Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers

Daisy Duan,1 Chenjuan Gu,2 Vsevolod Y Polotsky,2 Jonathan C Jun,2 Luu V Pham2 1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins...

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Autores principales:	Duan D, Gu C, Polotsky VY, Jun JC, Pham LV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	late eating dinner timing sleep architecture eeg spectral power Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/7de89dc8ed824a4eb2224419a1601640
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spelling	oai:doaj.org-article:7de89dc8ed824a4eb2224419a16016402021-12-02T17:15:30ZEffects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers1179-1608https://doaj.org/article/7de89dc8ed824a4eb2224419a16016402021-05-01T00:00:00Zhttps://www.dovepress.com/effects-of-dinner-timing-on-sleep-stage-distribution-and-eeg-power-spe-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Daisy Duan,1 Chenjuan Gu,2 Vsevolod Y Polotsky,2 Jonathan C Jun,2 Luu V Pham2 1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USACorrespondence: Luu V PhamPulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Asthma and Allergy Center, Johns Hopkins Sleep Disorders Center, Baltimore, MD, 21224, USATel +1 410-550-0741Fax +1 410-550-3374Email luu.pham@jhmi.eduPurpose: Eating time and sleep habits are important modifiable behaviors that affect metabolic health, but the relationship between food intake and sleep remains incompletely understood. Observational data suggest that late food intake is associated with impaired sleep quality. We examined the effect of routine dinner (RD, 5 hours before bedtime) vs late dinner (LD, 1 hour before bedtime) on sleep architecture in healthy volunteers.Participants and Methods: This was a post hoc analysis of a randomized crossover study of RD vs LD with a fixed sleep opportunity in a laboratory setting. On each of the two visits, 20 healthy adult volunteers (10 women) received an isocaloric meal followed by overnight polysomnography. Sleep architecture over the course of the night was assessed using visual sleep staging and EEG spectral power analysis and was compared between RD and LD. We modeled the proportions of spectral power in alpha, beta, delta, and theta bands as functions of dinner timing, time of night, and their interaction with mixed-effect spline regression.Results: Conventional sleep stages were similar between the 2 visits. LD caused a 2.5% initial increase in delta power and a reciprocal 2.7% decrease in combined alpha and beta power (p< 0.0001). These effects diminished as sleep continued with a reversal of these patterns in the latter part of the night.Conclusion: Contrary to the existing literature, shifting dinner timing from 5 hours before sleep to 1 hour before sleep in healthy volunteers did not result in significant adverse changes in overnight sleep architecture. In fact, LD was associated with deeper sleep in the beginning of the night and lighter sleep in the latter part of the night in healthy volunteers. This novel manifestation of postprandial hypersomnia may have therapeutic potential in patients with sleep disorders.Keywords: late eating, dinner timing, sleep architecture, EEG spectral powerDuan DGu CPolotsky VYJun JCPham LVDove Medical Pressarticlelate eatingdinner timingsleep architectureeeg spectral powerPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 601-612 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	late eating dinner timing sleep architecture eeg spectral power Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	late eating dinner timing sleep architecture eeg spectral power Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Duan D Gu C Polotsky VY Jun JC Pham LV Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers
description	Daisy Duan,1 Chenjuan Gu,2 Vsevolod Y Polotsky,2 Jonathan C Jun,2 Luu V Pham2 1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USACorrespondence: Luu V PhamPulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Asthma and Allergy Center, Johns Hopkins Sleep Disorders Center, Baltimore, MD, 21224, USATel +1 410-550-0741Fax +1 410-550-3374Email luu.pham@jhmi.eduPurpose: Eating time and sleep habits are important modifiable behaviors that affect metabolic health, but the relationship between food intake and sleep remains incompletely understood. Observational data suggest that late food intake is associated with impaired sleep quality. We examined the effect of routine dinner (RD, 5 hours before bedtime) vs late dinner (LD, 1 hour before bedtime) on sleep architecture in healthy volunteers.Participants and Methods: This was a post hoc analysis of a randomized crossover study of RD vs LD with a fixed sleep opportunity in a laboratory setting. On each of the two visits, 20 healthy adult volunteers (10 women) received an isocaloric meal followed by overnight polysomnography. Sleep architecture over the course of the night was assessed using visual sleep staging and EEG spectral power analysis and was compared between RD and LD. We modeled the proportions of spectral power in alpha, beta, delta, and theta bands as functions of dinner timing, time of night, and their interaction with mixed-effect spline regression.Results: Conventional sleep stages were similar between the 2 visits. LD caused a 2.5% initial increase in delta power and a reciprocal 2.7% decrease in combined alpha and beta power (p< 0.0001). These effects diminished as sleep continued with a reversal of these patterns in the latter part of the night.Conclusion: Contrary to the existing literature, shifting dinner timing from 5 hours before sleep to 1 hour before sleep in healthy volunteers did not result in significant adverse changes in overnight sleep architecture. In fact, LD was associated with deeper sleep in the beginning of the night and lighter sleep in the latter part of the night in healthy volunteers. This novel manifestation of postprandial hypersomnia may have therapeutic potential in patients with sleep disorders.Keywords: late eating, dinner timing, sleep architecture, EEG spectral power
format	article
author	Duan D Gu C Polotsky VY Jun JC Pham LV
author_facet	Duan D Gu C Polotsky VY Jun JC Pham LV
author_sort	Duan D
title	Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers
title_short	Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers
title_full	Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers
title_fullStr	Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers
title_full_unstemmed	Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers
title_sort	effects of dinner timing on sleep stage distribution and eeg power spectrum in healthy volunteers
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7de89dc8ed824a4eb2224419a1601640
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Effects of Dinner Timing on Sleep Stage Distribution and EEG Power Spectrum in Healthy Volunteers

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