Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis

<h4>Background</h4> The objective of this study was to compare the prognostic impact of sarcopenia in patients with head and neck cancer (HNC) treated with surgery or radiation. <h4>Methods</h4> We systematically searched electronic databases to identify articles reporting th...

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Autores principales:	Yukinori Takenaka, Norihiko Takemoto, Ryohei Oya, Hidenori Inohara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7dde7410f5064ff6913d2ba5e942e4a4
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spelling	oai:doaj.org-article:7dde7410f5064ff6913d2ba5e942e4a42021-11-04T07:42:08ZPrognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis1932-6203https://doaj.org/article/7dde7410f5064ff6913d2ba5e942e4a42021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555817/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> The objective of this study was to compare the prognostic impact of sarcopenia in patients with head and neck cancer (HNC) treated with surgery or radiation. <h4>Methods</h4> We systematically searched electronic databases to identify articles reporting the impact of sarcopenia on the prognosis of patients with HNC. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) were extracted and pooled. HR according to treatment modality were estimated using random-effects models. Statistical analyses were carried out using the Comprehensive Meta-Analysis software. <h4>Results</h4> In total, 18 studies enrolling 3,233 patients were included. Sarcopenia was associated with poor OS in both surgery and radiotherapy groups (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.95–3.21; HR 1.63, 95% CI 1.40–1.90, respectively). The HR was significantly higher in the surgery group than in the radiotherapy group (p = 0.004), with similar results obtained for DFS (HR 2.59, 95% CI 1.56–4.31; HR 1.56, 95% CI 1.24–1.97 for the surgery and radiotherapy groups, respectively) and DSS (HR 2.96, 95% CI 0.73–11.95; HR 2.67, 95% CI 1.51–4.73 for the surgery and RT groups, respectively). <h4>Conclusions</h4> Sarcopenia was a poor prognostic factor for HNC, regardless of the treatment modality. However, the adverse effects of sarcopenia on survival were more prominent in the surgery group than in the radiotherapy group. Sarcopenia assessment is required for appropriate treatment decision-making.Yukinori TakenakaNorihiko TakemotoRyohei OyaHidenori InoharaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yukinori Takenaka Norihiko Takemoto Ryohei Oya Hidenori Inohara Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis
description	<h4>Background</h4> The objective of this study was to compare the prognostic impact of sarcopenia in patients with head and neck cancer (HNC) treated with surgery or radiation. <h4>Methods</h4> We systematically searched electronic databases to identify articles reporting the impact of sarcopenia on the prognosis of patients with HNC. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) were extracted and pooled. HR according to treatment modality were estimated using random-effects models. Statistical analyses were carried out using the Comprehensive Meta-Analysis software. <h4>Results</h4> In total, 18 studies enrolling 3,233 patients were included. Sarcopenia was associated with poor OS in both surgery and radiotherapy groups (hazard ratio [HR] 2.50, 95% confidence interval [CI] 1.95–3.21; HR 1.63, 95% CI 1.40–1.90, respectively). The HR was significantly higher in the surgery group than in the radiotherapy group (p = 0.004), with similar results obtained for DFS (HR 2.59, 95% CI 1.56–4.31; HR 1.56, 95% CI 1.24–1.97 for the surgery and radiotherapy groups, respectively) and DSS (HR 2.96, 95% CI 0.73–11.95; HR 2.67, 95% CI 1.51–4.73 for the surgery and RT groups, respectively). <h4>Conclusions</h4> Sarcopenia was a poor prognostic factor for HNC, regardless of the treatment modality. However, the adverse effects of sarcopenia on survival were more prominent in the surgery group than in the radiotherapy group. Sarcopenia assessment is required for appropriate treatment decision-making.
format	article
author	Yukinori Takenaka Norihiko Takemoto Ryohei Oya Hidenori Inohara
author_facet	Yukinori Takenaka Norihiko Takemoto Ryohei Oya Hidenori Inohara
author_sort	Yukinori Takenaka
title	Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis
title_short	Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis
title_full	Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis
title_fullStr	Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis
title_full_unstemmed	Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis
title_sort	prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: a meta-analysis
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7dde7410f5064ff6913d2ba5e942e4a4
work_keys_str_mv	AT yukinoritakenaka prognosticimpactofsarcopeniainpatientswithheadandneckcancertreatedwithsurgeryorradiationametaanalysis AT norihikotakemoto prognosticimpactofsarcopeniainpatientswithheadandneckcancertreatedwithsurgeryorradiationametaanalysis AT ryoheioya prognosticimpactofsarcopeniainpatientswithheadandneckcancertreatedwithsurgeryorradiationametaanalysis AT hidenoriinohara prognosticimpactofsarcopeniainpatientswithheadandneckcancertreatedwithsurgeryorradiationametaanalysis
_version_	1718445031653638144

Prognostic impact of sarcopenia in patients with head and neck cancer treated with surgery or radiation: A meta-analysis

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