Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese
Adolescent idiopathic scoliosis (AIS) is a common pediatric disease leading to spinal deformities. Here, the authors report GWAS followed by genome-wide meta-analysis in up to 79,211 Japanese individuals, identifying 20 genetic loci for AIS, 14 of which were previously unreported, and perform in vit...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7dfc79556b164deb95efe7d5b662ddc2 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7dfc79556b164deb95efe7d5b662ddc2 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7dfc79556b164deb95efe7d5b662ddc22021-12-02T16:50:59ZGenome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese10.1038/s41467-019-11596-w2041-1723https://doaj.org/article/7dfc79556b164deb95efe7d5b662ddc22019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11596-whttps://doaj.org/toc/2041-1723Adolescent idiopathic scoliosis (AIS) is a common pediatric disease leading to spinal deformities. Here, the authors report GWAS followed by genome-wide meta-analysis in up to 79,211 Japanese individuals, identifying 20 genetic loci for AIS, 14 of which were previously unreported, and perform in vitro validation for rs1978060.Ikuyo KouNao OtomoKazuki TakedaYukihide MomozawaHsing-Fang LuMichiaki KuboYoichiro KamataniYoji OguraYohei TakahashiMasahiro NakajimaShohei MinamiKoki UnoNoriaki KawakamiManabu ItoIkuho YonezawaKei WatanabeTakashi KaitoHaruhisa YanagidaHiroshi TaneichiKatsumi HarimayaYuki TaniguchiHideki ShigematsuTakahiro IidaSatoru DemuraRyo SugawaraNobuyuki FujitaMitsuru YagiEijiro OkadaNaobumi HosoganeKatsuki KonoMasaya NakamuraKazuhiro ChibaToshiaki KotaniTsuyoshi SakumaTsutomu AkazawaTeppei SuzukiKotaro NishidaKenichiro KakutaniTaichi TsujiHideki SudoAkira IwataTatsuya SatoSatoshi InamiMorio MatsumotoChikashi TeraoKota WatanabeShiro IkegawaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ikuyo Kou Nao Otomo Kazuki Takeda Yukihide Momozawa Hsing-Fang Lu Michiaki Kubo Yoichiro Kamatani Yoji Ogura Yohei Takahashi Masahiro Nakajima Shohei Minami Koki Uno Noriaki Kawakami Manabu Ito Ikuho Yonezawa Kei Watanabe Takashi Kaito Haruhisa Yanagida Hiroshi Taneichi Katsumi Harimaya Yuki Taniguchi Hideki Shigematsu Takahiro Iida Satoru Demura Ryo Sugawara Nobuyuki Fujita Mitsuru Yagi Eijiro Okada Naobumi Hosogane Katsuki Kono Masaya Nakamura Kazuhiro Chiba Toshiaki Kotani Tsuyoshi Sakuma Tsutomu Akazawa Teppei Suzuki Kotaro Nishida Kenichiro Kakutani Taichi Tsuji Hideki Sudo Akira Iwata Tatsuya Sato Satoshi Inami Morio Matsumoto Chikashi Terao Kota Watanabe Shiro Ikegawa Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese |
| description |
Adolescent idiopathic scoliosis (AIS) is a common pediatric disease leading to spinal deformities. Here, the authors report GWAS followed by genome-wide meta-analysis in up to 79,211 Japanese individuals, identifying 20 genetic loci for AIS, 14 of which were previously unreported, and perform in vitro validation for rs1978060. |
| format |
article |
| author |
Ikuyo Kou Nao Otomo Kazuki Takeda Yukihide Momozawa Hsing-Fang Lu Michiaki Kubo Yoichiro Kamatani Yoji Ogura Yohei Takahashi Masahiro Nakajima Shohei Minami Koki Uno Noriaki Kawakami Manabu Ito Ikuho Yonezawa Kei Watanabe Takashi Kaito Haruhisa Yanagida Hiroshi Taneichi Katsumi Harimaya Yuki Taniguchi Hideki Shigematsu Takahiro Iida Satoru Demura Ryo Sugawara Nobuyuki Fujita Mitsuru Yagi Eijiro Okada Naobumi Hosogane Katsuki Kono Masaya Nakamura Kazuhiro Chiba Toshiaki Kotani Tsuyoshi Sakuma Tsutomu Akazawa Teppei Suzuki Kotaro Nishida Kenichiro Kakutani Taichi Tsuji Hideki Sudo Akira Iwata Tatsuya Sato Satoshi Inami Morio Matsumoto Chikashi Terao Kota Watanabe Shiro Ikegawa |
| author_facet |
Ikuyo Kou Nao Otomo Kazuki Takeda Yukihide Momozawa Hsing-Fang Lu Michiaki Kubo Yoichiro Kamatani Yoji Ogura Yohei Takahashi Masahiro Nakajima Shohei Minami Koki Uno Noriaki Kawakami Manabu Ito Ikuho Yonezawa Kei Watanabe Takashi Kaito Haruhisa Yanagida Hiroshi Taneichi Katsumi Harimaya Yuki Taniguchi Hideki Shigematsu Takahiro Iida Satoru Demura Ryo Sugawara Nobuyuki Fujita Mitsuru Yagi Eijiro Okada Naobumi Hosogane Katsuki Kono Masaya Nakamura Kazuhiro Chiba Toshiaki Kotani Tsuyoshi Sakuma Tsutomu Akazawa Teppei Suzuki Kotaro Nishida Kenichiro Kakutani Taichi Tsuji Hideki Sudo Akira Iwata Tatsuya Sato Satoshi Inami Morio Matsumoto Chikashi Terao Kota Watanabe Shiro Ikegawa |
| author_sort |
Ikuyo Kou |
| title |
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese |
| title_short |
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese |
| title_full |
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese |
| title_fullStr |
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese |
| title_full_unstemmed |
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese |
| title_sort |
genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in japanese |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/7dfc79556b164deb95efe7d5b662ddc2 |
| work_keys_str_mv |
AT ikuyokou genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT naootomo genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT kazukitakeda genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT yukihidemomozawa genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT hsingfanglu genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT michiakikubo genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT yoichirokamatani genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT yojiogura genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT yoheitakahashi genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT masahironakajima genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT shoheiminami genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT kokiuno genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT noriakikawakami genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT manabuito genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT ikuhoyonezawa genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT keiwatanabe genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT takashikaito genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT haruhisayanagida genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT hiroshitaneichi genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT katsumiharimaya genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT yukitaniguchi genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT hidekishigematsu genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT takahiroiida genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT satorudemura genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT ryosugawara genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT nobuyukifujita genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT mitsuruyagi genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT eijirookada genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT naobumihosogane genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT katsukikono genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT masayanakamura genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT kazuhirochiba genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT toshiakikotani genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT tsuyoshisakuma genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT tsutomuakazawa genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT teppeisuzuki genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT kotaronishida genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT kenichirokakutani genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT taichitsuji genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT hidekisudo genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT akiraiwata genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT tatsuyasato genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT satoshiinami genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT moriomatsumoto genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT chikashiterao genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT kotawatanabe genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese AT shiroikegawa genomewideassociationstudyidentifies14previouslyunreportedsusceptibilitylociforadolescentidiopathicscoliosisinjapanese |
| _version_ |
1718382987769282560 |