Sustainable UV-Crosslinkable Acrylic Pressure-Sensitive Adhesives for Medical Application

This study aimed to investigate the potential of photoreactive acrylate patches as systems for transdermal drug delivery, in particular, using more renewable alternatives and more environmentally friendly synthesis routes of transdermal patches. Therefore, the aim of this study was to develop a tran...

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Autores principales:	Paula Ossowicz-Rupniewska, Paulina Bednarczyk, Małgorzata Nowak, Anna Nowak, Wiktoria Duchnik, Łukasz Kucharski, Joanna Rokicka, Adam Klimowicz, Zbigniew Czech
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acrylic pressure-sensitive adhesives transdermal patch isobornyl methacrylate shear strength adhesion tack Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7dfa3143c6924c808bb5eb836480d216
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id	oai:doaj.org-article:7dfa3143c6924c808bb5eb836480d216
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spelling	oai:doaj.org-article:7dfa3143c6924c808bb5eb836480d2162021-11-11T17:16:17ZSustainable UV-Crosslinkable Acrylic Pressure-Sensitive Adhesives for Medical Application10.3390/ijms2221118401422-00671661-6596https://doaj.org/article/7dfa3143c6924c808bb5eb836480d2162021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11840https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067This study aimed to investigate the potential of photoreactive acrylate patches as systems for transdermal drug delivery, in particular, using more renewable alternatives and more environmentally friendly synthesis routes of transdermal patches. Therefore, the aim of this study was to develop a transdermal patch containing ibuprofen and investigate its performance in vitro through the pigskin. Transparent patches were prepared using four acrylate copolymers with an incorporated photoinitiator. Two types of transdermal patches based on the photocrosslinking acrylic prepolymers with isobornyl methacrylate as biocomponent and monomer increasing Tg (“hard”) were manufactured. The obtained patches were characterized for their adhesive properties and tested for permeability of the active substance. It turns out that patches whose adhesive matrix is photoreactive polyacrylate copolymers have a higher cohesion than patches from commercial adhesives, while the modification of the copolymers with isobornyl methacrylate resulted in an improvement in adhesion and tack. This study demonstrates the feasibility of developing photoreactive acrylic-based transdermal patches that contain biocomponents that can deliver a therapeutically relevant dose of ibuprofen.Paula Ossowicz-RupniewskaPaulina BednarczykMałgorzata NowakAnna NowakWiktoria DuchnikŁukasz KucharskiJoanna RokickaAdam KlimowiczZbigniew CzechMDPI AGarticleacrylic pressure-sensitive adhesivestransdermal patchisobornyl methacrylateshear strengthadhesiontackBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11840, p 11840 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acrylic pressure-sensitive adhesives transdermal patch isobornyl methacrylate shear strength adhesion tack Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	acrylic pressure-sensitive adhesives transdermal patch isobornyl methacrylate shear strength adhesion tack Biology (General) QH301-705.5 Chemistry QD1-999 Paula Ossowicz-Rupniewska Paulina Bednarczyk Małgorzata Nowak Anna Nowak Wiktoria Duchnik Łukasz Kucharski Joanna Rokicka Adam Klimowicz Zbigniew Czech Sustainable UV-Crosslinkable Acrylic Pressure-Sensitive Adhesives for Medical Application
description	This study aimed to investigate the potential of photoreactive acrylate patches as systems for transdermal drug delivery, in particular, using more renewable alternatives and more environmentally friendly synthesis routes of transdermal patches. Therefore, the aim of this study was to develop a transdermal patch containing ibuprofen and investigate its performance in vitro through the pigskin. Transparent patches were prepared using four acrylate copolymers with an incorporated photoinitiator. Two types of transdermal patches based on the photocrosslinking acrylic prepolymers with isobornyl methacrylate as biocomponent and monomer increasing Tg (“hard”) were manufactured. The obtained patches were characterized for their adhesive properties and tested for permeability of the active substance. It turns out that patches whose adhesive matrix is photoreactive polyacrylate copolymers have a higher cohesion than patches from commercial adhesives, while the modification of the copolymers with isobornyl methacrylate resulted in an improvement in adhesion and tack. This study demonstrates the feasibility of developing photoreactive acrylic-based transdermal patches that contain biocomponents that can deliver a therapeutically relevant dose of ibuprofen.
format	article
author	Paula Ossowicz-Rupniewska Paulina Bednarczyk Małgorzata Nowak Anna Nowak Wiktoria Duchnik Łukasz Kucharski Joanna Rokicka Adam Klimowicz Zbigniew Czech
author_facet	Paula Ossowicz-Rupniewska Paulina Bednarczyk Małgorzata Nowak Anna Nowak Wiktoria Duchnik Łukasz Kucharski Joanna Rokicka Adam Klimowicz Zbigniew Czech
author_sort	Paula Ossowicz-Rupniewska
title	Sustainable UV-Crosslinkable Acrylic Pressure-Sensitive Adhesives for Medical Application
title_short	Sustainable UV-Crosslinkable Acrylic Pressure-Sensitive Adhesives for Medical Application
title_full	Sustainable UV-Crosslinkable Acrylic Pressure-Sensitive Adhesives for Medical Application
title_fullStr	Sustainable UV-Crosslinkable Acrylic Pressure-Sensitive Adhesives for Medical Application
title_full_unstemmed	Sustainable UV-Crosslinkable Acrylic Pressure-Sensitive Adhesives for Medical Application
title_sort	sustainable uv-crosslinkable acrylic pressure-sensitive adhesives for medical application
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7dfa3143c6924c808bb5eb836480d216
work_keys_str_mv	AT paulaossowiczrupniewska sustainableuvcrosslinkableacrylicpressuresensitiveadhesivesformedicalapplication AT paulinabednarczyk sustainableuvcrosslinkableacrylicpressuresensitiveadhesivesformedicalapplication AT małgorzatanowak sustainableuvcrosslinkableacrylicpressuresensitiveadhesivesformedicalapplication AT annanowak sustainableuvcrosslinkableacrylicpressuresensitiveadhesivesformedicalapplication AT wiktoriaduchnik sustainableuvcrosslinkableacrylicpressuresensitiveadhesivesformedicalapplication AT łukaszkucharski sustainableuvcrosslinkableacrylicpressuresensitiveadhesivesformedicalapplication AT joannarokicka sustainableuvcrosslinkableacrylicpressuresensitiveadhesivesformedicalapplication AT adamklimowicz sustainableuvcrosslinkableacrylicpressuresensitiveadhesivesformedicalapplication AT zbigniewczech sustainableuvcrosslinkableacrylicpressuresensitiveadhesivesformedicalapplication
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Sustainable UV-Crosslinkable Acrylic Pressure-Sensitive Adhesives for Medical Application

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