Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase

Benzo[a]pyrene (BP) is a carcinogen in cigarette smoke that upon metabolic activation reacts with guanine. Here, the authors present the structures of the translesion DNA synthesis polymerase Rev1 in complex with three of the four possible stereoisomeric BP-N 2 -dG adducts, which gives insights how...

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Autores principales:	Olga Rechkoblit, Alexander Kolbanovskiy, Hannah Landes, Nicholas E. Geacintov, Aneel K. Aggarwal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7dfd4600623948c893925d6ff8837886
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spelling	oai:doaj.org-article:7dfd4600623948c893925d6ff88378862021-12-02T15:38:45ZMechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase10.1038/s41467-017-01013-52041-1723https://doaj.org/article/7dfd4600623948c893925d6ff88378862017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01013-5https://doaj.org/toc/2041-1723Benzo[a]pyrene (BP) is a carcinogen in cigarette smoke that upon metabolic activation reacts with guanine. Here, the authors present the structures of the translesion DNA synthesis polymerase Rev1 in complex with three of the four possible stereoisomeric BP-N 2 -dG adducts, which gives insights how Rev1 achieves error-free replication.Olga RechkoblitAlexander KolbanovskiyHannah LandesNicholas E. GeacintovAneel K. AggarwalNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Olga Rechkoblit Alexander Kolbanovskiy Hannah Landes Nicholas E. Geacintov Aneel K. Aggarwal Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase
description	Benzo[a]pyrene (BP) is a carcinogen in cigarette smoke that upon metabolic activation reacts with guanine. Here, the authors present the structures of the translesion DNA synthesis polymerase Rev1 in complex with three of the four possible stereoisomeric BP-N 2 -dG adducts, which gives insights how Rev1 achieves error-free replication.
format	article
author	Olga Rechkoblit Alexander Kolbanovskiy Hannah Landes Nicholas E. Geacintov Aneel K. Aggarwal
author_facet	Olga Rechkoblit Alexander Kolbanovskiy Hannah Landes Nicholas E. Geacintov Aneel K. Aggarwal
author_sort	Olga Rechkoblit
title	Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase
title_short	Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase
title_full	Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase
title_fullStr	Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase
title_full_unstemmed	Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase
title_sort	mechanism of error-free replication across benzo[a]pyrene stereoisomers by rev1 dna polymerase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7dfd4600623948c893925d6ff8837886
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Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase

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