Graft-infiltrating host dendritic cells play a key role in organ transplant rejection

Blocking T cell activation in organ transplantation is important to prevent rejection. Here the authors show that unconventional monocyte-derived host dendritic cells enter allogeneic grafts to amplify the T cell response outside lymph nodes.

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Autores principales:	Quan Zhuang, Quan Liu, Sherrie J. Divito, Qiang Zeng, Karim M. Yatim, Andrew D. Hughes, Darling M. Rojas-Canales, A. Nakao, William J. Shufesky, Amanda L. Williams, Rishab Humar, Rosemary A. Hoffman, Warren D. Shlomchik, Martin H. Oberbarnscheidt, Fadi G. Lakkis, Adrian E. Morelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7df4dfdb27c84e1d8072441bd3894303
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:7df4dfdb27c84e1d8072441bd38943032021-12-02T14:40:13ZGraft-infiltrating host dendritic cells play a key role in organ transplant rejection10.1038/ncomms126232041-1723https://doaj.org/article/7df4dfdb27c84e1d8072441bd38943032016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12623https://doaj.org/toc/2041-1723Blocking T cell activation in organ transplantation is important to prevent rejection. Here the authors show that unconventional monocyte-derived host dendritic cells enter allogeneic grafts to amplify the T cell response outside lymph nodes.Quan ZhuangQuan LiuSherrie J. DivitoQiang ZengKarim M. YatimAndrew D. HughesDarling M. Rojas-CanalesA. NakaoWilliam J. ShufeskyAmanda L. WilliamsRishab HumarRosemary A. HoffmanWarren D. ShlomchikMartin H. OberbarnscheidtFadi G. LakkisAdrian E. MorelliNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Quan Zhuang Quan Liu Sherrie J. Divito Qiang Zeng Karim M. Yatim Andrew D. Hughes Darling M. Rojas-Canales A. Nakao William J. Shufesky Amanda L. Williams Rishab Humar Rosemary A. Hoffman Warren D. Shlomchik Martin H. Oberbarnscheidt Fadi G. Lakkis Adrian E. Morelli Graft-infiltrating host dendritic cells play a key role in organ transplant rejection
description	Blocking T cell activation in organ transplantation is important to prevent rejection. Here the authors show that unconventional monocyte-derived host dendritic cells enter allogeneic grafts to amplify the T cell response outside lymph nodes.
format	article
author	Quan Zhuang Quan Liu Sherrie J. Divito Qiang Zeng Karim M. Yatim Andrew D. Hughes Darling M. Rojas-Canales A. Nakao William J. Shufesky Amanda L. Williams Rishab Humar Rosemary A. Hoffman Warren D. Shlomchik Martin H. Oberbarnscheidt Fadi G. Lakkis Adrian E. Morelli
author_facet	Quan Zhuang Quan Liu Sherrie J. Divito Qiang Zeng Karim M. Yatim Andrew D. Hughes Darling M. Rojas-Canales A. Nakao William J. Shufesky Amanda L. Williams Rishab Humar Rosemary A. Hoffman Warren D. Shlomchik Martin H. Oberbarnscheidt Fadi G. Lakkis Adrian E. Morelli
author_sort	Quan Zhuang
title	Graft-infiltrating host dendritic cells play a key role in organ transplant rejection
title_short	Graft-infiltrating host dendritic cells play a key role in organ transplant rejection
title_full	Graft-infiltrating host dendritic cells play a key role in organ transplant rejection
title_fullStr	Graft-infiltrating host dendritic cells play a key role in organ transplant rejection
title_full_unstemmed	Graft-infiltrating host dendritic cells play a key role in organ transplant rejection
title_sort	graft-infiltrating host dendritic cells play a key role in organ transplant rejection
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7df4dfdb27c84e1d8072441bd3894303
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Graft-infiltrating host dendritic cells play a key role in organ transplant rejection

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