Atopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?

Abstract Purpose: To highlight the role of atopobiosis and dysbiosis in the pathomechanism of autoimmune uveitis, therefore supporting fecal microbiota transplant (FMT) and probiotics as potential targeted-treatment for uveitis. Methods: This review synthesized literatures upon the relation between...

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Autores principales:	Triana Hardianti Gunardi, Diannisa Paramita Susantono, Andi Arus Victor, Ratna Sitompul
Formato:	article
Lenguaje:	EN
Publicado:	Knowledge E 2021
Materias:	atopobiosis autoimmune dysbiosis gut–eye axis uveitis Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7df08bdc57ae41f78831a7644d601b65
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spelling	oai:doaj.org-article:7df08bdc57ae41f78831a7644d601b652021-11-09T08:05:35ZAtopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?2008-20102008-322X10.18502/jovr.v16i4.9754https://doaj.org/article/7df08bdc57ae41f78831a7644d601b652021-10-01T00:00:00Zhttps://doi.org/10.18502/jovr.v16i4.9754https://doaj.org/toc/2008-2010https://doaj.org/toc/2008-322XAbstract Purpose: To highlight the role of atopobiosis and dysbiosis in the pathomechanism of autoimmune uveitis, therefore supporting fecal microbiota transplant (FMT) and probiotics as potential targeted-treatment for uveitis. Methods: This review synthesized literatures upon the relation between gut microbiota, autoimmune uveitis, FMT, and probiotics, published from January 2001 to March 2021 and indexed in PubMed, Google Scholar, CrossRef. Results: The basis of the gut–eye axis revolves around occurrences of molecular mimicry, increase in pro-inflammatory cytokines, gut epithelial barrier disruption, and translocation of microbes to distant sites. In patients with autoimmune uveitis, an increase of gut Fusobacterium and Enterobacterium were found. With current knowledge of aforementioned mechanisms, studies modifying the gut microbiome and restoring the physiologic gut barrier has been the main focus for pathomechanism-based therapy. In mice models, FMT and probiotics targeting repopulation of gut microbiota has shown significant improvement in clinical manifestations of uveitis. Consequently, a better understanding in the homeostasis of gut microbiome along with their role in the gut–eye axis is needed to develop practical targeted treatment. Conclusion: Current preliminary studies are promising in establishing a causative gut–eye axis relationship and the possibility of conducting FMT and probiotics as targeted treatment to mitigate autoimmune uveitis, to shorten disease duration, and to prevent further complications.Triana Hardianti GunardiDiannisa Paramita SusantonoAndi Arus VictorRatna SitompulKnowledge Earticleatopobiosisautoimmunedysbiosisgut–eye axisuveitisOphthalmologyRE1-994ENJournal of Ophthalmic & Vision Research, Vol 16, Iss 4, Pp 631-643 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atopobiosis autoimmune dysbiosis gut–eye axis uveitis Ophthalmology RE1-994
spellingShingle	atopobiosis autoimmune dysbiosis gut–eye axis uveitis Ophthalmology RE1-994 Triana Hardianti Gunardi Diannisa Paramita Susantono Andi Arus Victor Ratna Sitompul Atopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?
description	Abstract Purpose: To highlight the role of atopobiosis and dysbiosis in the pathomechanism of autoimmune uveitis, therefore supporting fecal microbiota transplant (FMT) and probiotics as potential targeted-treatment for uveitis. Methods: This review synthesized literatures upon the relation between gut microbiota, autoimmune uveitis, FMT, and probiotics, published from January 2001 to March 2021 and indexed in PubMed, Google Scholar, CrossRef. Results: The basis of the gut–eye axis revolves around occurrences of molecular mimicry, increase in pro-inflammatory cytokines, gut epithelial barrier disruption, and translocation of microbes to distant sites. In patients with autoimmune uveitis, an increase of gut Fusobacterium and Enterobacterium were found. With current knowledge of aforementioned mechanisms, studies modifying the gut microbiome and restoring the physiologic gut barrier has been the main focus for pathomechanism-based therapy. In mice models, FMT and probiotics targeting repopulation of gut microbiota has shown significant improvement in clinical manifestations of uveitis. Consequently, a better understanding in the homeostasis of gut microbiome along with their role in the gut–eye axis is needed to develop practical targeted treatment. Conclusion: Current preliminary studies are promising in establishing a causative gut–eye axis relationship and the possibility of conducting FMT and probiotics as targeted treatment to mitigate autoimmune uveitis, to shorten disease duration, and to prevent further complications.
format	article
author	Triana Hardianti Gunardi Diannisa Paramita Susantono Andi Arus Victor Ratna Sitompul
author_facet	Triana Hardianti Gunardi Diannisa Paramita Susantono Andi Arus Victor Ratna Sitompul
author_sort	Triana Hardianti Gunardi
title	Atopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?
title_short	Atopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?
title_full	Atopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?
title_fullStr	Atopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?
title_full_unstemmed	Atopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?
title_sort	atopobiosis and dysbiosis in ocular diseases: is fecal microbiota transplant and probiotics a promising solution?
publisher	Knowledge E
publishDate	2021
url	https://doaj.org/article/7df08bdc57ae41f78831a7644d601b65
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Atopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?

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