On the association between SARS-COV-2 variants and COVID-19 mortality during the second wave of the pandemic in Europe

Objective This study aims at investigating associations between COVID-19 mortality and SARS-COV-2 variants spread during the second wave of COVID-19 pandemic in Europe. Methods For 38 European countries, data on numbers of COVID-19 deaths, SARS-COV-2 variants spread through time using Nextstrain cla...

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Autores principales:	Katarzyna Jabłońska, Samuel Aballéa, Pascal Auquier, Mondher Toumi
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	covid-19 mortality sars-cov-2 variants variant of concern b.1.1.7 variant Public aspects of medicine RA1-1270 Business HF5001-6182
Acceso en línea:	https://doaj.org/article/7dec878840514d47b5b0c5f4f40b3b88
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spelling	oai:doaj.org-article:7dec878840514d47b5b0c5f4f40b3b882021-11-17T14:21:57ZOn the association between SARS-COV-2 variants and COVID-19 mortality during the second wave of the pandemic in Europe2001-668910.1080/20016689.2021.2002008https://doaj.org/article/7dec878840514d47b5b0c5f4f40b3b882021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/20016689.2021.2002008https://doaj.org/toc/2001-6689Objective This study aims at investigating associations between COVID-19 mortality and SARS-COV-2 variants spread during the second wave of COVID-19 pandemic in Europe. Methods For 38 European countries, data on numbers of COVID-19 deaths, SARS-COV-2 variants spread through time using Nextstrain classification, demographic and health characteristics were collected. Cumulative number of COVID-19 deaths and height of COVID-19 daily deaths peak during the second wave of the pandemic were considered as outcomes. Pearson correlations and multivariate generalized linear models with selection algorithms were used. Results The average proportion of B.1.1.7 variant was found to be a significant predictor of cumulative COVID-19 deaths within two months before the peak and between 1 January–25 February 2021, as well as of the deaths peak height considering proportions during the second wave and the pre-peak period. The average proportion of EU2 variant (S:477 N) was a significant predictor of cumulative COVID-19 deaths in the pre-peak period. Conclusions Our findings suggest that spread of a new variant of concern B.1.1.7 had a significant impact on mortality during the second wave of COVID-19 pandemic in Europe and that proportions of EU2 and B.1.1.7 variants were associated with increased mortality in the initial phase of that wave.Katarzyna JabłońskaSamuel AballéaPascal AuquierMondher ToumiTaylor & Francis Grouparticlecovid-19mortalitysars-cov-2 variantsvariant of concernb.1.1.7 variantPublic aspects of medicineRA1-1270BusinessHF5001-6182ENJournal of Market Access & Health Policy, Vol 9, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 mortality sars-cov-2 variants variant of concern b.1.1.7 variant Public aspects of medicine RA1-1270 Business HF5001-6182
spellingShingle	covid-19 mortality sars-cov-2 variants variant of concern b.1.1.7 variant Public aspects of medicine RA1-1270 Business HF5001-6182 Katarzyna Jabłońska Samuel Aballéa Pascal Auquier Mondher Toumi On the association between SARS-COV-2 variants and COVID-19 mortality during the second wave of the pandemic in Europe
description	Objective This study aims at investigating associations between COVID-19 mortality and SARS-COV-2 variants spread during the second wave of COVID-19 pandemic in Europe. Methods For 38 European countries, data on numbers of COVID-19 deaths, SARS-COV-2 variants spread through time using Nextstrain classification, demographic and health characteristics were collected. Cumulative number of COVID-19 deaths and height of COVID-19 daily deaths peak during the second wave of the pandemic were considered as outcomes. Pearson correlations and multivariate generalized linear models with selection algorithms were used. Results The average proportion of B.1.1.7 variant was found to be a significant predictor of cumulative COVID-19 deaths within two months before the peak and between 1 January–25 February 2021, as well as of the deaths peak height considering proportions during the second wave and the pre-peak period. The average proportion of EU2 variant (S:477 N) was a significant predictor of cumulative COVID-19 deaths in the pre-peak period. Conclusions Our findings suggest that spread of a new variant of concern B.1.1.7 had a significant impact on mortality during the second wave of COVID-19 pandemic in Europe and that proportions of EU2 and B.1.1.7 variants were associated with increased mortality in the initial phase of that wave.
format	article
author	Katarzyna Jabłońska Samuel Aballéa Pascal Auquier Mondher Toumi
author_facet	Katarzyna Jabłońska Samuel Aballéa Pascal Auquier Mondher Toumi
author_sort	Katarzyna Jabłońska
title	On the association between SARS-COV-2 variants and COVID-19 mortality during the second wave of the pandemic in Europe
title_short	On the association between SARS-COV-2 variants and COVID-19 mortality during the second wave of the pandemic in Europe
title_full	On the association between SARS-COV-2 variants and COVID-19 mortality during the second wave of the pandemic in Europe
title_fullStr	On the association between SARS-COV-2 variants and COVID-19 mortality during the second wave of the pandemic in Europe
title_full_unstemmed	On the association between SARS-COV-2 variants and COVID-19 mortality during the second wave of the pandemic in Europe
title_sort	on the association between sars-cov-2 variants and covid-19 mortality during the second wave of the pandemic in europe
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/7dec878840514d47b5b0c5f4f40b3b88
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On the association between SARS-COV-2 variants and COVID-19 mortality during the second wave of the pandemic in Europe

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