Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation

Nose tissue that helps the ear heal Transplanting a sheet of cells from the nose to the middle ear could improve postoperative prognosis for middle ear inflammatory conditions. Kazuhisa Yamamoto of Jikei University School of Medicine and colleagues in Japan developed a novel surgical technique to pr...

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Autores principales:	Kazuhisa Yamamoto, Masayuki Yamato, Tsunetaro Morino, Hiroaki Sugiyama, Ryo Takagi, Yuichiro Yaguchi, Teruo Okano, Hiromi Kojima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/7de982a4e0f64f9fbb1659aa61400144
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spelling	oai:doaj.org-article:7de982a4e0f64f9fbb1659aa614001442021-12-02T13:41:45ZMiddle ear mucosal regeneration by tissue-engineered cell sheet transplantation10.1038/s41536-017-0010-72057-3995https://doaj.org/article/7de982a4e0f64f9fbb1659aa614001442017-03-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0010-7https://doaj.org/toc/2057-3995Nose tissue that helps the ear heal Transplanting a sheet of cells from the nose to the middle ear could improve postoperative prognosis for middle ear inflammatory conditions. Kazuhisa Yamamoto of Jikei University School of Medicine and colleagues in Japan developed a novel surgical technique to prevent postoperative recurrence of chronic middle ear conditions. In adhesive otitis media, the eardrum gets sucked into and stuck in the middle ear space. Cholesteatoma involves abnormal skin growth in the middle ear. Recurrence often follows surgical treatment for these conditions due to delays in regeneration of the middle ear’s mucosal epithelium. The new technique involves transplanting cultured cells from the lining of the nasal cavity to the middle ear during surgery. Five patients treated this way had favorable postoperative outcomes with no adverse effects or complications and satisfactory improvement in hearing levels.Kazuhisa YamamotoMasayuki YamatoTsunetaro MorinoHiroaki SugiyamaRyo TakagiYuichiro YaguchiTeruo OkanoHiromi KojimaNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Kazuhisa Yamamoto Masayuki Yamato Tsunetaro Morino Hiroaki Sugiyama Ryo Takagi Yuichiro Yaguchi Teruo Okano Hiromi Kojima Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation
description	Nose tissue that helps the ear heal Transplanting a sheet of cells from the nose to the middle ear could improve postoperative prognosis for middle ear inflammatory conditions. Kazuhisa Yamamoto of Jikei University School of Medicine and colleagues in Japan developed a novel surgical technique to prevent postoperative recurrence of chronic middle ear conditions. In adhesive otitis media, the eardrum gets sucked into and stuck in the middle ear space. Cholesteatoma involves abnormal skin growth in the middle ear. Recurrence often follows surgical treatment for these conditions due to delays in regeneration of the middle ear’s mucosal epithelium. The new technique involves transplanting cultured cells from the lining of the nasal cavity to the middle ear during surgery. Five patients treated this way had favorable postoperative outcomes with no adverse effects or complications and satisfactory improvement in hearing levels.
format	article
author	Kazuhisa Yamamoto Masayuki Yamato Tsunetaro Morino Hiroaki Sugiyama Ryo Takagi Yuichiro Yaguchi Teruo Okano Hiromi Kojima
author_facet	Kazuhisa Yamamoto Masayuki Yamato Tsunetaro Morino Hiroaki Sugiyama Ryo Takagi Yuichiro Yaguchi Teruo Okano Hiromi Kojima
author_sort	Kazuhisa Yamamoto
title	Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation
title_short	Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation
title_full	Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation
title_fullStr	Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation
title_full_unstemmed	Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation
title_sort	middle ear mucosal regeneration by tissue-engineered cell sheet transplantation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7de982a4e0f64f9fbb1659aa61400144
work_keys_str_mv	AT kazuhisayamamoto middleearmucosalregenerationbytissueengineeredcellsheettransplantation AT masayukiyamato middleearmucosalregenerationbytissueengineeredcellsheettransplantation AT tsunetaromorino middleearmucosalregenerationbytissueengineeredcellsheettransplantation AT hiroakisugiyama middleearmucosalregenerationbytissueengineeredcellsheettransplantation AT ryotakagi middleearmucosalregenerationbytissueengineeredcellsheettransplantation AT yuichiroyaguchi middleearmucosalregenerationbytissueengineeredcellsheettransplantation AT teruookano middleearmucosalregenerationbytissueengineeredcellsheettransplantation AT hiromikojima middleearmucosalregenerationbytissueengineeredcellsheettransplantation
_version_	1718392563304497152

Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation

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