Domain insertion permissibility-guided engineering of allostery in ion channels

Allostery is a fundamental principle of protein regulation that remains challenging to engineer. Here authors screen human Inward Rectifier K + Channel Kir2.1 for permissibility to domain insertions and propose that differential permissibility is a metric of latent allosteric capacity in Kir2.1.

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Autores principales:	Willow Coyote-Maestas, Yungui He, Chad L. Myers, Daniel Schmidt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ddc2f2f4a65482e8d4feeb3d72f6b8c
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spelling	oai:doaj.org-article:7ddc2f2f4a65482e8d4feeb3d72f6b8c2021-12-02T15:35:29ZDomain insertion permissibility-guided engineering of allostery in ion channels10.1038/s41467-018-08171-02041-1723https://doaj.org/article/7ddc2f2f4a65482e8d4feeb3d72f6b8c2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08171-0https://doaj.org/toc/2041-1723Allostery is a fundamental principle of protein regulation that remains challenging to engineer. Here authors screen human Inward Rectifier K + Channel Kir2.1 for permissibility to domain insertions and propose that differential permissibility is a metric of latent allosteric capacity in Kir2.1.Willow Coyote-MaestasYungui HeChad L. MyersDaniel SchmidtNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Willow Coyote-Maestas Yungui He Chad L. Myers Daniel Schmidt Domain insertion permissibility-guided engineering of allostery in ion channels
description	Allostery is a fundamental principle of protein regulation that remains challenging to engineer. Here authors screen human Inward Rectifier K + Channel Kir2.1 for permissibility to domain insertions and propose that differential permissibility is a metric of latent allosteric capacity in Kir2.1.
format	article
author	Willow Coyote-Maestas Yungui He Chad L. Myers Daniel Schmidt
author_facet	Willow Coyote-Maestas Yungui He Chad L. Myers Daniel Schmidt
author_sort	Willow Coyote-Maestas
title	Domain insertion permissibility-guided engineering of allostery in ion channels
title_short	Domain insertion permissibility-guided engineering of allostery in ion channels
title_full	Domain insertion permissibility-guided engineering of allostery in ion channels
title_fullStr	Domain insertion permissibility-guided engineering of allostery in ion channels
title_full_unstemmed	Domain insertion permissibility-guided engineering of allostery in ion channels
title_sort	domain insertion permissibility-guided engineering of allostery in ion channels
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7ddc2f2f4a65482e8d4feeb3d72f6b8c
work_keys_str_mv	AT willowcoyotemaestas domaininsertionpermissibilityguidedengineeringofallosteryinionchannels AT yunguihe domaininsertionpermissibilityguidedengineeringofallosteryinionchannels AT chadlmyers domaininsertionpermissibilityguidedengineeringofallosteryinionchannels AT danielschmidt domaininsertionpermissibilityguidedengineeringofallosteryinionchannels
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Domain insertion permissibility-guided engineering of allostery in ion channels

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