of sol–gel-derived TiO2 coating on polyetheretherketone
description	Abstract Sol–gel-derived TiO2 coatings have been confirmed to effectively promote bone-bonding behavior on polyetheretherketone (PEEK) surfaces; however, the optimal layer thickness to maximize the osseointegration and adhesive performance has not been yet determined. In this study, we applied sol–gel-derived TiO2 coatings with different layer thicknesses (40 and 120 nm) on PEEK implants to determine the effects of layer thickness on the surface characteristics, adhesive strength, and bone bonding capabilities (including histological osseointegration). The surface analysis results of both coated implants indicated no significant differences concerning the water contact angle, layer adhesion strength, and apatite formation ability in a simulated body fluid. Additionally, the in vivo biomechanical tests revealed a higher bone-bonding strength for both coated PEEK implants (compared with that of the uncoated sample). It was thus concluded that the factor of layer thickness marginally influences the bioactive advantages attained by sol–gel-derived TiO2 coatings on PEEK surfaces, highlighting the significant versatility and clinical availability of this coating technology.
format	article
author	Makoto Hayashi Takayoshi Shimizu Masashi Imamura Shunsuke Fujibayashi Seiji Yamaguchi Koji Goto Bungo Otsuki Toshiyuki Kawai Yaichiro Okuzu Shuichi Matsuda
author_facet	Makoto Hayashi Takayoshi Shimizu Masashi Imamura Shunsuke Fujibayashi Seiji Yamaguchi Koji Goto Bungo Otsuki Toshiyuki Kawai Yaichiro Okuzu Shuichi Matsuda
author_sort	Makoto Hayashi
title	Optimizing the layer thickness of sol–gel-derived TiO2 coating on polyetheretherketone
title_short	Optimizing the layer thickness of sol–gel-derived TiO2 coating on polyetheretherketone
title_full	Optimizing the layer thickness of sol–gel-derived TiO2 coating on polyetheretherketone
title_fullStr	Optimizing the layer thickness of sol–gel-derived TiO2 coating on polyetheretherketone
title_full_unstemmed	Optimizing the layer thickness of sol–gel-derived TiO2 coating on polyetheretherketone
title_sort	optimizing the layer thickness of sol–gel-derived tio2 coating on polyetheretherketone
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7dd8faf56dac449dabba07ed5c7944f9
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Optimizing the layer thickness of sol–gel-derived TiO2 coating on polyetheretherketone

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