Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis

Cancer metastasis is one of the leading causes of death worldwide, motivating research into identifying new methods of preventing cancer metastasis. Recently there has been increasing interest in understanding how cancer cells transduce mechanical forces into biochemical signals, as metastasis is a...

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Autores principales:	Jenna A. Dombroski, Jacob M. Hope, Nicole S. Sarna, Michael R. King
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Piezo1 mechanotransduction cancer metastasis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7dfd474de95f4b41827ca91ae35936c9
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id	oai:doaj.org-article:7dfd474de95f4b41827ca91ae35936c9
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spelling	oai:doaj.org-article:7dfd474de95f4b41827ca91ae35936c92021-11-25T17:07:28ZChanneling the Force: Piezo1 Mechanotransduction in Cancer Metastasis10.3390/cells101128152073-4409https://doaj.org/article/7dfd474de95f4b41827ca91ae35936c92021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2815https://doaj.org/toc/2073-4409Cancer metastasis is one of the leading causes of death worldwide, motivating research into identifying new methods of preventing cancer metastasis. Recently there has been increasing interest in understanding how cancer cells transduce mechanical forces into biochemical signals, as metastasis is a process that consists of a wide range of physical forces. For instance, the circulatory system through which disseminating cancer cells must transit is an environment characterized by variable fluid shear stress due to blood flow. Cancer cells and other cells can transduce physical stimuli into biochemical responses using the mechanosensitive ion channel Piezo1, which is activated by membrane deformations that occur when cells are exposed to physical forces. When active, Piezo1 opens, allowing for calcium flux into the cell. Calcium, as a ubiquitous second-messenger cation, is associated with many signaling pathways involved in cancer metastasis, such as angiogenesis, cell migration, intravasation, and proliferation. In this review, we discuss the roles of Piezo1 in each stage of cancer metastasis in addition to its roles in immune cell activation and cancer cell death.Jenna A. DombroskiJacob M. HopeNicole S. SarnaMichael R. KingMDPI AGarticlePiezo1mechanotransductioncancer metastasisBiology (General)QH301-705.5ENCells, Vol 10, Iss 2815, p 2815 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Piezo1 mechanotransduction cancer metastasis Biology (General) QH301-705.5
spellingShingle	Piezo1 mechanotransduction cancer metastasis Biology (General) QH301-705.5 Jenna A. Dombroski Jacob M. Hope Nicole S. Sarna Michael R. King Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis
description	Cancer metastasis is one of the leading causes of death worldwide, motivating research into identifying new methods of preventing cancer metastasis. Recently there has been increasing interest in understanding how cancer cells transduce mechanical forces into biochemical signals, as metastasis is a process that consists of a wide range of physical forces. For instance, the circulatory system through which disseminating cancer cells must transit is an environment characterized by variable fluid shear stress due to blood flow. Cancer cells and other cells can transduce physical stimuli into biochemical responses using the mechanosensitive ion channel Piezo1, which is activated by membrane deformations that occur when cells are exposed to physical forces. When active, Piezo1 opens, allowing for calcium flux into the cell. Calcium, as a ubiquitous second-messenger cation, is associated with many signaling pathways involved in cancer metastasis, such as angiogenesis, cell migration, intravasation, and proliferation. In this review, we discuss the roles of Piezo1 in each stage of cancer metastasis in addition to its roles in immune cell activation and cancer cell death.
format	article
author	Jenna A. Dombroski Jacob M. Hope Nicole S. Sarna Michael R. King
author_facet	Jenna A. Dombroski Jacob M. Hope Nicole S. Sarna Michael R. King
author_sort	Jenna A. Dombroski
title	Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis
title_short	Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis
title_full	Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis
title_fullStr	Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis
title_full_unstemmed	Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis
title_sort	channeling the force: piezo1 mechanotransduction in cancer metastasis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7dfd474de95f4b41827ca91ae35936c9
work_keys_str_mv	AT jennaadombroski channelingtheforcepiezo1mechanotransductionincancermetastasis AT jacobmhope channelingtheforcepiezo1mechanotransductionincancermetastasis AT nicolessarna channelingtheforcepiezo1mechanotransductionincancermetastasis AT michaelrking channelingtheforcepiezo1mechanotransductionincancermetastasis
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Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis

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