Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

The cell adhesion molecule E-selectin regulates haematopoietic stem cell self-renewal in the bone marrow vascular niche. Here, the authors show E-selectin adhesion directly induces survival signaling in acute myeloid leukaemia and therapeutic inhibition improves chemotherapy outcomes in mice.

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Autores principales:	Valerie Barbier, Johanna Erbani, Corrine Fiveash, Julie M. Davies, Joshua Tay, Michael R. Tallack, Jessica Lowe, John L. Magnani, Diwakar R. Pattabiraman, Andrew C. Perkins, Jessica Lisle, John E. J. Rasko, Jean-Pierre Levesque, Ingrid G. Winkler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7dde84bbf79f4a748ecf6d1fab0d7161
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spelling	oai:doaj.org-article:7dde84bbf79f4a748ecf6d1fab0d71612021-12-02T14:40:41ZEndothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance10.1038/s41467-020-15817-52041-1723https://doaj.org/article/7dde84bbf79f4a748ecf6d1fab0d71612020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15817-5https://doaj.org/toc/2041-1723The cell adhesion molecule E-selectin regulates haematopoietic stem cell self-renewal in the bone marrow vascular niche. Here, the authors show E-selectin adhesion directly induces survival signaling in acute myeloid leukaemia and therapeutic inhibition improves chemotherapy outcomes in mice.Valerie BarbierJohanna ErbaniCorrine FiveashJulie M. DaviesJoshua TayMichael R. TallackJessica LoweJohn L. MagnaniDiwakar R. PattabiramanAndrew C. PerkinsJessica LisleJohn E. J. RaskoJean-Pierre LevesqueIngrid G. WinklerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valerie Barbier Johanna Erbani Corrine Fiveash Julie M. Davies Joshua Tay Michael R. Tallack Jessica Lowe John L. Magnani Diwakar R. Pattabiraman Andrew C. Perkins Jessica Lisle John E. J. Rasko Jean-Pierre Levesque Ingrid G. Winkler Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
description	The cell adhesion molecule E-selectin regulates haematopoietic stem cell self-renewal in the bone marrow vascular niche. Here, the authors show E-selectin adhesion directly induces survival signaling in acute myeloid leukaemia and therapeutic inhibition improves chemotherapy outcomes in mice.
format	article
author	Valerie Barbier Johanna Erbani Corrine Fiveash Julie M. Davies Joshua Tay Michael R. Tallack Jessica Lowe John L. Magnani Diwakar R. Pattabiraman Andrew C. Perkins Jessica Lisle John E. J. Rasko Jean-Pierre Levesque Ingrid G. Winkler
author_facet	Valerie Barbier Johanna Erbani Corrine Fiveash Julie M. Davies Joshua Tay Michael R. Tallack Jessica Lowe John L. Magnani Diwakar R. Pattabiraman Andrew C. Perkins Jessica Lisle John E. J. Rasko Jean-Pierre Levesque Ingrid G. Winkler
author_sort	Valerie Barbier
title	Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
title_short	Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
title_full	Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
title_fullStr	Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
title_full_unstemmed	Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
title_sort	endothelial e-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7dde84bbf79f4a748ecf6d1fab0d7161
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Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

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