Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR

Abstract Rhodoterpenoids A‒C (1‒3), three new rearranged triterpenoids, together with one new biogenetically related compound, rhodoterpenoid D (4), were isolated and efficiently elucidated from Rhododendron latoucheae by high-performance liquid chromatography−mass spectrometry−solid-phase extractio...

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Autores principales:	Fei Liu, Ya-Nan Wang, Yong Li, Shuang-Gang Ma, Jing Qu, Yun-Bao Liu, Chang-Shan Niu, Zhong-Hai Tang, Tian-Tai Zhang, Yu-Huan Li, Li Li, Shi-Shan Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7df32c212e6448dd9bbec9ffd9ef6021
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spelling	oai:doaj.org-article:7df32c212e6448dd9bbec9ffd9ef60212021-12-02T16:06:14ZRhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR10.1038/s41598-017-06320-x2045-2322https://doaj.org/article/7df32c212e6448dd9bbec9ffd9ef60212017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06320-xhttps://doaj.org/toc/2045-2322Abstract Rhodoterpenoids A‒C (1‒3), three new rearranged triterpenoids, together with one new biogenetically related compound, rhodoterpenoid D (4), were isolated and efficiently elucidated from Rhododendron latoucheae by high-performance liquid chromatography−mass spectrometry−solid-phase extraction−nuclear magnetic resonance (HPLC‒MS‒SPE‒NMR). Compounds 1 and 2 possess an unprecedented skeleton with a 5/7/6/6/6-fused pentacyclic ring system, while compound 3 contains a unique 6/7/6/6/6-fused pentacyclic carbon backbone. Their structures were determined by extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. Plausible biogenetic pathways for 1‒4 were proposed. Compounds 1 and 4 showed potential activity against herpes simplex virus 1 (HSV-1) with IC50 values of 8.62 and 6.87 μM, respectively.Fei LiuYa-Nan WangYong LiShuang-Gang MaJing QuYun-Bao LiuChang-Shan NiuZhong-Hai TangTian-Tai ZhangYu-Huan LiLi LiShi-Shan YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fei Liu Ya-Nan Wang Yong Li Shuang-Gang Ma Jing Qu Yun-Bao Liu Chang-Shan Niu Zhong-Hai Tang Tian-Tai Zhang Yu-Huan Li Li Li Shi-Shan Yu Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR
description	Abstract Rhodoterpenoids A‒C (1‒3), three new rearranged triterpenoids, together with one new biogenetically related compound, rhodoterpenoid D (4), were isolated and efficiently elucidated from Rhododendron latoucheae by high-performance liquid chromatography−mass spectrometry−solid-phase extraction−nuclear magnetic resonance (HPLC‒MS‒SPE‒NMR). Compounds 1 and 2 possess an unprecedented skeleton with a 5/7/6/6/6-fused pentacyclic ring system, while compound 3 contains a unique 6/7/6/6/6-fused pentacyclic carbon backbone. Their structures were determined by extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. Plausible biogenetic pathways for 1‒4 were proposed. Compounds 1 and 4 showed potential activity against herpes simplex virus 1 (HSV-1) with IC50 values of 8.62 and 6.87 μM, respectively.
format	article
author	Fei Liu Ya-Nan Wang Yong Li Shuang-Gang Ma Jing Qu Yun-Bao Liu Chang-Shan Niu Zhong-Hai Tang Tian-Tai Zhang Yu-Huan Li Li Li Shi-Shan Yu
author_facet	Fei Liu Ya-Nan Wang Yong Li Shuang-Gang Ma Jing Qu Yun-Bao Liu Chang-Shan Niu Zhong-Hai Tang Tian-Tai Zhang Yu-Huan Li Li Li Shi-Shan Yu
author_sort	Fei Liu
title	Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR
title_short	Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR
title_full	Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR
title_fullStr	Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR
title_full_unstemmed	Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR
title_sort	rhodoterpenoids a‒c, three new rearranged triterpenoids from rhododendron latoucheae by hplc‒ms‒spe‒nmr
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7df32c212e6448dd9bbec9ffd9ef6021
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Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR

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