TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration

Supplementation of magnesium (Mg2+) or its inclusion in biomaterials has beneficial effects for bone formation, but it has also been reported that it can have detrimental effects. Here, the authors analyse dose- and time-dependent effects of Mg2+ on bone regeneration and show that it can stimulate m...

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Autores principales:	Wei Qiao, Karen H. M. Wong, Jie Shen, Wenhao Wang, Jun Wu, Jinhua Li, Zhengjie Lin, Zetao Chen, Jukka P. Matinlinna, Yufeng Zheng, Shuilin Wu, Xuanyong Liu, Keng Po Lai, Zhuofan Chen, Yun Wah Lam, Kenneth M. C. Cheung, Kelvin W. K. Yeung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7dfeb7a2d14a47e993bc5ed64b10ab15
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spelling	oai:doaj.org-article:7dfeb7a2d14a47e993bc5ed64b10ab152021-12-02T15:52:52ZTRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration10.1038/s41467-021-23005-22041-1723https://doaj.org/article/7dfeb7a2d14a47e993bc5ed64b10ab152021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23005-2https://doaj.org/toc/2041-1723Supplementation of magnesium (Mg2+) or its inclusion in biomaterials has beneficial effects for bone formation, but it has also been reported that it can have detrimental effects. Here, the authors analyse dose- and time-dependent effects of Mg2+ on bone regeneration and show that it can stimulate monocyte-macrophage lineage cells to support bone formation in the early phases of repair, but inhibit bone repair and mineralization in later stages by promoting a pro-inflammatory environment.Wei QiaoKaren H. M. WongJie ShenWenhao WangJun WuJinhua LiZhengjie LinZetao ChenJukka P. MatinlinnaYufeng ZhengShuilin WuXuanyong LiuKeng Po LaiZhuofan ChenYun Wah LamKenneth M. C. CheungKelvin W. K. YeungNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Qiao Karen H. M. Wong Jie Shen Wenhao Wang Jun Wu Jinhua Li Zhengjie Lin Zetao Chen Jukka P. Matinlinna Yufeng Zheng Shuilin Wu Xuanyong Liu Keng Po Lai Zhuofan Chen Yun Wah Lam Kenneth M. C. Cheung Kelvin W. K. Yeung TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration
description	Supplementation of magnesium (Mg2+) or its inclusion in biomaterials has beneficial effects for bone formation, but it has also been reported that it can have detrimental effects. Here, the authors analyse dose- and time-dependent effects of Mg2+ on bone regeneration and show that it can stimulate monocyte-macrophage lineage cells to support bone formation in the early phases of repair, but inhibit bone repair and mineralization in later stages by promoting a pro-inflammatory environment.
format	article
author	Wei Qiao Karen H. M. Wong Jie Shen Wenhao Wang Jun Wu Jinhua Li Zhengjie Lin Zetao Chen Jukka P. Matinlinna Yufeng Zheng Shuilin Wu Xuanyong Liu Keng Po Lai Zhuofan Chen Yun Wah Lam Kenneth M. C. Cheung Kelvin W. K. Yeung
author_facet	Wei Qiao Karen H. M. Wong Jie Shen Wenhao Wang Jun Wu Jinhua Li Zhengjie Lin Zetao Chen Jukka P. Matinlinna Yufeng Zheng Shuilin Wu Xuanyong Liu Keng Po Lai Zhuofan Chen Yun Wah Lam Kenneth M. C. Cheung Kelvin W. K. Yeung
author_sort	Wei Qiao
title	TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration
title_short	TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration
title_full	TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration
title_fullStr	TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration
title_full_unstemmed	TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration
title_sort	trpm7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7dfeb7a2d14a47e993bc5ed64b10ab15
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TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration

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