Angiotensin converting enzyme inhibitors and incidence of lung cancer in a population based cohort of common data model in Korea

Abstract Contradictory findings exist about association of angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) with lung cancer development. This was a retrospective observational cohort study that used data from 7 hospitals in Korea, converted to the Observational...

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Autores principales:	Seung-Hwa Lee, Kwang Jin Chun, Jungchan Park, Jinseob Kim, Ji Dong Sung, Rae Woong Park, Jinwook Choi, Kwangmo Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7df111cbe22e4160bba0f8cee6c946ce
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spelling	oai:doaj.org-article:7df111cbe22e4160bba0f8cee6c946ce2021-12-02T17:23:39ZAngiotensin converting enzyme inhibitors and incidence of lung cancer in a population based cohort of common data model in Korea10.1038/s41598-021-97989-82045-2322https://doaj.org/article/7df111cbe22e4160bba0f8cee6c946ce2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97989-8https://doaj.org/toc/2045-2322Abstract Contradictory findings exist about association of angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) with lung cancer development. This was a retrospective observational cohort study that used data from 7 hospitals in Korea, converted to the Observational Medical Outcomes Partnership Common Data Model. The primary outcome was occurrence of lung cancer. A total of 207,794 patients across the 7 databases was included in the final analysis; 33,230 (16%) were prescribed ACEi and 174,564 (84%) were prescribed ARB. Crude analysis adjusted for sex and age showed higher incidence of lung cancer in the ACEi group compared to the ARB group (hazard ratio [HR], 1.46; 95% confidence rate [CI], 1.08–1.97). After propensity-score matching, 30,445 pairs were generated, and there was no difference in incidence of lung cancer between the two groups (HR, 0.93; 95% CI, 0.64–1.35). Patients prescribed ACEi showed no difference in incidence of lung cancer development compared to those using ARB. This finding provides evidence on the association between ACEi and occurrence of lung cancer.Seung-Hwa LeeKwang Jin ChunJungchan ParkJinseob KimJi Dong SungRae Woong ParkJinwook ChoiKwangmo YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seung-Hwa Lee Kwang Jin Chun Jungchan Park Jinseob Kim Ji Dong Sung Rae Woong Park Jinwook Choi Kwangmo Yang Angiotensin converting enzyme inhibitors and incidence of lung cancer in a population based cohort of common data model in Korea
description	Abstract Contradictory findings exist about association of angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) with lung cancer development. This was a retrospective observational cohort study that used data from 7 hospitals in Korea, converted to the Observational Medical Outcomes Partnership Common Data Model. The primary outcome was occurrence of lung cancer. A total of 207,794 patients across the 7 databases was included in the final analysis; 33,230 (16%) were prescribed ACEi and 174,564 (84%) were prescribed ARB. Crude analysis adjusted for sex and age showed higher incidence of lung cancer in the ACEi group compared to the ARB group (hazard ratio [HR], 1.46; 95% confidence rate [CI], 1.08–1.97). After propensity-score matching, 30,445 pairs were generated, and there was no difference in incidence of lung cancer between the two groups (HR, 0.93; 95% CI, 0.64–1.35). Patients prescribed ACEi showed no difference in incidence of lung cancer development compared to those using ARB. This finding provides evidence on the association between ACEi and occurrence of lung cancer.
format	article
author	Seung-Hwa Lee Kwang Jin Chun Jungchan Park Jinseob Kim Ji Dong Sung Rae Woong Park Jinwook Choi Kwangmo Yang
author_facet	Seung-Hwa Lee Kwang Jin Chun Jungchan Park Jinseob Kim Ji Dong Sung Rae Woong Park Jinwook Choi Kwangmo Yang
author_sort	Seung-Hwa Lee
title	Angiotensin converting enzyme inhibitors and incidence of lung cancer in a population based cohort of common data model in Korea
title_short	Angiotensin converting enzyme inhibitors and incidence of lung cancer in a population based cohort of common data model in Korea
title_full	Angiotensin converting enzyme inhibitors and incidence of lung cancer in a population based cohort of common data model in Korea
title_fullStr	Angiotensin converting enzyme inhibitors and incidence of lung cancer in a population based cohort of common data model in Korea
title_full_unstemmed	Angiotensin converting enzyme inhibitors and incidence of lung cancer in a population based cohort of common data model in Korea
title_sort	angiotensin converting enzyme inhibitors and incidence of lung cancer in a population based cohort of common data model in korea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7df111cbe22e4160bba0f8cee6c946ce
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Angiotensin converting enzyme inhibitors and incidence of lung cancer in a population based cohort of common data model in Korea

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