The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops

Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line and show that EVI1 overexpression is a result of ‘en...

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Autores principales:	Sophie Ottema, Roger Mulet-Lazaro, Claudia Erpelinck-Verschueren, Stanley van Herk, Marije Havermans, Andrea Arricibita Varea, Michael Vermeulen, H. Berna Beverloo, Stefan Gröschel, Torsten Haferlach, Claudia Haferlach, Bas J. Wouters, Eric Bindels, Leonie Smeenk, Ruud Delwel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7df6196de175464e8b50bb614eba9c97
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spelling	oai:doaj.org-article:7df6196de175464e8b50bb614eba9c972021-12-02T17:37:41ZThe leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops10.1038/s41467-021-25862-32041-1723https://doaj.org/article/7df6196de175464e8b50bb614eba9c972021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25862-3https://doaj.org/toc/2041-1723Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line and show that EVI1 overexpression is a result of ‘enhancer hijacking’ of the MYC superenhancer, which is facilitated by CTCF-mediated loops.Sophie OttemaRoger Mulet-LazaroClaudia Erpelinck-VerschuerenStanley van HerkMarije HavermansAndrea Arricibita VareaMichael VermeulenH. Berna BeverlooStefan GröschelTorsten HaferlachClaudia HaferlachBas J. WoutersEric BindelsLeonie SmeenkRuud DelwelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sophie Ottema Roger Mulet-Lazaro Claudia Erpelinck-Verschueren Stanley van Herk Marije Havermans Andrea Arricibita Varea Michael Vermeulen H. Berna Beverloo Stefan Gröschel Torsten Haferlach Claudia Haferlach Bas J. Wouters Eric Bindels Leonie Smeenk Ruud Delwel The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
description	Chromosome rearrangements can be a cause of altered oncogene expression in cancer, such as a 3q26 translocation in some acute myeloid leukemias (AML) that leads to overexpression of EVI1. Here the authors engineer this rearrangement in a cell line and show that EVI1 overexpression is a result of ‘enhancer hijacking’ of the MYC superenhancer, which is facilitated by CTCF-mediated loops.
format	article
author	Sophie Ottema Roger Mulet-Lazaro Claudia Erpelinck-Verschueren Stanley van Herk Marije Havermans Andrea Arricibita Varea Michael Vermeulen H. Berna Beverloo Stefan Gröschel Torsten Haferlach Claudia Haferlach Bas J. Wouters Eric Bindels Leonie Smeenk Ruud Delwel
author_facet	Sophie Ottema Roger Mulet-Lazaro Claudia Erpelinck-Verschueren Stanley van Herk Marije Havermans Andrea Arricibita Varea Michael Vermeulen H. Berna Beverloo Stefan Gröschel Torsten Haferlach Claudia Haferlach Bas J. Wouters Eric Bindels Leonie Smeenk Ruud Delwel
author_sort	Sophie Ottema
title	The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
title_short	The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
title_full	The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
title_fullStr	The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
title_full_unstemmed	The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
title_sort	leukemic oncogene evi1 hijacks a myc super-enhancer by ctcf-facilitated loops
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7df6196de175464e8b50bb614eba9c97
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The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops

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