Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments: A multicenter, double blinded, randomized controlled trial: The C-EASIE trial protocol.

<h4>Background</h4>Sepsis is a potentially life-threatening condition characterized by a deregulated body's response to infection causing injury to its own tissues and organs. Sepsis is the primary cause of death from infection. If not recognized and treated timely, it can evolve wi...

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Autores principales:	Stefanie Vandervelden, Lina Wauters, Jan Breuls, Steffen Fieuws, Philippe Vanhove, Ives Hubloue, Magali Bartiaux, Jacques Creteur, François Stifkens, Koen Monsieurs, Didier Desruelles
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7dfdf31439f545be9eb6e99242659bac
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spelling	oai:doaj.org-article:7dfdf31439f545be9eb6e99242659bac2021-12-02T20:06:01ZEarly administration of Vitamin C in patients with sepsis or septic shock in emergency departments: A multicenter, double blinded, randomized controlled trial: The C-EASIE trial protocol.1932-620310.1371/journal.pone.0259699https://doaj.org/article/7dfdf31439f545be9eb6e99242659bac2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259699https://doaj.org/toc/1932-6203<h4>Background</h4>Sepsis is a potentially life-threatening condition characterized by a deregulated body's response to infection causing injury to its own tissues and organs. Sepsis is the primary cause of death from infection. If not recognized and treated timely, it can evolve within minutes/hours to septic shock. Sepsis is associated with an acute deficiency of Vitamin C. Despite the proof-of-concept of the benefit of administering Vitamin C in patients with sepsis or septic shock, Vitamin C administration is not yet current practice.<h4>Objective</h4>To investigate the potential benefit of early administration of high doses of Vitamin C in addition to standard of care in patients with sepsis or septic shock.<h4>Methods</h4>This phase 3b multi-center trial is conducted in 8 hospitals throughout Belgium. In total 300 patients will be randomly assigned to one of two groups in a 1:1 allocation ratio. The intervention group will receive 1.5 g Vitamin C 4 times a day during 4 days, started within 6 hours after admission. The primary outcome is the average post-baseline patient SOFA score.<h4>Conclusion</h4>This trial will determine whether the early administration of Vitamin C in patients with sepsis or septic shock can lead to a more rapid solution of shock and less deterioration from sepsis to septic shock, hereby reducing morbidity and mortality as well as the length of hospital stay in this patient population.<h4>Trial registration</h4>The C-EASIE trial has been registered on the ClinicalTrials.gov website on 10 February 2021 with registration number NCT04747795.<h4>Trial sponsor</h4>UZ Leuven (sponsor's reference S63213).Stefanie VanderveldenLina WautersJan BreulsSteffen FieuwsPhilippe VanhoveIves HubloueMagali BartiauxJacques CreteurFrançois StifkensKoen MonsieursDidier DesruellesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259699 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefanie Vandervelden Lina Wauters Jan Breuls Steffen Fieuws Philippe Vanhove Ives Hubloue Magali Bartiaux Jacques Creteur François Stifkens Koen Monsieurs Didier Desruelles Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments: A multicenter, double blinded, randomized controlled trial: The C-EASIE trial protocol.
description	<h4>Background</h4>Sepsis is a potentially life-threatening condition characterized by a deregulated body's response to infection causing injury to its own tissues and organs. Sepsis is the primary cause of death from infection. If not recognized and treated timely, it can evolve within minutes/hours to septic shock. Sepsis is associated with an acute deficiency of Vitamin C. Despite the proof-of-concept of the benefit of administering Vitamin C in patients with sepsis or septic shock, Vitamin C administration is not yet current practice.<h4>Objective</h4>To investigate the potential benefit of early administration of high doses of Vitamin C in addition to standard of care in patients with sepsis or septic shock.<h4>Methods</h4>This phase 3b multi-center trial is conducted in 8 hospitals throughout Belgium. In total 300 patients will be randomly assigned to one of two groups in a 1:1 allocation ratio. The intervention group will receive 1.5 g Vitamin C 4 times a day during 4 days, started within 6 hours after admission. The primary outcome is the average post-baseline patient SOFA score.<h4>Conclusion</h4>This trial will determine whether the early administration of Vitamin C in patients with sepsis or septic shock can lead to a more rapid solution of shock and less deterioration from sepsis to septic shock, hereby reducing morbidity and mortality as well as the length of hospital stay in this patient population.<h4>Trial registration</h4>The C-EASIE trial has been registered on the ClinicalTrials.gov website on 10 February 2021 with registration number NCT04747795.<h4>Trial sponsor</h4>UZ Leuven (sponsor's reference S63213).
format	article
author	Stefanie Vandervelden Lina Wauters Jan Breuls Steffen Fieuws Philippe Vanhove Ives Hubloue Magali Bartiaux Jacques Creteur François Stifkens Koen Monsieurs Didier Desruelles
author_facet	Stefanie Vandervelden Lina Wauters Jan Breuls Steffen Fieuws Philippe Vanhove Ives Hubloue Magali Bartiaux Jacques Creteur François Stifkens Koen Monsieurs Didier Desruelles
author_sort	Stefanie Vandervelden
title	Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments: A multicenter, double blinded, randomized controlled trial: The C-EASIE trial protocol.
title_short	Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments: A multicenter, double blinded, randomized controlled trial: The C-EASIE trial protocol.
title_full	Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments: A multicenter, double blinded, randomized controlled trial: The C-EASIE trial protocol.
title_fullStr	Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments: A multicenter, double blinded, randomized controlled trial: The C-EASIE trial protocol.
title_full_unstemmed	Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments: A multicenter, double blinded, randomized controlled trial: The C-EASIE trial protocol.
title_sort	early administration of vitamin c in patients with sepsis or septic shock in emergency departments: a multicenter, double blinded, randomized controlled trial: the c-easie trial protocol.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7dfdf31439f545be9eb6e99242659bac
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Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments: A multicenter, double blinded, randomized controlled trial: The C-EASIE trial protocol.

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